Pneumocystis primary infection in non-immunosuppressed infants in Lima, Peru

Ochoa, Theresa J.; Bustamante, Beatriz; García, Coralith; Neyra, Edgar; Mendoza, Karina; Calderón, E.; Gal, Solène Le; Miller, R F; Ponce, Carolina A.; Nevez, Gilles; Vargas, Sergio L.

doi:10.1016/j.mycmed.2021.101202

Cited by 3 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It demonstrates that a serological response to Pneumocystis is present across ages regardless of geographical location and suggests that infection, as measured by Msg antibody responses may be more prevalent in areas of Santiago with a poorer a socio-economic situation. Overcrowding conditions have been recently shown to be associated to increased colonization by Pneumocystis [26].…”

Section: Discussionmentioning

confidence: 99%

Sero-Epidemiology of Pneumocystis Infection among Infants, Children, and Adults in Chile

Miller

Daly

Walzer

et al. 2022

JoF

Self Cite

View full text Add to dashboard Cite

Previous serologic surveys show >80% of infants in Chile have anti-Pneumocystis antibodies by 2 years of age, but the seroepidemiology of Pneumocystis infection beyond infancy is unknown. We describe the sero-epidemiology in infants, children, and adults at different locations in Chile. Serum samples were prospectively obtained from 681 healthy adults (age ≥ 17 years) and 690 non-immunocompromised infants/children attending eight blood banks or outpatient clinics (2 in Santiago) in Chile. ELISA was used to measure serum IgM and IgG antibodies to Pneumocystis jirovecii major surface antigen (Msg) constructs MsgA and MsgC1. Serologic responses to Pneumocystis Msg showed a high frequency of reactivity, inferring infection. Among infants/children increasing age and the proportion with detectable IgM responses to MsgA, and IgG responses to MsgA, and MsgC1 were positively associated. Among adults there was almost universal seropositivity to one or more Pneumocystis Msg constructs. In infants and children rates of detectable IgM responses to MsgC1 and MsgA were greater than IgG responses. In Santiago, rates of seropositivity among infants/children were greater in clinics located in a more socio-economically deprived part of the city. In Chile, a serological response to Pneumocystis Msg constructs was common across ages regardless of geographical location and climatic conditions. Observed higher rates of IgM responses than IgG responses is consistent with concept of recent/ongoing exposure to Pneumocystis in children and adults. Higher rates of seropositivity in infants/children residing in more densely populated areas of Santiago infers crowding poses an increased risk of transmission.

show abstract

Section: Discussionmentioning

confidence: 99%