PM2.5 induces renal tubular injury by activating NLRP3-mediated pyroptosis

Chen, Weilin; Luo, Yanfang; Quan, Jingjing; Zhou, Ji; Yi, Bin; Huang, Zhijun

doi:10.1016/j.ecoenv.2023.115490

Cited by 4 publications

(3 citation statements)

References 51 publications

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“…Poor air quality in the city of Pavlodar has a negative impact on public health. Exposure to PM2.5 and PM10 can cause various health problems, including respiratory diseases (Tatayeva & Burumbayeva, 2014;Wang et al, 2021;Yan et al, 2022), cardiovascular diseases (Huang & Chen, 2021;Ren et al, 2021), stroke (Chen et al, 2023;Gale et al, 2020), and cancer (Oh et al, 2023;Zhang et al, 2023;Zhou, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Air pollution is a global public health challenge, affecting urban areas across the world. It is a leading environmental risk factor, contributing to a wide range of health problems, including respiratory diseases (such as asthma and chronic obstructive pulmonary disease) (Tatayeva & Burumbayeva, 2014;Wang et al, 2021;Yan et al, 2022), cardiovascular diseases (including heart attacks and strokes) (Chen et al, 2023;Gale et al, 2020;Huang & Chen, 2021;Ren et al, 2021), lung cancer (Oh et al, 2023;Zhang et al, 2023;Zhou, 2021), and a variety of other adverse health outcomes. Poor air quality is responsible for millions of premature deaths each year worldwide (Goodwin, 2023;Roy, 2018;Van Der Wall, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spatial Distribution of PM2.5 and Pm10 Pollutants in Residential Area of Pavlodar, Kazakhstan

Safarov,

Shomanova,

Kopishev

et al. 2023

SCT

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doctor of chemistry, professor, academician of NAS RK, president of NAS RK, general director of JSC "Institute of fuel, catalysis and electrochemistry named after D.V. Sokolsky (Almaty, Kazakhstan) H = 4 Editorial board: ADEKENOV Sergazy Mynzhasarovich (deputy editor-in-chief) doctor of chemical sciences, professor, academician of NAS RK, director of the international Scientific and production holding «Phytochemistry» (Karaganda, Kazakhstan) H = 11 AGABEKOV Vladimir Enokovich (deputy editor-in-chief), doctor of chemistry, professor, academician of NAS of Belarus, honorary director of the Institute of Chemistry of new materials (Minsk, Belarus) H = 13 STRNAD Miroslav, head of the laboratory of the institute of Experimental Botany of the Czech academy of sciences, professor (Olomouc, Czech Republic) H = 66 BURKITBAYEV Mukhambetkali, doctor of chemistry, professor, academician of NAS RK, first vice-rector of al-Farabi KazNU (Almaty, Kazakhstan) H = 11 HOHMANN Judith, head of the department of pharmacognosy, faculty of Pharmacy, university of Szeged, director of the interdisciplinary center for Life sciences (Szeged, ungary) H = 38 ROSS Samir, Ph.D, professor, school of Pharmacy, national center for scientific research of Herbal Products, University of Mississippi (Oxford, USA) H = 35 KHUTORYANSKY Vitaly, Ph.D, pharmacist, professor at the University of Reading (Reading, England) H = 40 TELTAYEV Bagdat Burkhanbayuly, doctor of technical sciences, professor, corresponding member of NAS RK, ministry of Industry and infrastructure development of the Republic of Kazakhstan (Almaty, Kazakhstan) H = 13 PHARUK Asana Dar, professor at Hamdard al-Majid college of Oriental medicine. faculty of Oriental medicine, Hamdard university (Karachi, Pakistan) H = 21 FAZYLOV Serik Drakhmetovich, doctor of chemistry, professor, academician of NAS RK, deputy director for institute of Organic synthesis and coal chemistry (Karaganda, Kazakhstan) H = 6 ZHOROBEKOVA Sharipa Zhorobekovna, doctor of chemistry, professor, academician of NAS of Kyrgyzstan, Institute of Chemistry and chemical technology of NAS KR (Bishkek, Kyrgyzstan) H = 4 KHALIKOV Jurabay Khalikovich, doctor of chemistry, professor, academician of the academy of sciences of tajikistan, institute of Chemistry named after V.I. Nikitin AS RT (Tajikistan) H = 6 FARZALIEV Vagif Medzhid ogly, doctor of chemistry, professor, academician of NAS of Azerbaijan (Azerbaijan) H = 13 GARELIK Hemda, PhD in chemistry, president of the department of Chemistry and Environment of the International Union of Pure and Applied Chemistry (London, England) H = 15 News of the National Academy of Sciences of the Republic of Kazakhstan. Series of chemistry and technology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spatial Distribution of PM2.5 and Pm10 Pollutants in Residential Area of Pavlodar, Kazakhstan

