Pneumococcal conjugate vaccines for adults

Shapiro, Eugene D.

doi:10.4161/hv.28962

Cited by 13 publications

(6 citation statements)

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“…PPV23 reduces the risk of invasive pneumococcal diseases (IPDs) among adults; however, its effectiveness against pneumococcal pneumonia is still controversial, particularly for the elderly [ 37 ]. The recently approved PCV13 is expected to prevent almost half of the pneumococcal pneumonia cases in the elderly [ 38 , 39 ]; however, the vaccine covers only 13 serotypes of pneumococcus, and its long-term effects remain unknown. In Japan, before the introduction of PCV7 for children in 2010, 85% of IPD isolates were PPV23 serotypes, and 62% were PCV13 serotypes [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

The Burden and Etiology of Community-Onset Pneumonia in the Aging Japanese Population: A Multicenter Prospective Study

et al. 2015

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BackgroundThe increasing burden of pneumonia in adults is an emerging health issue in the era of global population aging. This study was conducted to elucidate the burden of community-onset pneumonia (COP) and its etiologic fractions in Japan, the world’s most aged society.MethodsA multicenter prospective surveillance for COP was conducted from September 2011 to January 2013 in Japan. All pneumonia patients aged ≥15 years, including those with community-acquired pneumonia (CAP) and health care-associated pneumonia (HCAP), were enrolled at four community hospitals on four major islands. The COP burden was estimated based on the surveillance data and national statistics.ResultsA total of 1,772 COP episodes out of 932,080 hospital visits were enrolled during the surveillance. The estimated overall incidence rates of adult COP, hospitalization, and in-hospital death were 16.9 (95% confidence interval, 13.6 to 20.9), 5.3 (4.5 to 6.2), and 0.7 (0.6 to 0.8) per 1,000 person-years (PY), respectively. The incidence rates sharply increased with age; the incidence in people aged ≥85 years was 10-fold higher than that in people aged 15-64 years. The estimated annual number of adult COP cases in the entire Japanese population was 1,880,000, and 69.4% were aged ≥65 years. Aspiration-associated pneumonia (630,000) was the leading etiologic category, followed by Streptococcus pneumoniae-associated pneumonia (530,000), Haemophilus influenzae-associated pneumonia (420,000), and respiratory virus-associated pneumonia (420,000), including influenza-associated pneumonia (30,000).ConclusionsA substantial portion of the COP burden occurs among elderly members of the Japanese adult population. In addition to the introduction of effective vaccines for S. pneumoniae and influenza, multidimensional approaches are needed to reduce the pneumonia burden in an aging society.

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Section: Discussionmentioning

confidence: 99%

The Burden and Etiology of Community-Onset Pneumonia in the Aging Japanese Population: A Multicenter Prospective Study

et al. 2015

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“…Recently, the Advisory Committee on Immunization Practices recommended routine use of PCV13 among adults aged ≥65 years in the United States [5]. However, because adults are indirectly protected when children receive PCVs, the fraction of IPD cases in adults that can be prevented declines over time, and it is not clear whether direct immunization of adults with the same vaccine would be effective [6,7].…”

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confidence: 99%

Association Between Local Pediatric Vaccination Rates and Patterns of Pneumococcal Disease in Adults

Pingali¹,

Warren²,

Mead³

et al. 2015

J Infect Dis.

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“…Although a 23-valent pneumococcal polysaccharide vaccine (PPV23) can reduce the risk of invasive pneumococcal diseases among adults, its effectiveness is still controversial (5). Additionally, the recently approved pneumococcal conjugate vaccine (PCV13) is expected to prevent approximately half of the pneumococcal pneumonia cases in the elderly (6, 7). In Japan, capsular serotypes 3 and 19F are the most and the third most common serotypes, respectively, isolated from adult patients with community-acquired pneumonia (8).…”

Section: Announcementmentioning

confidence: 99%

Complete Genome Sequences of Streptococcus pneumoniae Strains HU-OH (Serotype 3, Sequence Type 183 [ST183]), NU83127 (Serotype 4, ST246), and ATCC 49619 (Serotype 19F, ST1203)

Nagaoka

Konno

Murase

et al. 2019

Microbiol Resour Announc

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Pneumococcal conjugate vaccines for adults

Cited by 13 publications

References 13 publications

The Burden and Etiology of Community-Onset Pneumonia in the Aging Japanese Population: A Multicenter Prospective Study

The Burden and Etiology of Community-Onset Pneumonia in the Aging Japanese Population: A Multicenter Prospective Study

Association Between Local Pediatric Vaccination Rates and Patterns of Pneumococcal Disease in Adults

Complete Genome Sequences of Streptococcus pneumoniae Strains HU-OH (Serotype 3, Sequence Type 183 [ST183]), NU83127 (Serotype 4, ST246), and ATCC 49619 (Serotype 19F, ST1203)

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