Pneumococcal Pneumonia

Örtqvist, Åke

doi:10.1007/0-306-46834-4_27

Cited by 2 publications

(1 citation statement)

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“…However, since the present findings are based on the largest modern prospective series of patients with pneumococcal bacteraemia, obtained from many different countries and institutions during a 2‐year period, these data may offer the best current estimate of the risk for pneumococcal endocarditis in a non‐selected population. Assuming an incidence of pneumococcal bacteraemia of 20–50 cases/100 000/year [23], the corresponding incidence of pneumococcal endocarditis would be c. 1 – 3/1 million inhabitants/year. In a study among Alaskan natives, a higher incidence of pneumococcal endocarditis was found (1.5/100 000/year), but this population is at higher risk for invasive pneumococcal disease [24].…”

Section: Discussionmentioning

confidence: 99%

Endocarditis and pericarditis complicating pneumococcal bacteraemia, with special reference to the adhesive abilities of pneumococci: results from a prospective study

Kan

Ries

Normark

et al. 2006

Clinical Microbiology and Infection

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The incidence of pneumococcal cardiac infections is unknown and the pathogenicity of such complications is poorly understood. In a prospective, international, observational study, eight of 844 patients hospitalised with Streptococcus pneumoniae bacteraemia developed endocarditis (n = 5) or pericarditis (n = 3). The clinical and microbiological characteristics of these patients were compared with those of control patients. The corresponding incidence of pneumococcal endocarditis was c. 1-3/1 million inhabitants/year. There was no common pattern in the medical history of patients with an infectious cardiac complication. The severity of illness upon admission was comparable with that for patients without infectious cardiac complications, as was the 14-day mortality rate (25% and 17%, respectively). For encapsulated S. pneumoniae, no significant differences were found between patients with infectious cardiac complications and controls in adherence assays. However, non-encapsulated S. pneumoniae showed higher hydrophobicity and increased adherence to human epithelial cells.

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Section: Discussionmentioning

confidence: 99%