Pneumococcal carriage among children after four years of routine 10-valent pneumococcal conjugate vaccine use in Brazil: The emergence of multidrug resistant serotype 6C

Neves, Felipe Piedade Gonçalves; Cardoso, Nayara Torres; Snyder, Robert E.; Marlow, Mariel; Cardoso, Claudete Aparecida Araújo; Teixeira, Lúcia Martins; Riley, Lee W.

doi:10.1016/j.vaccine.2017.04.019

Cited by 36 publications

(35 citation statements)

References 31 publications

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“…There was a slight but significant decrease in serotype 6A among children with AOM, which has been described in IPD among all ages following PHiD-CV vaccination ( 57 ). Serotypes 6C, 23A, and 23B were not affected by the vaccination, as these serotypes increased significantly in both sample groups, which has also been documented elsewhere ( 21 , 58 – 62 ).…”

Section: Discussionsupporting

confidence: 84%

“…Serotype 6C isolates detected PostVac most often belonged to CC315 6B and ST386 6C (a double locus variant [DLV] of PMEN Poland 6B -20). The MDR ST386 6C was detected in Spain 6 years after PCV7 implementation ( 69 ), and other countries have also reported the emergence of this lineage in nasopharyngeal carriage and IPD following the implementation of PHiD-CV ( 62 ). This lineage might be derived from a capsular switch from serotype 6B to serotype 6C, as has previously been reported by our group ( 36 ).…”

Section: Discussionmentioning

confidence: 98%

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Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland

et al. 2018

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 98%

Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland

et al. 2018

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“…with pneumococcal carriage after the introduction of PCV into national immunization schedules have reported age, poverty or proxies of poverty, number of young children living in the household, and symptoms of URTI as positively associated with pneumococcal carriage [41][42][43][44][45]. Previous studies have heterogenous findings regarding exposure to cigarette smoke and recent antibiotic use and their associations with pneumococcal carriage [5,11,[46][47][48][49][50][51][52][53].…”

Section: Plos Onementioning

confidence: 99%

Factors associated with pneumococcal carriage and density in children and adults in Fiji, using four cross-sectional surveys

et al. 2020

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This study describes predictors of pneumococcal nasopharyngeal carriage and density in Fiji. We used data from four annual (2012-2015) cross-sectional surveys, pre-and postintroduction of ten-valent pneumococcal conjugate vaccine (PCV10) in October 2012. Infants (5-8 weeks), toddlers (12-23 months), children (2-6 years), and their caregivers participated. Pneumococci were detected and quantified using lytA qPCR, with molecular serotyping by microarray. Logistic and quantile regression were used to determine predictors of pneumococcal carriage and density, respectively. There were 8,109 participants. Pneumococcal carriage was negatively associated with years post-PCV10 introduction (global P<0.001), and positively associated with indigenous iTaukei ethnicity (aOR 2.74 [95% CI 2.17-3.45] P<0.001); young age (infant, toddler, and child compared with caregiver participant groups) (global P<0.001); urban residence (aOR 1.45 [95% CI 1.30-2.57] P<0.001); living with �2 children <5 years of age (aOR 1.42 [95% CI 1.27-1.59] P<0.001); low family income (aOR 1.44 [95% CI 1.28-1.62] P<0.001); and upper respiratory tract infection (URTI) symptoms (aOR 1.77 [95% CI 1.57-2.01] P<0.001). Predictors were similar for PCV10 and non-PCV10 carriage, except PCV10 carriage was negatively associated with PCV10 vaccination (0.58 [95% CI 0.41-0.82] P = 0.002) and positively associated with exposure to household cigarette smoke (aOR 1.21 [95% CI 1.02-1.43] P = 0.031), while there was no association between years post-PCV10 introduction and non-PCV10 carriage. Pneumococcal density was positively associated with URTI symptoms (adjusted median difference 0.28 [95% CI 0.16, 0.40] P<0.001) and toddler and child, compared with caregiver, participant groups (global P = 0.008). Predictors were similar for PCV10 and non-PCV10 density, except infant, toddler, and child participant groups were not associated with PCV10 density. PCV10 introduction was associated with reduced the odds of overall and PCV10 pneumococcal carriage in Fiji. However, after adjustment iTaukei ethnicity was positively

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“…11 En los últimos años, se ha observado un aumento de la portación nasofaríngea de la cepa 6C posterior a la introducción de la vacuna 10-valente. 12 También, referente al desarrollo de infección invasora por neumococo, los serotipos 6C y 16F han sido los más prevalentes entre aquellos no incluidos en vacunas en población norteamericana y africana. 13 Con la introducción de la vacuna 13-valente, se cubre la cepa 19A, la cual es la más frecuentemente asociada al desarrollo de SHU por neumococo.…”

Section: Discussionunclassified

Glomerulonefritis infecciosa y pleuroneumonía por Streptococcus pneumoniae. Caso clínico pediátrico

2020

Arch Argent Pediat

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Presentación de casos clínicos RESUMEN La glomerulonefritis aguda desencadenada por Streptococcus pneumoniae es una patología de baja prevalencia. Existen diversos reportes que comunican distintas cepas nefritogénicas; sin embargo, la 6C ha sido escasamente señalada como tal. Se presenta el caso de un paciente de 4 años, quien ingresó a Terapia Intensiva con pleuroneumonía por Streptococcus pneumoniae serotipo 6C y desarrolló, de modo concomitante, edemas, hipertensión arterial, hematuria, proteinuria, disminución del filtrado glomerular y del nivel de complemento C3. Se diagnosticó glomerulonefritis aguda. Su evolución fue satisfactoria en un breve plazo. Esta patología, por lo general, es de curso transitorio y benigno; sin embargo, en ocasiones, puede complicar la evolución de un paciente críticamente enfermo, por lo cual se hace necesario tenerla entre los diagnósticos diferenciales para considerar.

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Pneumococcal carriage among children after four years of routine 10-valent pneumococcal conjugate vaccine use in Brazil: The emergence of multidrug resistant serotype 6C

Cited by 36 publications

References 31 publications

Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland

Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland

Factors associated with pneumococcal carriage and density in children and adults in Fiji, using four cross-sectional surveys

Glomerulonefritis infecciosa y pleuroneumonía por Streptococcus pneumoniae. Caso clínico pediátrico

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