“…Animal models described to date include several inbred mouse strains, hamsters, civet cats, ferrets, cats, or nonhuman primates (Fouchier et al, 2003; Glass et al, 2004; Greenough et al, 2005; Hogan et al, 2004; Lawler et al, 2006; Martina et al, 2003; McAuliffe et al, 2004; Qin et al, 2005; Roberts et al, 2005a; 2005b; 2007; Rowe et al, 2004a; Subbarao et al, 2004; ter Meulen et al, 2004; Wu et al, 2005). The timecourse of virus replication in these small animal models is significantly more rapid than that observed in human infections (Roberts et al, 2008) and no model fully reproduces the clinical illness or the pathology observed in humans.…”