Pneumonia as a cardiovascular disease

Restrepo, Marcos I.; Reyes, Luis Felipe

doi:10.1111/resp.13233

Cited by 90 publications

(71 citation statements)

References 95 publications

(120 reference statements)

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“…In these studies, the best cut-off values of NT-proBNP for prediction 30-day mortality were 1434.5 pg/mL and 1795.5 pg/ mL, respectively [8,10]. The elevated NT-proBNP in these cases was believed owing to the cardiac complications resulted from complex interactions among preexisting conditions, relative ischemia, up-regulation of the sympathetic system, systemic inflammation and direct pathogenmediated damage to the cardiovascular system [11].…”

Section: Discussionmentioning

confidence: 96%

Prognostic value of NT-proBNP in patients with severe COVID-19

et al. 2020

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Background: The outbreak of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown. Methods: The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records.Results: The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (≤88.64 pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death. Conclusion: NT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19.

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Section: Discussionmentioning

confidence: 96%

Prognostic value of NT-proBNP in patients with severe COVID-19

et al. 2020

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“…In these studies the best cutoffs of NT-proBNP for prediction 30-day mortality were 1,434.5 pg/mL and 1,795.5 pg/mL respectively 7,9 . The elevated NT-proBNP in these cases was believed owing to the cardiac complications resulted from complex interactions among preexisting conditions, relative ischemia, up-regulation of the sympathetic system, systemic inflammation and direct pathogen-mediated damage to the cardiovascular system 10 .…”

Section: Discussionmentioning

confidence: 98%

Prognostic value of NT-proBNP in patients with severe COVID-19

Gao

Jiang

Wen

et al. 2020

Preprint

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The outbreak of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury was dominate in the process. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of COVID-19 patients was unknown. The study initially enrolled 102 patients with severe COVID-19 pneumonia from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. Results found that patients with higher NT-proBNP (above 88.64 pg/mL) level had more risks of inhospital death. After adjusting for potential cofounders in separate modes, NT-proBNP presented as an independent risk factor of in-hospital death in patients with severe COVID-19. : medRxiv preprint Figure 1. The NT-proBNP for in-hospital death of coronavirus disease 2019 (COVID-19) by receiver operating characteristic (ROC) curves. The area under the curve (AUC) of NT-proBNP was 0.909. The best cutoff of NT-proBNP for prediction in-hospital death was 88.64 pg/mL with the sensitivity of 100% and the specificity of 66.67%. 95%CI, 95% confidence interval. All rights reserved. No reuse allowed without permission.the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10. 1101 Figure 2. Kaplan-Meier plots showing the cumulative survival rate of COVID-19 patients who were stratified into two groups according to plasma NT-proBNP cutoff point at baseline (Dotted line, NT-proBNP ≤88.64 pg/ml, n=24; Solid line, NT-proBNP >88.64 pg/ml, n=30; log-rank test for trend, P<0.001).All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

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“…Cardiac thrombosis could be generated locally induced by either exposure to tissue factors following vascular damage，or spontaneously under procoagulant condition secondary to an exaggerated inflammation which stimulated endothelial and mononuclear cells, eventually provoking the coagulation cascade. In addition to clotting activation, systemic coagulation abnormalities also involves suppression of fibrinolysis [8,16,17]. Dehydration ， elderly, obesity, basic diseases ， long-term bedridden, clinical practice of glucocorticoid and immunoglobulin， invasive operation multifactorial， as previously summarized， were the main risk factors of hyperviscosity, which intensified the coagulation disorder.…”

Section: Discussionmentioning

confidence: 99%

Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study

Zhang¹,

Yang

Li³

et al. 2020

Preprint

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Background Since December 2019, a cluster of coronavirus disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China and spread rapidly from China to other countries. In-hospital mortality are high in severe cases and cardiac injury characterized by elevated cardiac troponin are common among them. The mechanism of cardiac injury and the relationship between cardiac injury and in-hospital mortality remained unclear. Studies focused on cardiac injury in COVID-19 patients are scarce.Objectives To investigate the association between cardiac injury and in-hospital mortality of patients with confirmed or suspected COVID-19.Methods Demographic, clinical, treatment, and laboratory data of consecutive confirmed or suspected COVID-19 patients admitted in Wuhan No.1 Hospital from 25 th December, 2019 to 15 th February, 2020 were extracted from electronic medical records and were retrospectively reviewed and analyzed. Univariate and multivariate Cox regression analysis were used to explore the risk factors associated with in-hospital death.Results A total of 110 patients with confirmed (n=80) or suspected (n=30) COVID-19 were screened and 48 patients (female 31.3%, mean age 70.58±13.38 year old) among them with high-sensitivity cardiac troponin I (hs-cTnI) test within 48 hours after admission were included, of whom 17 (17/48, 35.4%) died in hospital while 31 (31/48, 64.6%) were discharged or transferred to other hospital. High-sensitivity cardiac troponin I was elevated in 13 (13/48, 27.1%) patents. Multivariate Cox regression analysis showed pulse oximetry of oxygen saturation (SpO2) on admission (HR 0.704, 95% CI 0.546-0.909, per 1% decrease, p=0.007), elevated hs-cTnI (HR 10.902, 95% 1.279-92.927, p=0.029) and elevated d-dimer (HR 1.103, 95%CI 1.034-1.176, per 1mg/L increase, p=0.003) on admission were independently associated with in-hospital mortality.

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Pneumonia as a cardiovascular disease

Cited by 90 publications

References 95 publications

Prognostic value of NT-proBNP in patients with severe COVID-19

Prognostic value of NT-proBNP in patients with severe COVID-19

Prognostic value of NT-proBNP in patients with severe COVID-19

Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study

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