Pneumonia in the new-born

Macgregor, Agnes R.

doi:10.1136/adc.14.80.323

Cited by 41 publications

(8 citation statements)

References 13 publications

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“…This, combined with the high incidence of abnormal deliveries, which may be associated with intrapartum asphyxia, suggests that anoxia may have played a part in causing pulmonary haemorrhage in the early group. Potter (1952b) and MacGregor (1939) have suggested that anoxia may cause massive pulmonary haemorrhage. MacGregor (1939), in examining 177 cases of neonatal pneumonia, noted 13 cases of pulmonary haemorrhage unaccompanied by inflammation.…”

Section: Resultsmentioning

confidence: 99%

“…Potter (1952b) and MacGregor (1939) have suggested that anoxia may cause massive pulmonary haemorrhage. MacGregor (1939), in examining 177 cases of neonatal pneumonia, noted 13 cases of pulmonary haemorrhage unaccompanied by inflammation. She was of the opinion that asphyxia was the most significant factor in producing congestion and haemorrhage in the lungs.…”

Section: Resultsmentioning

confidence: 99%

“…However, Stowens (1959) states that bacteriological and virological studies on cases of massive pulmonary haemorrhage usually fail to produce an infective agent. MacGregor (1939) believed that haemorrhage occurred first and provided a good medium for bacterial invasion. ARCHIVES OF DISEASE IN CHILDHOOD Two infants had severe heart malformations, undiagnosed in life.…”

Section: Resultsmentioning

confidence: 99%

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Neonatal Death and Massive Pulmonary Haemorrhage in Jamaica

Thorburn¹

1963

Archives of Disease in Childhood

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Massive pulmonary haemorrhage in the newborn is a well-recognized but little understood condition, characterized by the presence in the alveoli and alveolar ducts, and sometimes in the interstitial spaces, of large numbers of erythrocytes. The distribution of haemorrhage may be patchy or confluent causing consolidation, as distinct from the petechial haemorrhages seen in infants dying after premature separation of the placenta, or the septal haemorrhages seen in stillbirths. The condition was probably first described by Browne (1922a) Indies, of which 336 were neonatal deaths and 231 were stillbirths. In this period there were 14,013 births in the obstetric unit and domiciliary service, of which 304 were stillborn and 301 died in the neonatal period. The additional autopsies on newborns were performed on infants from other hospitals in Kingston. The population served by the hospital is multiracial: there is some selection, as the majority of patients come from the poorer classes. The racial constitution of the autopsy population (Bras, Brooks and Watler, 1961) is Negro or mixed-97-2%, White-1-2%, Chinese-08% and East Indian-0 8%.Method of Examination. The autopsy records of all the perinatal deaths were examined and all cases mentioning the presence of pulmonary haemorrhage of any type were scrutinized. The clinical records, gross autopsy findings and microscopic sections were examined. Lung sections were available from all autopsies. Blocks of lung tissue had been fixed in 10% neutral buffered formalin and embedded in paraffin wax. Sections were stained with haematoxylin and eosin.Conditions of Study. Criteria for selection were as follows:1. Death occurred in the first or second week of life; stillbirths were excluded.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Neonatal Death and Massive Pulmonary Haemorrhage in Jamaica

Thorburn¹

1963

Archives of Disease in Childhood

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“…Pneumonia was diagnosed in this study if a baby had the appropriate clinical and radiological findings associated with bacterial pathogens in the upper respiratory tract and the diagnosis led to systemic antibiotic treatment. Pneumonia occurred only in infants with the apathy syndrome and may have been caused by either infection (MacGregor, 1939;Langley and Smith, 1959;Fujikura and Froehlich, 1967) or aspiration of gastric contents (Rhaney and MacGregor, 1948;Barrie, 1968). The mixed acidosis observed in infants with pneumonia could have contributed further to their brain damage.…”

Section: Discussionmentioning

confidence: 99%

Clinical and CSF studies in newborn infants with neurological abnormalities

Souza¹,

Milner²

1974

Archives of Disease in Childhood

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Case reports Case 1.

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confidence: 99%

Two cases illustrating the treatment of neonatal pneumonia

Ratcliff¹

1942

Archives of Disease in Childhood

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A review of the pathological features of pneumonia in the new-born infant was recently published, and in that review Macgregor (1940) proposed a classification which would be equally useful clinically. The cases quoted below serve to illustrate the treatment of Macgregor's first type, namely that associated with aspiration of contents of the amniotic sac.Case reports Case 1. Baby K., a male infant, weighing 6 lb. 2 oz., was delivered after a long labour by an easy low forceps operation in the occipito-anterior position. The mother was a healthy primigravida and no abnormality occurred during pregnancy. At birth the infant was in a state of blue asphyxia, and an unusually large quantity of liquor amnii was drained from the mouth. Respiration became established without difficulty, but the lungs remained water-logged and air entry was restricted to the central and anterior parts of the lungs. Three hours after birth the infant breathed comfortably and there was no cyanosis, but respiration was noisy and there were rales to be heard over the anterior and upper parts of the lungs. At the bases and over the back there was little air entry and a few consonating rales.For the first thirty-six hours of life the condition of the infant gave no cause for alarm. The colour was usually good, though there were attacks of cyanosis soon checked by administration of oxygen. No apparatus of the nature of an oxygen tent was available. During this time the infant was nursed on his right side to allow the left lung to become as free from fluid as possible, and the foot of the cot was raised. After the first eighteen to twenty-four hours no further liquor could be wiped from the mouth, and after twenty-four hours the motions passed contained a large proportion of vernix caseosa.At the age of forty hours dyspnoea and cyanosis were much increased; oxygen was thereafter administered continuously through a nasal catheter. The moist sounds in the lungs were uniformly increased and the area of lung into which the air entered was much reduced. Alarming dyspnoea persisted for the next twelve hours and the distress then slowly diminished.At the age of four days the left lung (lying uppermost) had appreciably greater air entry than before, though it was still very moist. The infant took small feeds of breast milk every two hours on this day, whereas only water had been taken until this time. No alteration of the baby's position was allowed.At five days the infant breathed without effort and the moist sounds in the lungs were further reduced. Air entry into the right lung (lying downwards) became perceptible. On this day it appeared that the baby would probably recover if no infection developed in the still water-logged lungs. For this 153

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Pneumonia in the new-born

Cited by 41 publications

References 13 publications

Neonatal Death and Massive Pulmonary Haemorrhage in Jamaica

Neonatal Death and Massive Pulmonary Haemorrhage in Jamaica

Clinical and CSF studies in newborn infants with neurological abnormalities

Two cases illustrating the treatment of neonatal pneumonia

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