Pneumonia due to <i>Mycoplasma pneumoniae</i> in granulocytopenic children with cancer

Banov, Laura; Garanata, Claudio; Dufour, Carlo; Garaventa, Alberto; Marco, Eddi Di; Caviglia, Ilaria; Moroni, C.; Castagnola, Elio

doi:10.1002/pbc.22075

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Notably, there is no evidence that acquired neutropenia in children with cancer significantly predisposes to M. pneumoniae pneumonia; conversely, recent studies showed a correlation between neutrophil number and extravasation into the lungs with the severity of M. pneumoniae pneumonia in this clinical setting [50,51]. Indeed, Banov et al reported only 3 cases of M. pneumoniae infection in 30 patients developing neutropenia-associated pneumonia in a cohort of 463 children who were treated for malignancy or received a hematopoietic stem cell transplant for a non-neoplastic disease [52].…”

Section: Innate Immunity Defectsmentioning

confidence: 99%

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Mycoplasma pneumoniae Infections and Primary Immune Deficiencies

Poddighe

Demirkaya

Sazonov

et al. 2022

International Journal of Clinical Practice

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Mycoplasma pneumoniae (M. pneumoniae) is one of the leading causes of community-acquired pneumonia in children and is also implicated in a variety of reactive extrapulmonary diseases. Recurrent and/or severe respiratory infections are one of the most frequent manifestations of several types of primary immunodeficiency. Here, we reviewed the medical literature to assess the potential relevance of M. pneumoniae in the infections observed in children affected with combined, humoral, and innate primary immune deficiencies. M. pneumoniae does not result to be epidemiologically prevalent as a cause of pneumonia in children affected by primary immunodeficiencies, but this infection can have a persistent or severe course in this category of patients. Indeed, the active search of M. pneumoniae could be useful and appropriate especially in children with humoral immune deficiencies. Indeed, most cases of M. pneumoniae infection in primary immunodeficiencies are described in patients affected by a/hypo-gammaglobulinemia.

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Section: Innate Immunity Defectsmentioning

confidence: 99%

“…Indeed, Banov et al reported only 3 cases of M . pneumoniae infection in 30 patients developing neutropenia-associated pneumonia in a cohort of 463 children who were treated for malignancy or received a hematopoietic stem cell transplant for a non-neoplastic disease [ 52 ].…”

Section: Innate Immunity Defectsmentioning

confidence: 99%

Mycoplasma pneumoniae Infections and Primary Immune Deficiencies

Poddighe

Demirkaya

Sazonov

et al. 2022

International Journal of Clinical Practice

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“…Mykoplasmenpneumonien krebskranker Kinder und Jugendlicher sind selten und bislang im Wesentlichen kasuistisch be richtet [3]. Gleiches …”

Section: Mykoplasmen Chlamydien Und Legionellenunclassified

Pulmonale Infektionen in der pädiatrischen Hämatologie und Onkologie

Groll

Werner

Tebbe

et al. 2011

Monatsschr Kinderheilkd

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Pneumonia is the most frequent invasive tissue infection in children and adolescents with neoplastic diseases or hematopoietic stem cell transplantation and is associated with considerable mortality. Given the favorable prognosis of most pediatric cancers, the availability of reliable microbiological methods and effective antimicrobial and supportive interventions, a prompt and rational approach to diagnosis and treatment is of pivotal importance. This article reviews the differential diagnosis of invasive infections of the lower airways in this vulnerable patient population and provides algorithms for the diagnosis and management.

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