Pneumococcal serum antibody concentrations during the first three years of life: a study of otitis-prone and non-otitis-prone children

Prellner, Karin; Kalm, Olof; Harsten, Göran; Heldrup, Jesper; Oxelius, Vivi‐Anne

doi:10.1016/0165-5876(89)90052-9

Cited by 41 publications

(21 citation statements)

References 23 publications

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“…Of the 101 patients examined for antibody against serotype 3, 18 had levels below the protective level of 200 ng/mL. For serotypes 14,19,23,26, and 51, the number of patients with antibody levels Ͻ200 ng/mL was 24, 11, 31, 15, and 16, respectively. The individual antibody levels of each patient for each serotype are depicted in There was a positive correlation between total serum IgG levels and age (Fig 2).…”

Section: Resultsmentioning

confidence: 99%

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Lahiri

Waltz

2001

Pediatrics

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ABSTRACT. Objective. Although invasive pneumococcal disease is infrequent in cystic fibrosis (CF), it is recommended that all patients with CF receive pneumococcal immunization. As part of a comprehensive program to immunize our clinic population, we obtained preimmunization anti-pneumococcal antibody levels. We hypothesized that the percentage of CF patients without protective levels of anti-pneumococcal antibody levels would be high, as they are exposed to frequent antibiotic therapy that may eradicate organisms before generation of an antibody response.Methods. An observational study of 100 patients with CF, aged 1 to 39 years, was conducted in a regional CF center. Preimmunization anti-pneumococcal antibody levels against 6 serotypes were measured by enzymelinked immunosorbent assay. Protective antibody levels were defined as >200 ng/mL.Results. A majority of CF patients-61% to 100%, depending on age and serotype-had protective levels of pneumococcal antibody. There was a significant positive correlation between antibody level and age for 5 of the 6 serotypes tested.Conclusions. In contradistinction to our hypothesis, the majority of CF patients have protective preimmunization anti-pneumococcal antibody levels. However, a significant proportion-between 17% and 39%, depending on the serotype-did not exhibit adequate levels. Therefore, we concur with current recommendations for pneumococcal immunization in CF. Pediatrics 2001; 108(4). URL: http://www.pediatrics.org/cgi/content/full/ 108/4/e62; cystic fibrosis, Streptococcus pneumoniae, immunization, ELISA.ABBREVIATIONS. CF, cystic fibrosis; ELISA, enzyme-linked immunosorbent assay; RIA, radioimmunoassay.

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Section: Resultsmentioning

confidence: 99%

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Lahiri

Waltz

2001

Pediatrics

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“…The role of laterality for the development of RAOM suggests, that the bilateral ear disease reflects more intense upper respiratory infection than unilateral cases do. The reasons of younger children having an unfavourable course of AOM can be immunological (13) and structural, due to narrower nasopharyngeal space and Eustachian tube lumen (14). In addition, young children have closer and more intimate physical contact with each other than do older children, and pressure to encounter respiratory viral infections, that predispose the children to AOM.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with the Development of Recurrent Acute Otitis Media - the Significance of Choosing the Right and Accurate Dependent and Independent Variables in the Multivariate Analysis

Jero

Kentala²,

Karma³

2000

Acta Oto-Laryngologica

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Jero J, Kentala E, Karma P. Factors associated with the de6elopment of recurrent acute otitis media -the significance of choosing the right and accurate dependent and independent 6ariables in the multi6ariate analysis. Acta Otolaryngol 2000; Suppl 543: 67 -69.The results of univariate and multivariate statistical analysis were compared in identifying predictive factors of the development of recurrent acuta otitis media (RAOM) after an initial episode of acute otitis media (AOM) in 121 children. Univariate correlations between the development of RAOM and potential risk factors were analysed, and variables at pB 0.10 were incorporated into the stepwise multiple logistic regression analysis. The comparisons between the univariate and multivariate analysis in identifying the predictive factors were made and the importance of changing the dependent variables in the multivariate analysis was analysed. It seems that univariate analysis is over-sensitive, but multivariate analysis is over-conservative in finding possible predictors of RAOM. Choosing the right and accurate dependent and independent variables in the multivariate analysis is extremely important, when this method is used.

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“…These children with recurrent otitis media had no differences in anti-H. infl uenzae type B and antimeasles antibody levels [18]. Prellner et al [19] drew serial blood samples from 113 children from birth until age 3 years. They were divided into three groups: 13 developed recurrent AOM, an intermediate group had a few ear infections, and 29 remained healthy.…”

Section: Otitis Media and Immunodefi Ciencymentioning

confidence: 99%

Otitis media as a presenting complaint in childhood immunodeficiency diseases

Wilson

Hogan²

2008

Curr Allergy Asthma Rep

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Otitis media is one of the most common childhood infections and may result from a variety of underlying problems. Suspicion of immunodeficiency should increase when ear infections are frequent; suppurative; unresponsive to antibiotics; caused by unusual organisms; or seen in the context of other frequent infections, severe eczema, or failure to thrive. Humoral immune deficiencies, particularly with an inability to make antibody to encapsulated organisms, are the immunodeficiencies most likely to cause increased otitis media. Immune system evaluation should concentrate on humoral immunodeficiency disorders, but the presenting history and physical findings also should be considered when designing the work-up. Treating the underlying immune deficiency is usually necessary to adequately control the ear infections.

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Pneumococcal serum antibody concentrations during the first three years of life: a study of otitis-prone and non-otitis-prone children

Cited by 41 publications

References 23 publications

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Factors Associated with the Development of Recurrent Acute Otitis Media - the Significance of Choosing the Right and Accurate Dependent and Independent Variables in the Multivariate Analysis

Otitis media as a presenting complaint in childhood immunodeficiency diseases

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