PM2.5 exposure in association with AD-related neuropathology and cognitive outcomes

Thiankhaw, Kitti; Chattipakorn, Nipon

doi:10.1016/j.envpol.2021.118320

Cited by 76 publications

(46 citation statements)

References 61 publications

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“…Excessive oxidative stress and inflammatory response modified brain proteins and caused mild cognitive dysfunction and AD. In addition, some research has reported that PM 2.5 is associated with the development of AD and AD-related neuropathology [ 5 , 6 ]. Aβ and tau are considered specific biomarkers of AD [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Systemic inflammation factors produced by PMs such as pro-inflammatory cytokines (interferon (IFN)-γ, interleukin (IL)-6 IL-1β, and tumor necrosis factor (TNF)-α), enter the brain through the blood-brain barrier (BBB) and activate the microglia. Furthermore, PM 2.5 can directly reach the brain through the olfactory bulb, and it induces the destruction of the BBB by suppressing the expression levels of tight junction-related proteins [ 5 , 6 ]. The disrupted BBB can allow peripheral inflammatory or toxicity-associated substances to easily reach the brain [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Porphyra tenera Protects against PM2.5-Induced Cognitive Dysfunction with the Regulation of Gut Function

et al. 2022

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To evaluate the biological effects of Porphyra tenera (P. tenera), we tried to confirm the possibility that the intake of P. tenera could modulate cognitive and intestinal functions in PM2.5-induced cognitive decline mice. P. tenera attenuated PM2.5-induced learning and memory impairment through antioxidant and anti-inflammatory effects by regulating the mitochondrial function and TLR-initiated NF-κB signaling. In addition, P. tenera effectively alleviated Aβ production/tau phosphorylation by inhibiting the JNK phosphorylation. Also, the bioactive constituents of P. tenera determined the sulfated galactan, mycosporine-like amino acids (MAAs), and chlorophyll derivatives. Moreover, the bioactive compounds of P. tenera by gut fermentation protected against gut dysbiosis and intestinal tight junction damage with a decrease in inflammatory response and short-chain fatty acid production. Based on these results, our findings suggest that P. tenera with sulfated galactan and MAAs is a potential material for cognitive function improvement.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Porphyra tenera Protects against PM2.5-Induced Cognitive Dysfunction with the Regulation of Gut Function

et al. 2022

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“…In vitro studies provide insights into in-depth cellular and molecular mechanisms by which PM exposure promotes cellular damage and abnormality, linking to neurodegenerative disorders, such as the alterations of cell viability and apoptosis, the dysfunction of mitochondria, the production of ROS, or the release of pro-inflammatory mediators [ 1 , 17 ]. Thus far, neuronal and microglial cell lines, primary cultures or co-culture of those cells have been introduced for exposure to concentrated ambient air particles, DEP, and LPS, among others [ 95 ] ( Table 3 ).…”

Section: Evidence From In Vitro Studiesmentioning

confidence: 99%

Microglial Activation and Oxidative Stress in PM2.5-Induced Neurodegenerative Disorders

Song

Han

Wang³

et al. 2022

Antioxidants

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Fine particulate matter (PM2.5) pollution remains a prominent environmental problem worldwide, posing great threats to human health. The adverse effects of PM2.5 on the respiratory and cardiovascular systems have been extensively studied, while its detrimental effects on the central nervous system (CNS), specifically neurodegenerative disorders, are less investigated. Neurodegenerative disorders are characterized by reduced neurogenesis, activated microglia, and neuroinflammation. A variety of studies involving postmortem examinations, epidemiological investigations, animal experiments, and in vitro cell models have shown that PM2.5 exposure results in neuroinflammation, oxidative stress, mitochondrial dysfunction, neuronal apoptosis, and ultimately neurodegenerative disorders, which are strongly associated with the activation of microglia. Microglia are the major innate immune cells of the brain, surveilling and maintaining the homeostasis of CNS. Upon activation by environmental and endogenous insults, such as PM exposure, microglia can enter an overactivated state that is featured by amoeboid morphology, the over-production of reactive oxygen species, and pro-inflammatory mediators. This review summarizes the evidence of microglial activation and oxidative stress and neurodegenerative disorders following PM2.5 exposure. Moreover, the possible mechanisms underlying PM2.5-induced microglial activation and neurodegenerative disorders are discussed. This knowledge provides certain clues for the development of therapies that may slow or halt the progression of neurodegenerative disorders induced by ambient PM.

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“…Following many previous syntheses on the topic, the most recent [51] continues to demonstrate an increased risk of cognitive decline particularly from increasing PM2.5, whereas the associations with dementia, and from other pollutants are less consistent. Specific patterns of cognitive profiles associated with the highest exposure to multiple air pollutants, and neuroimaging studies, have shown incongruenties [52 ▪ ,53–55].…”

Section: Epidemiological Associations Between Air Pollutants and Ment...mentioning

confidence: 99%

Air pollution and mental health: associations, mechanisms and methods

King

Zhang

Cohen

2021

Current Opinion in Psychiatry

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Purpose of reviewThere is increasing interest in the links between exposure to air pollution and a range of health outcomes. The association with mental health however is much less established. This article reviews developments in the field over the past 12 months, highlighting the evidence for causation, associations between multiple air pollutants and mental health outcomes, and assesses the challenges of researching this topic. Recent findingsIncreasingly rigorous methods are being applied to the investigation of a broader range of mental health outcomes. These methods include basic science, neuroimaging, and observational studies representing diverse geographical locations. Cohort studies with linked high-resolution air pollutant exposure data are common, facilitating advanced analytic methods. To date, meta-analyses have demonstrated small and significant positive associations between long-term exposure to fine particulate matter and depressive symptoms and cognitive decline. Methodological complexities in measuring exposure and outcome pose ongoing difficulties for the field.

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PM2.5 exposure in association with AD-related neuropathology and cognitive outcomes

Cited by 76 publications

References 61 publications

Porphyra tenera Protects against PM2.5-Induced Cognitive Dysfunction with the Regulation of Gut Function

Porphyra tenera Protects against PM2.5-Induced Cognitive Dysfunction with the Regulation of Gut Function

Microglial Activation and Oxidative Stress in PM2.5-Induced Neurodegenerative Disorders

Air pollution and mental health: associations, mechanisms and methods

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