PML Body Biogenesis: A Delicate Balance of Interactions
Sergey A. Silonov,
Eugene Y. Smirnov,
Irina M. Kuznetsova
et al.
Abstract:PML bodies are subnuclear protein complexes that play a crucial role in various physiological and pathological cellular processes. One of the general structural proteins of PML bodies is a member of the tripartite motif (TRIM) family—promyelocytic leukemia protein (PML). It is known that PML interacts with over a hundred partners, and the protein itself is represented by several major isoforms, differing in their variable and disordered C-terminal end due to alternative splicing. Despite nearly 30 years of res… Show more
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