PM288 Adherence to Secondary Prophylaxis for Patients Diagnosed With Rheumatic Heart Disease by Echocardiographic Screening

Culliford-Semmens, Nicola; Tilton, Elizabeth; Webb, Rachel; Lennon, Diana; Paku, B; Long, F; Malcolm, John A.; French, S W; Blair, Nikki; Wilson, N

doi:10.1016/j.gheart.2016.03.413

Cited by 10 publications

(12 citation statements)

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“…23 Furthermore, different studies reported reasons for poor adherence were lack of money, far distance from hospital, fear of medication side effects and painful injection, lack of awareness of the importance of BPG, and non-availability of BPG. 15,24,25 On the contrary, the adherence rate of the present study (80.6%) was less than that of Indian and New Zealand studies which reported (89.6%) 26 and (92%) 27 respectively. Another prospective study conducted in India also showed the overall adherence rate of 93.6%.…”

Section: Discussioncontrasting

confidence: 91%

Adherence to Benzathine Penicillin G Secondary Prophylaxis and Its Determinants in Patients with Rheumatic Heart Disease at a Cardiac Center of an Ethiopian Tertiary Care Teaching Hospital

Mekonen

Yismaw

Abiye

et al. 2020

PPA

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Purpose: Benzathine penicillin G (BPG) monthly administration is the most effective method for secondary prophylaxis against acute rheumatic fever (ARF). BPG's efficacy largely depends on adherence to treatment. This study was aimed at assessing adherence to BPG prophylaxis and its determinants among adult patients with rheumatic heart disease. Patients and Methods: An institutional cross-sectional study design was used. One hundred and forty-five patients receiving monthly BPG at the Adult Cardiac Clinic of Tikur Anbessa Specialized Hospital (TASH) were interviewed. Their 1-year BPG prophylaxis administration record was also reviewed. The rate of adherence to BPG injection was determined by calculating the percentage of the administered drug from the total expected doses. Data were entered and analyzed using Statistical Package for Social Sciences (SPSS) software version 25. Both descriptive and logistic regression analyses were computed to describe different variables and assess factors associated with adherence, respectively. A p-value <0.05 was used to declare association. Results: Among a total of 145 study participants involved, the majority (76.6%) of them had been receiving BPG for the last 10 years. The average adherence rate to monthly BPG injection was 80.60% with a range of 0% to 100%. However, only 101 (69.7%) of participants were taking ≥80% of their prescribed monthly BPG prophylaxis doses. Study participants with informal education 1.10 (0.023-46.96) and secondary school education 0.89 (0.10-8.11) were more and less likely to adhere to BPG injection, respectively, when compared with those who attended higher education programs. The regression analysis showed patients who were not admitted to the hospital (AOR: 26.22; CI: 2.55-269.70; p=0.006) and once admitted patients (AOR: 50.08; CI: 2.87-873.77; p=0.007) were more likely to adhere to their BPG injections than those admitted twice or more. The study participants who waited until the next appointment were also less adherent (AOR: 0.02; CI: 0.00-0.13; p=0.000) than those who went a few days later for receiving the missed/late dose. Conclusion: The adherence rate to BPG injection among RHD patients was found to be high (80.60%). Patients' admission status and their action on missed and/or late doses were found to be important determinants of adherence in this study.

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Section: Discussioncontrasting

confidence: 91%

Adherence to Benzathine Penicillin G Secondary Prophylaxis and Its Determinants in Patients with Rheumatic Heart Disease at a Cardiac Center of an Ethiopian Tertiary Care Teaching Hospital

Mekonen

Yismaw

Abiye

et al. 2020

PPA

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“…31 However, our figure was considerably higher than that found by Sayed (29.5%), 44 Thompson et al (48.7%), 48 Prasad et al (50%), 46 Musoke et al (54%), 53 Gasse et al (54%), 38 Mohammed et al (55.2%), 29 Huck et al (58%), 43 and Harrington et al (59%). 34 On the other hand, it was considerably less than of Saxena et al (93.6%), 52 Culliford-Semmens et al (92%), 54 Kumar et al (90%), 45 Mekonnen et al (80.6%), 37 and Sial et al (73.5%). 55 Abbreviations: RHD, rheumatic heart disease; NYHA, New York Heart Association.…”

