Pneumococcal carriage in children in Ulaanbaatar, Mongolia before and one year after the introduction of the 13-valent pneumococcal conjugate vaccine

Mollendorf, Claire von; Dunne, Eileen M.; Vincente, Sophie La; Ulziibayar, Mukhchuluun; Suuri, Bujinlkham; Luvsantseren, Dashtseren; Narangerel, Dorj; Ortika, Belinda D.; Pell, Casey L; Nation, Monica Larissa; Alamrousi, Ahmed; Hinds, Jason; Demberelsuren, Sodbayar; Nguyen, Cattram; Mungun, Tuya; Mulholland, E. Kim; Satzke, Catherine

doi:10.1016/j.vaccine.2019.05.078

Cited by 24 publications

(29 citation statements)

References 36 publications

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“…Similar to our findings in Lao PDR, density of both PCV13 and non-PCV13 serotypes was higher in children following PCV13 introduction in Mongolia. [36] In contrast, density of both vaccine serotypes and non-vaccine serotypes declined in children in Fiji following the introduction of PCV10. [34] In an experimental human pneumococcal challenge model, adults who received PCV13 had lower pneumococcal density compared with those who received a control vaccine.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with pneumococcal carriage and density in infants and young children in Laos PDR

et al. 2019

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Nasopharyngeal carriage of Streptococcus pneumoniae (the pneumococcus) is a precursor to pneumococcal disease. Several host and environmental factors have been associated with pneumococcal carriage, however few studies have examined the relationship between host factors and pneumococcal carriage density. We sought to identify risk factors for pneumococcal carriage and density using data from cross-sectional pneumococcal carriage surveys conducted in the Lao People's Democratic Republic before and after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Nasopharyngeal swabs were collected infants from aged 5–8 weeks old (n = 999) and children aged 12–23 months (n = 1,010), pneumococci detected by quantitative PCR, and a risk factor questionnaire completed. Logistic and linear regression models were used to evaluate associations between participant characteristics and pneumococcal carriage and density. In infants aged 5–8 weeks, living in a household with two or more children under the age of five years (aOR 1.97; 95% CI 1.39–2.79) and low family income (aOR 1.64; 95% CI 0.99–2.72) were positively associated with pneumococcal carriage. For children aged 12–23 months, upper respiratory tract infection (URTI) symptoms (aOR 2.64; 95% CI 1.97–3.53), two or more children under five in the household (aOR 2.40; 95% CI 1.80–3.20), and rural residence (aOR 1.84, 95% CI 1.35–2.50) were positively associated with pneumococcal carriage. PCV13 vaccination was negatively associated with carriage of PCV13 serotypes (aOR 0.60; 95% CI 0.44–0.83). URTI symptoms (p < 0.001), current breastfeeding (p = 0.005), rural residence (p = 0.012), and delivery by Caesarean section (p = 0.035) were associated with higher mean pneumococcal density in pneumococcal carriers (both age groups combined). This study provides new data on pneumococcal carriage and density in a high disease burden setting in southeast Asia.

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Section: Discussionmentioning

confidence: 99%

Factors associated with pneumococcal carriage and density in infants and young children in Laos PDR

et al. 2019

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“…Examination of pneumococcal vaccination policies in other Asian countries may further inform ongoing pneumococcal vaccination strategies in the Philippines. In several countries in Asia, the introduction of PCV into the NIP has resulted in reduction in the incidence of IPD [59][60][61][62][63][64]. Specifically, in Mongolia, a study showed that before introduction of the vaccine, PCV13 serotypes accounted for up to 45% and 70% of all pneumococci tested in infants and children, respectively [59].…”

Section: Discussionmentioning

confidence: 99%

“…In several countries in Asia, the introduction of PCV into the NIP has resulted in reduction in the incidence of IPD [59][60][61][62][63][64]. Specifically, in Mongolia, a study showed that before introduction of the vaccine, PCV13 serotypes accounted for up to 45% and 70% of all pneumococci tested in infants and children, respectively [59]. Comparatively, in 2016, 1 year after the introduction of PCV13, vaccine serotype carriage in unvaccinated infants (aged 5 to 8 weeks) and children (aged 12 to 23 months) decreased by 51% and 52%, respectively [59].…”

Section: Discussionmentioning

confidence: 99%

A Narrative Review of Pneumococcal Disease in Children in the Philippines

et al. 2021

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“…In addition, the incidence of IPD caused by serotype 19A in children aged <5 years in Taiwan decreased by 32.6%-44.3% yearly between 2012 and 2017, and serogroup 15 was the most prevalent serotype in children aged <5 years in 2015 (Lu et al, 2019). In other Asian countries, including Cambodia, Mongolia, and the Lao People's Democratic Republic, evidence indicates that reductions occurred in the prevalence of pneumococcal carriage within 1-6 years after the introduction of PCV13 to children aged 5 weeks to 5 years (Suy et al, 2016;Satzke et al, 2019;von Mollendorf et al, 2019). The introduction of PCV13 resulted in decreases (28%-52%) in colonization by vaccine serotypes in children aged 5 weeks to 23 months (Su et al, 2016;Lu et al, 2019;Chen et al, 2019).…”

Section: Antibiotic Resistance By Pneumococcal Strainsmentioning

confidence: 99%

Pneumococcal disease in Thailand

Gamil¹,

Chokephaibulkit

Phongsamart

et al. 2021

International Journal of Infectious Diseases

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This review examines the epidemiology of pneumococcal disease, serotype prevalence, antibiotic resistance, and national vaccination recommendations in Thailand. The incidence of invasive pneumococcal disease (IPD) and annualized hospitalization rates for pneumococcal bacteremia in Thailand were highest in children aged <5 years and the elderly. The most prevalent serotype is serotype 6B, which is included in both the 10-and 13-valent pneumococcal conjugate vaccines (PCV10 [also known as PHiD-CV] and PCV13, respectively) registered in Thailand. Other common serotypes are 14, 18C, 19F, and 23F (included in both PCVs) and 6A and 19A (only included in PCV13). PCV10/PHiD-CV and PCV13 should cover 48.8%-74% and 73.2%-92% of isolates among children aged 5 years, respectively, and 40.0%-47.9% and 58.3%-60.9% of isolates among adults aged !65 years. Only PCV13 is licensed for adults in Thailand. Pneumococcal isolates were most commonly resistant to erythromycin, cefuroxime, and penicillin. Despite their demonstrated cost effectiveness and efficacy in reducing nasopharyngeal carriage and IPD, PCVs are not included in the Thai national immunization program. The serotype-specific IPD incidence in Thailand suggests that PCVs will reduce the disease burden in all age groups, but particularly in children and older adults.

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Pneumococcal carriage in children in Ulaanbaatar, Mongolia before and one year after the introduction of the 13-valent pneumococcal conjugate vaccine

Cited by 24 publications

References 36 publications

Factors associated with pneumococcal carriage and density in infants and young children in Laos PDR

Factors associated with pneumococcal carriage and density in infants and young children in Laos PDR

A Narrative Review of Pneumococcal Disease in Children in the Philippines

Pneumococcal disease in Thailand

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