Pneumatic dry granulation: potential to improve roller compaction technology in drug manufacture

Sandler, Niklas; Lammens, Robert F.

doi:10.1517/17425247.2011.548382

Cited by 24 publications

(20 citation statements)

References 34 publications

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“…Forming granules without moisture requires compacting and densifying powders. The dry method can be carried out using a tablet press and slugging tooling, or a roller compactor (Sandler and Lammens, 2011).…”

Section: Methodsmentioning

confidence: 99%

Control of response time of early-stage concrete with accelerator using granulation processing

Lee¹,

Ryou²

2015

Magazine of Concrete Research

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Although accelerators can be used to prevent early frost damage by developing the strength of concrete in cold weather, they do not lead to retention of workability because early hydration makes them react rapidly. In this study, granulation was used as a method to control the response time of the C 12 A 7 -based accelerator to retain the workability of fresh concrete. It was found that the workability of the granulated C 12 A 7 -based accelerator was retained for the operation time after mixing, and adequate strength was developed to prevent early frost damage.

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Section: Methodsmentioning

confidence: 99%

Control of response time of early-stage concrete with accelerator using granulation processing

Lee¹,

Ryou²

2015

Magazine of Concrete Research

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“…Also, this technology enables the use of high drug loads of up to 70-100%, because sufficient flowability could be achieved even at lower roll compaction forces (lower solid fractions) compared to usual roller compaction. 9 In addition to these, this technology avails various other benefits such as faster processing speed, low cost, little or no material wastage, low dust exposure due to the closed nature of this unit, etc. However, the influence of recycling on the granule quality, suitability with low dose formulations, friability, etc.…”

Section: Recent Progress In Dry Granulationmentioning

confidence: 99%

Granulation techniques and technologies: recent progresses

2017

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Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy to compress. Nevertheless, granulation poses numerous challenges due to high quality requirement of the formed granules in terms of content uniformity and physicochemical properties such as granule size, bulk density, porosity, hardness, moisture, compressibility, etc. together with physical and chemical stability of the drug. Granulation process can be divided into two types: wet granulation that utilize a liquid in the process and dry granulation that requires no liquid. The type of process selection requires thorough knowledge of physicochemical properties of the drug, excipients, required flow and release properties, to name a few. Among currently available technologies, spray drying, roller compaction, high shear mixing, and fluid bed granulation are worth of note. Like any other scientific field, pharmaceutical granulation technology also continues to change, and arrival of novel and innovative technologies are inevitable. This review focuses on the recent progress in the granulation techniques and technologies such as pneumatic dry granulation, reverse wet granulation, steam granulation, moisture-activated dry granulation, thermal adhesion granulation, freeze granulation, and foamed binder or foam granulation. This review gives an overview of these with a short description about each development along with its significance and limitations.

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“…This material is introduced into a newly innovated fractionating device that separates the granules and recycles rejected fraction. [24][25][26][27][28] Advantages…”

Section: Pneumatic Dry Granulation (Pdg)mentioning

confidence: 99%

Novel Techniques of Granulation: A Review

Muralidhar¹,

Bhargav²,

Sowmya³

2016

Int. Res. J. Pharm.

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Granulation is an important unit process in the production of pharmaceutical dosage forms like tablets, capsules and other dosage forms. Granulation process increases flow, compressibility and content uniformity of the powders. It inhibits the separation of blend components and reduces excessive amount of fine particles. This process helps to achieve improved yields with less tablet manufacturing defects. Particle size of granules depends on the quantity and feeding rate of the granulating liquid. Selecting a method of granulation requires comprehensive study of each ingredient in the formula, the combination of ingredients and their compatibility with each other is checked after, which appropriate granulation process can be applied. The recent technologies used for granulation include steam granulation, moisture activated dry granulation (MADG), moist granulation technique (MGT), extrusion-spheronization granulation, fluidized bed granulation, thermal adhesion granulation process (TAGP) and foam granulation etc. have their own advantages and overcome the disadvantages of conventional granulation process such as dust generation or deteriorating effect of heat as drying step. The objective of present work is to focus on the novel granulation technologies.

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Pneumatic dry granulation: potential to improve roller compaction technology in drug manufacture

Cited by 24 publications

References 34 publications

Control of response time of early-stage concrete with accelerator using granulation processing

Control of response time of early-stage concrete with accelerator using granulation processing

Granulation techniques and technologies: recent progresses

Novel Techniques of Granulation: A Review

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