Pneumocystis jirovecii pneumonia complicated a case of SARS-CoV-2 infection and multiple sclerosis after treatment with rituximab

Zavareh, Mahmoud Sadeghi Haddad; Mehdinezhad, Hamed; Mehraeen, Rahele; Azizi, Mohammad Golparvar; Pirzaman, Ali Tavakoli

doi:10.22541/au.167524922.25244952/v1

Cited by 1 publication

(2 citation statements)

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“…A previous study found that without-a-known-reason secondary pneumonia could occur in about 30% of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected cases [3]. SARS-CoV-2 infection and its management with corticosteroids can disrupt the immune system's normal functioning, which could increase the risk of fungal infections [4,5]. Our previous case report showed that how incompetent immunity due to COVID-19 and rituximab could lead to a severe complication of Pneumocystis jirovecii pneumonia [4].…”

Section: Introductionmentioning

confidence: 99%

“…SARS-CoV-2 infection and its management with corticosteroids can disrupt the immune system's normal functioning, which could increase the risk of fungal infections [4,5]. Our previous case report showed that how incompetent immunity due to COVID-19 and rituximab could lead to a severe complication of Pneumocystis jirovecii pneumonia [4]. Furthermore, evidence highlights the danger of opportunistic fungi infections, such as pulmonary aspergillosis and mucormycosis, which can accompany viral symptoms and cause mortality by disrupting multiple organ systems [5].…”

Section: Introductionmentioning

confidence: 99%

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An unpremeditated complication of COVID-19 and mucormycosis: a case report, brief review, and warning for tunnel vision

Mehdinezhad

Ahangar

Azizi

et al. 2023

Preprint

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Over the course of the Coronavirus disease 2019 (COVID-19) pandemic, numerous complications have been documented. In this report, we have detailed an unexpected complication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that occurred in a 73-year-old female patient who was simultaneously afflicted with mucormycosis and another unanticipated problem. Due to the lack of recovery of the patient after receiving mucormycosis treatment and continued fever, cough and hemoptysis, bronchoscopy was performed for her. During bronchoscopy, we encountered a foreign body that was the cause of the patient's fever, cough, and hemoptysis. Rigid bronchoscopy was performed and a foreign body (2.7 x 1.2 cm) was removed from the left main bronchus. Although research has showed fewer cases of pediatric Foreign Body Aspiration (FBA) during lockdown periods, there is not enough evidence about FBA risk in elderly patients with comorbidities. Finally, in the treatment of cases of COVID-19 infections co-infected with opportunistic fungal and maybe even bacterial infections, we should not look at the patient through a tunnel vision and consider all possible scenarios for the patient.

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