PNIPAm hydrogel composite membrane for high-throughput adsorption of biological macromolecules

Xiao, Qianying; Cui, Yan; Meng, Yingshuang; Guo, Fei; Ruan, Xuehua; He, Gaohong; Jiang, Xiaobin

doi:10.1016/j.seppur.2022.121224

Cited by 14 publications

(5 citation statements)

References 51 publications

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“…On the other hand, at a temperature below the LCST, the molecular chains of PDMAEMA aggregated to the water phase, reducing the porosity inside the nanoparticles and slowing down the diffusion of drug molecules. 45 Besides, according to MTT analysis (Fig. S4(a and b) †), the synthesized dual-response PLA-C composite microspheres showed good biocompatibility for potential drug release devices.…”

Section: Sample Mathematical Modelsmentioning

confidence: 92%

Controlled long-term sustained release of poly(lactic acid) composite microspheres with dual-responsive cellulose nanocrystals

Wang¹,

Abdalkarim²,

Gong³

et al. 2023

CrystEngComm

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Section: Sample Mathematical Modelsmentioning

confidence: 92%

Controlled long-term sustained release of poly(lactic acid) composite microspheres with dual-responsive cellulose nanocrystals

Wang¹,

Abdalkarim²,

Gong³

et al. 2023

CrystEngComm

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show abstract

“…; which may cause concern in biomedical application. A few recent investigations were reported on PNIPAM-based copolymeric hydrogel systems, e.g., Laponite ® platelets/PNIPAM hydrogel [162], polypyrrole/PNIPAM hydrogel [163], polyethylene glycol diacrylate (PEGDA)/chitosan (CS)/PNIPAM hydrogel [164], chitosan-N-2-hydroxypropyl trimethylammonium chloride (HACC)/PNIPAM hydrogel [165] etc. ; where biological properties and mechanical properties were improved.…”

Section: Formulation Approaches For Tailoring the Mechanical Behavior...mentioning

confidence: 99%

Modification of Hydrogels and Their Applications in Biomedical Engineering

2023

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Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Preface to "Modification of Hydrogels and Their Applications in Biomedical Engineering"Hydrogels and hydrophilic polymer networks play an important role in biomedical engineering due to their good biocompatibility, biodegradability, hydrophilicity, and mechanical properties, similar to those of some soft tissues. However, single-component hydrogels usually do not meet the basic functional requirements of biomedical engineering, and modification is an effective way to improve the properties of hydrogels. Currently, a variety of multifunctional hydrogels with excellent performance have been developed, which greatly promotes the application of hydrogels in biomedical engineering.This reprint focuses on the modification of hydrogels and their applications in biomedical engineering, aiming to provide a reference for scholars in related fields. It mainly involves the applications of hydrogels in biomedical fields such as phantoms, wound healing, skin, cartilage, muscle, and drug loading. We believe this book can provide a valuable reference for scientific and technological workers in the fields of materials science, tissue engineering, biological manufacturing, biomedical engineering, and so on.We would like to thank all the contributing authors whose expert contributions made the publication of this Special Issue possible. We would also like to express our deepest appreciation to the editorial team, especially Ms. Miranda Song at MDPI, for their encouragement, technical guidance, editing, and publication of this Special Issue. Special thanks go to all reviewers for helping us ensure the quality of each published article.

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“…; which may cause concern in biomedical application. A few recent investigations were reported on PNIPAM-based copolymeric hydrogel systems, e.g., Laponite ® platelets/PNIPAM hydrogel [ 162 ], polypyrrole/PNIPAM hydrogel [ 163 ], polyethylene glycol diacrylate (PEGDA)/chitosan (CS)/PNIPAM hydrogel [ 164 ], chitosan– N -2-hydroxypropyl trimethylammonium chloride (HACC)/PNIPAM hydrogel [ 165 ] etc. ; where biological properties and mechanical properties were improved.…”

Section: Formulation Approaches For Tailoring the Mechanical Behavior...mentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Ansari

Rajendran

Mohanto

et al. 2022

Gels

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A prominent research topic in contemporary advanced functional materials science is the production of smart materials based on polymers that may independently adjust their physical and/or chemical characteristics when subjected to external stimuli. Smart hydrogels based on poly(N-isopropylacrylamide) (PNIPAM) demonstrate distinct thermoresponsive features close to a lower critical solution temperature (LCST) that enhance their capability in various biomedical applications such as drug delivery, tissue engineering, and wound dressings. Nevertheless, they have intrinsic shortcomings such as poor mechanical properties, limited loading capacity of actives, and poor biodegradability. Formulation of PNIPAM with diverse functional constituents to develop hydrogel composites is an efficient scheme to overcome these defects, which can significantly help for practicable application. This review reports on the latest developments in functional PNIPAM-based smart hydrogels for various biomedical applications. The first section describes the properties of PNIPAM-based hydrogels, followed by potential applications in diverse fields. Ultimately, this review summarizes the challenges and opportunities in this emerging area of research and development concerning this fascinating polymer-based system deep-rooted in chemistry and material science.

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PNIPAm hydrogel composite membrane for high-throughput adsorption of biological macromolecules

Cited by 14 publications

References 51 publications

Controlled long-term sustained release of poly(lactic acid) composite microspheres with dual-responsive cellulose nanocrystals

Controlled long-term sustained release of poly(lactic acid) composite microspheres with dual-responsive cellulose nanocrystals

Modification of Hydrogels and Their Applications in Biomedical Engineering

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

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