PMSG/anti-PMSG in cattle: A simple and efficient superovulatory treatment?

Dieleman, S.J.; Bevers, M.M.; Vos, P.L.A.M.; Loos, F.A.M. de

doi:10.1016/0093-691x(93)90022-w

Cited by 59 publications

(28 citation statements)

References 43 publications

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“…The use of eCG in order to induce estrous synchronisation was previously restricted to one administration per year [16,18]. In superovulation protocols the frequency of injection was increased to one injection every two months and in ovum pick up protocols the frequency was highest with an injection weekly or twice a month.…”

Section: Discussionmentioning

confidence: 99%

“…In cattle, eCG is largely used in zootechnical programs in order to stimulate follicular growth and ovulation: treatment of anoestrus [19], synchronisation or induction of oestrus in combination with progestagens (400 to 600 IU once a year) [7,12], induction of superovulation (1 000 to 2 000 IU) [2,16,35] and more recently, stimulation of follicular growth in ovum pick-up programs (OPU) [15,21]. The higher doses and the higher frequency administration of eCG in OPU programs may have an influence on eCG antibody production in the cow and may induce a reduction in the efficiency of such treatments.…”

Section: Radiolabeling With 125 Iodinementioning

confidence: 99%

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Increase of plasma eCG binding rate after administration of repeated high dose of eCG to cows

Drion

Roover²,

Houtain³

et al. 2001

Reprod. Nutr. Dev.

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-Equine chorionic gonadotrophin (eCG) is still used to promote follicular growth in cattle and, more recently with an increased frequency of administration, in ovum pick-up protocols. The aim of this experiment was to verify the possible effect of high frequency of administration on the immune response to eCG. The profiles of eCG binding rate, in the blood of two groups (A, B) of 4 primiparous cross breed beef cows (3-3.5 years old) submitted weekly for 5 to 10 weeks to repeated high doses (1 000-2 000 IU) of equine chorionic gonadotrophin, are presented in this paper. A sensitive radiometric method was used to detect antibodies in plasma. The profiles clearly indicated a marked increase of eCG binding rate after 3 to 5 injections of the exogenous hormone to the females. The statistical analysis of the results established that treatments induced a significant increase (P < 0.01) in binding rates after 6 and 3 injections in group A and B respectively. These binding rates remained elevated for at least 1 week following the last injection and decreased afterwards. The values of plasma binding rates following repeated eCG administration differed significantly between groups (0.90 ± 1.04 and 1.04 ± 0.11 for groups A and B before treatment versus 11.77 ± 0.92, 6.70 ± 0.85 for groups A and B after treatment, P < 0.01) and from one cow to another (P < 0.01) with some cows presenting no significant immune response while others were more reactive against the hormone (at least 3 injections).cow / eCG / antibody Reprod. Nutr. Dev. 41 (2001) 207-215 207

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Section: Discussionmentioning

confidence: 99%

Section: Radiolabeling With 125 Iodinementioning

confidence: 99%

Increase of plasma eCG binding rate after administration of repeated high dose of eCG to cows

Drion

Roover²,

Houtain³

et al. 2001

Reprod. Nutr. Dev.

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“…It has been shown to have a half-life of 40 h in the cow and persists for up to 10 days in bovine circulation; thus it is normally injected once followed by a PGF injection, 48 h later [18]. The long halflife of eCG causes continued ovarian stimulation, unovulated follicles, abnormal endocrine profiles and reduced embryo quality [32,34,41].…”

