“Pneumomediastinum: A marker of severity in Covid-19 disease”

Khaire, Nivedita; Deshmukh, Suhas; Agarwal, Esha; Mahale, Nilesh; Khaladkar, Sanjay M; Desai, Sanjay; Kulkarni, Ashwini

doi:10.1016/j.heliyon.2023.e12981

Cited by 3 publications

(7 citation statements)

References 17 publications

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“…ventilation in patients with ARDS receiving high positive pressure ventilation (PPV) [110][111][112][113][114][115][116]. Pneumothorax (PNX) was found to co-exist with PMS in 40.3% of cases [110].…”

Section: Pneumomediastinum and Pneumothoraxmentioning

confidence: 99%

“…PMS has been identified as a complication in lung infections such as influenza and previous coronavirus infections such as SARS-CoV-1 and Middle East respiratory syndrome (MERS). It appears to be a marker of severe COVID-19 pneumonitis [ 110 , 111 ]. This condition can be spontaneous or secondary.…”

Section: Lung Complicationsmentioning

confidence: 99%

“…This condition can be spontaneous or secondary. The secondary form is the most common, with high incidence during the first three waves of the pandemic in critically ill patients ( Figure 15 ) and may be related to mechanical ventilation in patients with ARDS receiving high positive pressure ventilation (PPV) [ 110 , 111 , 112 , 113 , 114 , 115 , 116 ]. Pneumothorax (PNX) was found to co-exist with PMS in 40.3% of cases [ 110 ].…”

Section: Lung Complicationsmentioning

confidence: 99%

“…Subcutaneous emphysema is usually associated with PMS and PTX. The spontaneous forms of PMS and PNX have no apparent causes; however, several predisposing and precipitating factors have been identified, such as asthma, respiratory infections, lung cysts, inhaled drug use, corticosteroids, and the inhalation of irritants, as well as several anatomical predisposing alterations, including tracheomalacia [ 111 , 118 , 119 , 120 , 121 , 122 ]. Lung damage with alveolar rupture in COVID-19 infections can probably lead to interstitial pneumothorax, which can cause spontaneous PMS related to the Macklin effect [ 110 , 111 , 118 , 119 , 120 , 121 , 122 ].…”

Section: Lung Complicationsmentioning

confidence: 99%

“…The spontaneous forms of PMS and PNX have no apparent causes; however, several predisposing and precipitating factors have been identified, such as asthma, respiratory infections, lung cysts, inhaled drug use, corticosteroids, and the inhalation of irritants, as well as several anatomical predisposing alterations, including tracheomalacia [ 111 , 118 , 119 , 120 , 121 , 122 ]. Lung damage with alveolar rupture in COVID-19 infections can probably lead to interstitial pneumothorax, which can cause spontaneous PMS related to the Macklin effect [ 110 , 111 , 118 , 119 , 120 , 121 , 122 ]. In severe cases of COVID-19 pneumonia, parenchymal destruction can lead to the formation of cavitation and lung cysts, which can cause PTX and PMS after rupture [ 111 , 118 , 119 , 120 , 121 , 122 ].…”

Section: Lung Complicationsmentioning

confidence: 99%

See 4 more Smart Citations

A Pictorial Essay Describing the CT Imaging Features of COVID-19 Cases throughout the Pandemic with a Special Focus on Lung Manifestations and Extrapulmonary Vascular Abdominal Complications

Brogna

Bignardi

Megliola³

et al. 2023

Biomedicines

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With the Omicron wave, SARS-CoV-2 infections improved, with less lung involvement and few cases of severe manifestations. In this pictorial review, there is a summary of the pathogenesis with particular focus on the interaction of the immune system and gut and lung axis in both pulmonary and extrapulmonary manifestations of COVID-19 and the computed tomography (CT) imaging features of COVID-19 pneumonia from the beginning of the pandemic, describing the typical features of COVID-19 pneumonia following the Delta variant and the atypical features appearing during the Omicron wave. There is also an outline of the typical features of COVID-19 pneumonia in cases of breakthrough infection, including secondary lung complications such as acute respiratory distress disease (ARDS), pneumomediastinum, pneumothorax, and lung pulmonary thromboembolism, which were more frequent during the first waves of the pandemic. Finally, there is a description of vascular extrapulmonary complications, including both ischemic and hemorrhagic abdominal complications.

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Section: Pneumomediastinum and Pneumothoraxmentioning

confidence: 99%

Section: Lung Complicationsmentioning

confidence: 99%

Section: Lung Complicationsmentioning

confidence: 99%

Section: Lung Complicationsmentioning

confidence: 99%

Section: Lung Complicationsmentioning

confidence: 99%

See 3 more Smart Citations

A Pictorial Essay Describing the CT Imaging Features of COVID-19 Cases throughout the Pandemic with a Special Focus on Lung Manifestations and Extrapulmonary Vascular Abdominal Complications

Brogna

Bignardi

Megliola³

et al. 2023

Biomedicines

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Pneumomediastinum in COVID-19: Risk factors and outcomes from a multicentre case-control study

Negri,

Mazzuca,

Lococo

et al. 2024

Respiratory Medicine

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Pathological Presence of Free Air in the Thorax: Pneumothorax and Pneumomediastinum as a Complication of COVID-19

Cristea,

Zaharia,

Dumitrache-Rujinski

et al. 2023

Cureus

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Introduction: The abnormal presence of free air in the thorax, pneumothorax, and pneumomediastinum are complications for critically ill patients suffering from coronavirus disease 2019 (COVID-19). The development of these events may lead to a poor prognosis and make the management of this category of patients more difficult. Study design: We performed an observational retrospective study, including patients with SARS-CoV-2 infection and pneumonia who were hospitalized, to analyze the cases that developed pneumothorax or pneumomediastinum as a complication. Results: A total of 28 cases (1.51%) from 1844 patients with SARS-CoV-2 pneumonia developed pneumothorax or pneumomediastinum during hospitalization. Of them, 21 (75%) needed intensive care unit admission and ventilation, and 10 (35.71) were cured. Conclusion: The male gender is more probable to be involved in the development of pneumothorax or pneumomediastinum in patients with SARS-CoV-2 pneumonia. The incidence of these events is low, and conservative treatment could provide a better outcome.

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“Pneumomediastinum: A marker of severity in Covid-19 disease”

Cited by 3 publications

References 17 publications

A Pictorial Essay Describing the CT Imaging Features of COVID-19 Cases throughout the Pandemic with a Special Focus on Lung Manifestations and Extrapulmonary Vascular Abdominal Complications

A Pictorial Essay Describing the CT Imaging Features of COVID-19 Cases throughout the Pandemic with a Special Focus on Lung Manifestations and Extrapulmonary Vascular Abdominal Complications

Pneumomediastinum in COVID-19: Risk factors and outcomes from a multicentre case-control study

Pathological Presence of Free Air in the Thorax: Pneumothorax and Pneumomediastinum as a Complication of COVID-19

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