Pneumokoniosen

Hoffmeyer, Frank; Kampen, V. van; Brüning, Thomas; Merget, R.

doi:10.1055/s-2007-980153

Cited by 6 publications

(3 citation statements)

References 73 publications

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“…Ein Kausalzusammenhang mit einer vermuteten Exposition kann idealerweise durch zeitnahe Befunddokumentation sowie radiologisch mit Nachweis von milchglasartigen Trü- Expositionen gegenüber mineralischen Stäuben können entweder zu nicht funktionseinschrän-kenden "gutartigen Ablagerungen" führen (Siderose durch Eisenstäube, Stannose durch Zinnstäube) aber auch eine fibrogene Wirkung mit Ausbildung einer Pneumokoniose haben [8]. Grundsätzlich sind bei allen Pneumokoniosen Latenzzeiten bis zu 30 Jahren möglich, sodass die Arbeitsanamnese ab Berufsstart wichtig ist.…”

Section: Interstitielle Lungenerkrankungenunclassified

Arbeitsmedizin und Lunge

Ochmann

Nowak

2010

Pneumologe

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Etwa 9% aller Atemwegserkrankungen und 4% aller Lungentumoren sind auf Noxen am Arbeitsplatz zurückzuführen. Auch fibrotische Lungenparenchymveränderungen und exogen-allergische Alveolitiden können auf einer beruflichen Exposition beruhen. Jedoch stellen nicht alle Symptome Äquivalente einer Berufskrankheit dar. Wichtig ist, einen begründeten Verdacht auf eine Berufskrankheit vom großen Feld der arbeitsplatzassoziierten Beschwerden abgrenzen zu können. Schlüsselwörter AbstractApproximately 9% of all obstructive lung diseases and 4% of all lung cancers are attributable to workplace agents. Additionally, various forms of lung fibrosis including hypersensitivity pneumonitis can be caused by occupational exposure. However, only a minority of work-related symptoms can be equated to a formal occupational disease. Knowledge about differentiation between a suspected occupational disease and non-specific work-related findings is of major importance.

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Section: Interstitielle Lungenerkrankungenunclassified

Arbeitsmedizin und Lunge

Ochmann

Nowak

2010

Pneumologe

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“…These nano-sized particles may deposit in the alveoli of the lungs ( Donaldson et al, 2005 ; Day et al, 2008 ). Substances such as silica or the other nanoparticles generated during grinding dental materials have a fibro-genic potential and may cause lung fibrosis ( Hoffmeyer et al, 2007 ). They might further cross the biological barriers and enter the bloodstream, either through mobile cells or freely in the vasculature and lymph to directly harm distal organs causing lung cancer, pulmonary and cardio-vascular diseases, neurodegenerative diseases, asthma, increased mortality ( Sotiriou et al, 2008 ; Lelieveld et al, 2015 ; Cokic et al, 2020a ; Schraufnage, 2020 ; Calder'on-Garcidue˜nas et al, 2004 ; Von Klot et al, 2002 ; Maher et al, 2016 ; Tian et al, 2019 ) or even occupational disability in dental health care workers ( Leggat et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Ultrafine particles exposure is associated with specific operative procedures in a multi-chair dental clinic

Tang

Wen

Zhang

et al. 2022

Heliyon

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“…The initial inflammatory response is mediated by pulmonary macrophages activated after ingestion of silica particles. Activated macrophages release various inflammatory mediators including reactive oxygen species and attract neutrophils and lymphocytes thereby promoting alveolitis and tissue destruction [ 2 ]. Apoptosis, a tightly regulated form of programmed cell death, plays a pivotal role in tissue renewal and immune regulation and is mediated by Fas/Fas ligand (FasL) interaction [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary lesions and serum levels of soluble Fas (sCD95) in former hard coal miners

et al. 2010

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Objective Fas/APO-1 (CD95) and Fas Ligand (FasL) is a major mediator system that activates programmed cell death (apoptosis) and is most important for pulmonary cellular homeostasis. Another form of Fas, circulating soluble Fas (sCD95), produced by alternative mRNA splicing antagonizes the cell-surface Fas function. It was the aim of the study to test the hypothesis that the Fas/FasL system is implicated in the development of silica-induced pulmonary nodular lesions. Materials and methods We investigated the serum levels of sCD95 in 55 former hard coal miners. Coal workers' pneumoconiosis (CWP) was assumed when the profusion of small round opacities according to the ILO 2000 classification system was 1/1 or greater. Analyses of sCD95 were performed by a sandwich ELISA. Results Radiologic CWP was found in 34 of the 55 individuals. The age of subjects with and without CWP was similar (73.5 (SD 7.2) years vs . 73.5 (7.1) years; P = 0.924). sCD95 could be quantified in all samples; significantly higher levels were observed in subjects with radiologic signs of CWP (914 (752-1251) pg/ml vs . 632 (509-804) pg/ml, P < 0.001). However, there was no relationship between sCD95 serum concentrations and the quantity of profusion according to ILO. Conclusions The hypothesis of elevated sCD95 concentrations in CWP was corroborated. The usefulness of sCD95 for prevention and diagnosis of CWP and other forms of silica-induced fibrosis needs to be established By epidemiological studies.

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Pneumokoniosen

Cited by 6 publications

References 73 publications

Arbeitsmedizin und Lunge

Arbeitsmedizin und Lunge

Ultrafine particles exposure is associated with specific operative procedures in a multi-chair dental clinic

Pulmonary lesions and serum levels of soluble Fas (sCD95) in former hard coal miners

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