Section: Gonadotrophins and Superovulationmentioning

confidence: 99%

Recent advances in the superovulation in cattle

Steward²,

2002

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mercial embryo transfer records. In a report of 2048 beef donor collections, a mean of 11.5 ova/embryos with 6.2 transferable embryos were collected from each cow [27]. However, the variability was great in both the superovulatory response and embryo quality; 24% of the collections did not produce viable embryos, 64% produced fewer INTRODUCTIONThe objective of superstimulatory treatments in the cow is to obtain a maximum number of fertilized and transferable embryos with a high probability of producing pregnancies [6]. Wide ranges in superovulatory response and embryo yield have been detailed in several reviews of com- Abstract -The variability in the superovulatory response continues to be one of the most frustrating problems with embryo transfer in cattle. The removal of LH from pituitary extracts has tended to reduce the variability in response, and several studies involving the use of the purified porcine pituitary extract, Folltropin ® -V are reviewed. The major source of variability in the superovulatory response in cattle is the status of ovarian follicles at the time of initiation of gonadotrophin treatments. Data support the benefits of initiating gonadotrophin treatments at the time of emergence of a follicular wave. Incorporation of techniques designed to control follicular wave dynamics, such as follicular ablation, or treatment with estradiol/progesterone, have reduced the variability caused by treating cows at different stages of follicular development, and at the same time improved response by taking advantage of endogenous recruitment and selection mechanisms. New protocols offer the convenience of being able to initiate gonadotrophin treatments quickly and at a self-appointed time, without the necessity of estrus detection and without sacrificing response. Methods can be used for repeated superstimulation of donor animals at 25 to 30 day intervals, without regard to estrus detection or stage of the estrous cycle, and without compromising embryo production. superstimulation / gonadotrophin / FSH / LH / follicular waves / embryo transfer / cattle Reprod. Nutr. Dev. 42 (2002) [601][602][603][604][605][606][607][608][609][610][611] 601 Communication

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“…Two different types of gonadotropin have generally been used for bovine superovulation, follicle stimulating hormone (FSH) and equine chorionic gonadotrophin (eCG). A single injection of eCG (2,500 IU) is sufficient to induce superovulation because of its long biological half-life (40 h; [1]). But the long half-life of eCG causes continued ovarian stimulation, unovulated follicles and abnormal endocrine profiles, resulting in reduced embryo quality [2][3][4].…”

mentioning

confidence: 99%

The Effect of Reduced Dose and Number of Treatments of FSH on Superovulatory Response in CIDR-Treated Korean Native Cows

Son

Choe

Cho

et al. 2007

Journal of Reproduction and Development

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Abstract. The objective of this study was to investigate the effect of dosage and number of days of follicle stimulating hormone (FSH) treatment on superovulatory response in controlled internal drug release (CIDR)-treated Korean native cows. Forty cows underwent two superovulatory treatments with a crossover design. Cows, at random stages of the estrous cycle, received a CIDR together with injections of 1 mg estradiol benzoate and 50 mg progesterone, and gonadotropin treatment began 4 days later. The cows were divided into 2 groups based on the dosage and number of days of treatment with porcine FSH; a total of 28 mg FSH was given in twice daily intramascular injections in decreasing doses over 4 days (5, 5, 4, 4, 3, 3, 2 and 2 mg; T1 group, n=20) or a total of 24 mg FSH was given in twice daily decreasing doses over 3 days (5, 5, 4, 4, 3 and 3 mg; T2 group, n=20). This was followed by the alternate treatment in the subsequent superovulation. The cows were treated identically in all other respects. PGF2α (25 mg and 15 mg) was given with the 5 th and 6 th injections of FSH, CIDR were withdrawn at the 6 th FSH injection and the cows received 200 µg GnRH 36 h after CIDR withdrawal. The cows were artificially inseminated twice, at 48 and 60 h after CIDR withdrawal, using commercial semen from four Korean native bulls, and embryos were recovered 6 or 7 days after the 2 nd insemination. The numbers of corpora lutea (CL; 7.9 ± 1.0 vs. 8.3 ± 1.1) and large follicles (1.2 ± 0.2 vs. 1.3 ± 0.3) present at the time embryo recovery, as detected by ultrasonography, did not differ between the T1 and T2 groups (P>0.05). Similarly, the numbers of total ova/embryos (6.2 ± 0.9 vs. 6.4 ± 1.1), transferable embryos (3.4 ± 0.8 vs. 3.2 ± 0.7), degenerate embryos (0.8 ± 0.2 vs. 1.0 ± 0.3) and unfertilized ova (2.1 ± 0.5 vs. 2.2 ± 0.5) did not differ between the groups (P>0.05). These data indicate that a reduced dose (24 vs. 28 mg) and number of treatments (6 vs. 8) of FSH for superovulation of CIDR-treated Korean native cows does not affect the embryo yield.

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PMSG/anti-PMSG in cattle: A simple and efficient superovulatory treatment?

Cited by 59 publications

References 43 publications

Increase of plasma eCG binding rate after administration of repeated high dose of eCG to cows

Increase of plasma eCG binding rate after administration of repeated high dose of eCG to cows

Recent advances in the superovulation in cattle

The Effect of Reduced Dose and Number of Treatments of FSH on Superovulatory Response in CIDR-Treated Korean Native Cows

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