Pneumonia and bacteraemia caused by <i>Gemella morbillorum</i> in a previously healthy infant: first reported case in literature

Hussain, Sara; Hussain, Sahar; Ashraf, Mohamed

doi:10.1136/bcr-2018-226295

Cited by 6 publications

(5 citation statements)

References 11 publications

(2 reference statements)

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“…G. morbillorum is a facultative anaerobe gram-positive coccus considered to be normal flora of the respiratory, urinary and gastrointestinal tracts in humans 2. Case reports have implicated G. morbillorum as the causative organism of infections throughout the body, most commonly neurological infections and endocarditis 2–6. These tend to occur in immunocompromised hosts.…”

Section: Discussionmentioning

confidence: 99%

“…Gemella morbillorum, formerly known as Streptococcus morbillorum until 1988,1 is part of the normal flora of the respiratory, urinary and gastrointestinal tracts in humans 2. It is an uncommon cause of infection; however, there are case reports in the literature implicating this organism in serious and fatal infections 2–6. Most of these reports are from endocarditis but other organs have also been affected, especially in immunocompromised patients.…”

Section: Introductionmentioning

confidence: 99%

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Gemella morbillorumas a source bacteria for necrotising fasciitis of the torso

et al. 2020

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A 66-year-old man presented with upper back cellulitis and imaging findings consistent with a necrotising soft tissue infection. He was started on broad-spectrum intravenous antibiotics and was taken to the operating room for immediate surgical debridement. On postoperative day 5, the culture was noted to be growing Gemella morbillorum, an exceedingly rare cause of necrotising soft tissue infections in immunocompetent hosts. His condition improved, and he was transitioned to oral antibiotics and discharged home.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gemella morbillorumas a source bacteria for necrotising fasciitis of the torso

et al. 2020

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“…Human infection is rare, although it may be provoked by the use of intravenous drugs, excessive alcohol intake, diabetes mellitus, or poor dentition [ 4 ] [ 5 ]. Pneumonia with sepsis and bacteremia has been reported despite evident clinical symptoms of aspiration in both adults [ 6 ] and children [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Infection and Bacterial Lymphadenitis by Gemella morbillorum Leading to Airway Perforation and a Bronchopleural Fistula

DePrez,

Ferguson

2024

Case Reports in Pulmonology

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Introduction: Necrotizing bronchial infection with severe infectious lymphadenitis is infrequently encountered and most commonly ascribed to Aspergillus, Histoplasma, and Mycobacterium species. We present a unique cause of severe airway destruction with lymphadenitis and bronchopleural fistula formation by the bacterium Gemella morbillorum.Case: A 24‐year‐old man presented with acute symptoms of vomiting, fever, and shoulder pain. A CT of the chest demonstrated a large subcarinal mass encasing the central bronchi. The workup for malignant, fungal, and granulomatous etiologies was unrevealing, while blood cultures identified G. morbillorum. Fiberoptic bronchoscopy revealed a perforation of the right middle lobar bronchus and the formation of a bronchopleural fistula, resulting in a large hydropneumothorax with empyema. Despite antibiotic therapy, surgical intervention to repair the fistula, and ventilatory support, the progression of the bronchopleural fistula led to fatal respiratory failure.Conclusion: In cases of severe mediastinal adenopathy in a young patient, bacterial lymphadenitis should be considered in the differential diagnosis with lymphoma, germ cell tumor, granulomatosis with polyangiitis, sarcoidosis, histoplasmosis, and inflammatory myofibroblastic tumor.

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“…Five subtypes— G. morbillorum, G. haemosylans, G. sanguinis, G. bergeriae and G. taiwanesis —have been implicated 6 15 . Gemella spp have been associated with rare cases of life-threatening bacteraemia, necrotising fasciitis, brain abscesses and pneumonia, frequently in immunocompromised individuals 16–22. Notably, G. morbillorum decolourises easily during Gram staining and appears Gram-negative, potentially explaining why cases are rarely identified 5 23 24 .…”

Section: Discussionmentioning

confidence: 99%

Gemella morbillorummitral valve endocarditis in a patient with a history of mitral valve annuloplasty

Liu

Heid²,

Chandra³

et al. 2022

BMJ Case Rep

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A woman with a history of congenital heart disease status post multiple valve operations including mitral valve repair presented with 2 months of low back pain and general malaise. Blood cultures returned positive for Gram-positive cocci. While transthoracic echocardiography did not identify vegetations, transoesophageal echocardiography visualised vegetations on the patient’s mitral valve, which had previously undergone repair with annuloplasty. The patient was found to have infectious endocarditis (IE), caused by Gemella morbillorum. The patient was treated with over 6 weeks of intravenous antibiotics. Cases of Gemella-associated IE are rare and largely relegated to case reports. This report aims to contribute to the literature regarding this subject, and to further characterise the presentation and treatment of Gemella-associated IE. Additionally, this report emphasises the importance of maintaining a high suspicion of IE in a patient with non-specific malaise in the setting of prior cardiac valve operation.

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Pneumonia and bacteraemia caused by Gemella morbillorum in a previously healthy infant: first reported case in literature

Cited by 6 publications

References 11 publications

Gemella morbillorumas a source bacteria for necrotising fasciitis of the torso

Gemella morbillorumas a source bacteria for necrotising fasciitis of the torso

Endobronchial Infection and Bacterial Lymphadenitis by Gemella morbillorum Leading to Airway Perforation and a Bronchopleural Fistula

Gemella morbillorummitral valve endocarditis in a patient with a history of mitral valve annuloplasty

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