Pneumococcal sepsis as the first presentation of systemic lupus erythematosus (SLE) in a six year old boy

Elliott, Jessie A; Copeman, Annabel; Davies, Karen

doi:10.1136/adc.2011.212563.182

Cited by 2 publications

(3 citation statements)

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“…S. pneumoniae is the leading cause of pneumonia in SLE patients. In SLE patients, pneumococcal pneumonia is often severe, frequently acquiring a septicemic and fulminant course, occasionally described even at disease presentation [ 46 , 47 , 48 , 49 , 50 ]. For these reasons, a polyvalent pneumococcal vaccine is strongly recommended in SLE patients [ 51 ].…”

Section: Lung Infections In Systemic Rheumatic Diseasesmentioning

confidence: 99%

Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections

Franco

Lucchino

Spaziante

et al. 2017

IJMS

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Systemic rheumatic diseases have significant morbidity and mortality, due in large part to concurrent infections. The lung has been reported among the most frequent sites of infection in patients with rheumatic disease, who are susceptible to developing pneumonia sustained both by common pathogens and by opportunistic microorganisms. Patients with rheumatic disease show a peculiar vulnerability to infectious complications. This is due in part to intrinsic disease-related immune dysregulation and in part to the immunosuppressive treatments. Several therapeutic agents have been associated to a wide spectrum of infections, complicating the management of rheumatic diseases. This review discusses the most frequent pulmonary infections encountered in rheumatic diseases, focusing on opportunistic agents, consequent diagnostic challenges and appropriate therapeutic strategies.

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Section: Lung Infections In Systemic Rheumatic Diseasesmentioning

confidence: 99%

Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections

Franco

Lucchino

Spaziante

et al. 2017

IJMS

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“…SLE patients, especially those with hypocomplementemia, are at risk of infection with encapsulated bacteria. However, there are rare reports of severe invasive bacterial infection as the initial presentation of SLE [ 10 , 14 , 15 ]. It has been proposed that viral and bacterial infections may serve as environmental trigger for the development or exacerbation of SLE in the genetically predetermined individual [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recent evidence has revealed that bacterial DNA can promote several of the autoimmune abnormalities observed in SLE, and a possible pathogenic role in the induction of SLE has been highlighted [ 16 ]. We found only few reports of severe bacterial infection as a new SLE presentation in prior literature ( Table 1 ) [ 10 , 14 , 15 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Sometimes There Is More Than One Puzzle on the Table: Pneumococcal Bacteremia as a New Systemic Lupus Erythematosus Presentation

Sheybani

Naderi

Mirfeizi

et al. 2015

Case Reports in Infectious Diseases

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Infection is common and a leading cause of death in patients with systemic lupus erythematosus (SLE). SLE is associated with a diverse spectrum of immune impairments including humoral defects and hypocomplementemia that contribute to a lupus patient's increased susceptibility to infection with encapsulated bacteria. Nonetheless, there are only few reports of severe invasive bacterial infection as the initial presentation of SLE in the literature. Here, we report a rare case of SLE presenting with pneumococcal bacteremia. Based on the high resolution chest computed tomography and the result of blood cultures, the bacteremia was assumed to be secondary to pneumococcal pneumonia.

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Pneumococcal sepsis as the first presentation of systemic lupus erythematosus (SLE) in a six year old boy

Cited by 2 publications

References 0 publications

Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections

Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections

Sometimes There Is More Than One Puzzle on the Table: Pneumococcal Bacteremia as a New Systemic Lupus Erythematosus Presentation

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