Section: Discussionmentioning

confidence: 78%

Rheumatic Heart Disease Patients’ Adherence to Secondary Prophylaxis and Associated Factors at Hospitals in Jimma Zone, Southwest Ethiopia: A Multicenter Study

Adem¹,

Gemechu²,

Jarso³

et al. 2020

PPA

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Background: Rheumatic heart disease (RHD) is a major cause of preventable premature cardiovascular-related death in developing countries. However, information regarding adherence rates and associated factors is limited and inconsistent in Ethiopia. Methods: A cross-sectional study was conducted from August to November 2019 among selected RHD patients on follow-up at four hospitals in Jimma zone. Data were collected using a structured questionnaire. Adherence of RHD patients to secondary prophylaxis in the previous consecutive 12 months was assessed based on the annual frequency of received prophylaxis (monthly injection of benzathine penicillin). Good adherence was considered the patient receiving >80% of the annual dose. The collected data were entered into Epidata 3.1 and analysed using SPSS 23. Results: A total of 253 RHD patients taking prophylaxis were included in the analysis, and of those 178 (70.4%) were female, giving a male:female ratio of 1:2.4. The mean age was 24 ±11 (6-65) years. About 63% had good adherence to benzathine penicillin prophylaxis. New York Heart Association functional class I and II, rural residence, >30 km from health facility, and duration of prophylaxis >5 years were associated with poor adherence (respectively: AOR 12.6 [95% CI 2.5-63], P=0.

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“…(92%) due to the socio-demographic difference of our patients and New Zealand and design difference (29,30) . Opposing the finding of the present study, highest adherence of RHD patients to secondary prophylaxis was also reported by studies of Sial et al (73.5%), Saxena et al (93.6%) may be due to study design and sociodemographic difference (31,32) .…”

Section: Research Articlementioning

confidence: 97%

Adherence of Rheumatic Heart Disease Patients to Secondary Prophylaxis and Main Reasons for Poor Adherence at Jimma Medical Center

Mohammed¹,

Demissie²,

Gare³

2019

ejcm

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Objectives: Rheumatic heart disease (RHD) is the major long-term sequel of acute rheumatic fever (ARF), which involves the cardiac valves leading to stenosis or regurgitation with resultant hemodynamic disturbance. The incidence of ARF and prevalence RHD in the sub-Saharan Africa including Ethiopia are amongst the highest in the world. The main priority of long-term management of ARF or RHD is to ensure that patients are adherent to the secondary prophylaxis which is monthly benzathine penicillin injection to prevent recurrent attacks of ARF. Materials and Methods: A cross-sectional study was conducted among sampled 241 RHD patients having at least one year follow-up at cardiac clinic of Jimma Medical Center (JMC) who appointed every month to receive injections of antibiotic prophylaxis. The data was collected for 4 months (from June 1-September 30, 2018) by asking their follow-up status of last one year retrospectively and assessing related variables by using face to face interview. After the data was collected using structured questionnaires, it was coded, entered into Epi data and exported to SPSS for further analysis. The adherence rate of RHD patients was determined by frequency of annual injections of prophylaxis.

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PM288 Adherence to Secondary Prophylaxis for Patients Diagnosed With Rheumatic Heart Disease by Echocardiographic Screening

Cited by 10 publications

References 0 publications

<p>Adherence to Benzathine Penicillin G Secondary Prophylaxis and Its Determinants in Patients with Rheumatic Heart Disease at a Cardiac Center of an Ethiopian Tertiary Care Teaching Hospital</p>

<p>Adherence to Benzathine Penicillin G Secondary Prophylaxis and Its Determinants in Patients with Rheumatic Heart Disease at a Cardiac Center of an Ethiopian Tertiary Care Teaching Hospital</p>

<p>Rheumatic Heart Disease Patients’ Adherence to Secondary Prophylaxis and Associated Factors at Hospitals in Jimma Zone, Southwest Ethiopia: A Multicenter Study</p>

Adherence of Rheumatic Heart Disease Patients to Secondary Prophylaxis and Main Reasons for Poor Adherence at Jimma Medical Center

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