Safarov,

Shomanova,

Kopishev

et al. 2023

SCT

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show abstract

“…Water-soluble ions in PM 2.5 significantly impact weather and visibility [6], while metals, PAHs, and their derivatives harm human health [2,7,8]. The characteristics and chemical composition of PM 2.5 pollution in different cities and seasons are significantly different, which leads to complex health hazards and toxicological mechanisms induced by PM 2.5 [9][10][11]. Taiyuan is a typical resource-based city in northern China.…”

Section: Introductionmentioning

confidence: 99%

Pollution Characteristics of Different Components of PM2.5 in Taiyuan during 2017–2020 Wintertime and Their Toxicity Effects on HepG2 Cells

Bai,

Zhang,

Chen

et al. 2023

Atmosphere

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Fine particulate matter (PM2.5) is a common pollutant, and its health risk has attracted much attention. Studies have shown that PM2.5 exposure is associated with liver disease. The composition of PM2.5 is complex, and its hepatotoxic effects and lipid metabolism process are not well understood. In this study, we detected the concentrations of PM2.5 and its components (metals and polycyclic aromatic hydrocarbon (PAHs)) in the winter in Taiyuan, Shanxi Province, China, from 2017 to 2020 and then assessed the health risks. We also investigated the effects of different components (whole particles (WP), water-soluble particles (WSP), organic particles (OP)) of PM2.5 on the cytotoxicity and lipid metabolism in human liver cell line (HepG2) after 24 h of treatment. The changes in cytotoxicity indexes (LDH, IL-6, reactive oxygen species (ROS)) and lipids (triglyceride (TG), free fatty acid (FFA)) were measured after 24 h. The mRNA expression of lipid metabolism-related factors (SREBP1, CD36, MTTP) was determined by real-time quantitative RT-qPCR. Finally, the correlation between metals and PAHs with higher PM2.5 content in 4 years and biomarkers was analyzed. The results showed that: (1) The PM2.5 pollution was severe in Taiyuan during winter in 2017 and the subsequent four years. The calculation results of the metal enrichment factor (EF) value and PAHs characteristic ratio of PM2.5 showed that PM2.5 pollution sources differed in different years. (2) Exposure to metals and PAHs in PM2.5 did not cause a non-carcinogenic risk. Metals had no cancer risk, while PAHs inhaled in PM2.5 in 2017 and 2018 had a potential cancer risk. The atmospheric PM2.5 pollution in Taiyuan has had a downward trend, but the PAHs in the PM2.5 of 2017–18, when the pollution is relatively serious, have a potential carcinogenic risk. (3) WP, OP and WSP inhibited cell survival rate from 2017 to 2020, and OP had higher cytotoxicity at the same concentration. (4) WP, OP and WSP increased the levels of LDH, IL-6, TNF-α, ROS, MDA, TG and FFA, and inhibited SOD activity in a dose-effect relationship. The organic components in PM2.5 are more toxic to HepG2 cells and affect the expression of lipid metabolism-related factors at the transcriptional level. (5) The mRNA expressions of factors related to lipid synthesis, uptake, oxidation and output were up-regulated after treatment with PM2.5 and its components, suggesting a lipid metabolism disorder. (6) The biomarkers were associated with certain metals (Zn, Pb, Cu and Cr) and PAHs in PM2.5. These suggested that PM2.5- and PM2.5-bound organic matter caused HepG2 cytotoxicity and affected lipid metabolism.

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Association of acute exposure to PM2.5 constituents and sources with kidney injury: A longitudinal panel study of Nrf2 promoter polymorphism

Xu,

Zhang,

et al. 2024

Journal of Hazardous Materials

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PM2.5 induces renal tubular injury by activating NLRP3-mediated pyroptosis

Cited by 4 publications

References 51 publications

Spatial Distribution of PM2.5 and Pm10 Pollutants in Residential Area of Pavlodar, Kazakhstan

Spatial Distribution of PM2.5 and Pm10 Pollutants in Residential Area of Pavlodar, Kazakhstan

Pollution Characteristics of Different Components of PM2.5 in Taiyuan during 2017–2020 Wintertime and Their Toxicity Effects on HepG2 Cells

Association of acute exposure to PM2.5 constituents and sources with kidney injury: A longitudinal panel study of Nrf2 promoter polymorphism

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