1990
DOI: 10.1001/archinte.1990.00390140027007
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Pneumocystis carinii Pneumonia in Human Immunodeficiency Virus-Infected Patients

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Cited by 52 publications
(17 citation statements)
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References 95 publications
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“…Pneumocystis ccirinii pneumonia (PCP) is an important infection, causing morbidity and mortality in immuno compromised patients, especially AIDS patients [1 ]. Ad verse reactions to effective drugs such as trimethoprimsulfamethoxazole, clindamycin, pentamidine and trimetrexate have prompted a search for alternative therapeutic strategies [2].…”
Section: Introductionmentioning
confidence: 99%
“…Pneumocystis ccirinii pneumonia (PCP) is an important infection, causing morbidity and mortality in immuno compromised patients, especially AIDS patients [1 ]. Ad verse reactions to effective drugs such as trimethoprimsulfamethoxazole, clindamycin, pentamidine and trimetrexate have prompted a search for alternative therapeutic strategies [2].…”
Section: Introductionmentioning
confidence: 99%
“…or aerosolized pentamidine are accepted alternative therapies available for PCP prophylaxis for PBSC transplant recipients. [7][8][9] However, TMP/SMX intolerance may predict intolerance of dapsone, making dapsone a less desirable option. 10 Prophylactic therapy with i.v.…”
mentioning
confidence: 99%
“…10 Prophylactic therapy with i.v. or aerosolized pentamidine, while better tolerated, may be associated with multiorgan toxicity including alterations in glucose metabolism 9,11 and has been associated with atypical breakthrough infections. 12 Aerosolized pentamidine also requires experienced personnel for administration and careful patient monitoring.…”
mentioning
confidence: 99%
“…Different causes have been implicated in the development of PTX in patients with AIDS, namely: P. carinii infection [6,7,[13][14][15][16]; HIV itself, which can cause (probably through different mechanisms) a destructive action on the lung parenchyma, with alveolitis and "premature emphysema" [17]; and aerosolized pentamidine for PCP prophylaxis [8,9]. It has been suggested that aerosolized pentamidine leaves the apical areas of the lung untreated, and, if PCP develops, there is a progressive apical disease with large subpleural cavities, which may rupture and cause PTX [8].…”
Section: Discussionmentioning
confidence: 99%