PM2.5 and constituent component impacts on global DNA methylation in patients with idiopathic pulmonary fibrosis

Goobie, G.C.; Li, Xiaoyun; Ryerson, Christopher J.; Carlsten, Christopher; Johannson, Kerri A.; Fabisiak, James P.; Lindell, Kathleen O.; Chen, Xiaoping; Gibson, Kevin F.; Kass, Daniel J.; Nouraie, S.M.; Zhang, Yingze

doi:10.1016/j.envpol.2022.120942

Cited by 7 publications

(6 citation statements)

References 47 publications

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“…Studies were conducted across various countries, representing diversity of geography, culture, and population ethnicity ( Table 2 ). Six studies were conducted in the United States ( 44 , 46 , 48–50 , 62 ), representing a quarter of all the included studies. Three studies were conducted each in Spain ( 53 , 54 , 63 ) and South Korea ( 43 , 57 , 64 ).…”

Section: Resultsmentioning

confidence: 99%

“…Among the 24 studies incorporated in the analysis, seven studies scrutinized the link between short-term exposure to air pollution and its impact on health outcomes ( 43 , 46 , 49 , 51 , 55 , 59 , 60 ). Fourteen studies delved into the connection between long-term exposure to air pollution and health outcomes ( 44 , 45 , 48 , 50 , 52 , 54 , 56–58 , 62 , 64–66 ). The remaining three studies examined the effects of both short-term and long-term exposure ( 47 , 53 , 63 ).…”

Section: Resultsmentioning

confidence: 99%

“…NOS scores were assigned to each study by consensus. Among the appraised 18 studies, 12 received a full score of 9/9 ( 43 , 44 , 47 , 48 , 50 , 56–58 , 61 , 62 , 65 , 66 ), indicating high quality research. Four studies received a score of 8/9 ( 49 , 52 , 53 , 64 ), one study received a score of 7/9 ( 55 ), and one study was scored as 6/9 ( 46 ).…”

Section: Resultsmentioning

confidence: 99%

“…Six studies involving 8,546 participants examined the association between air pollution and mortality in individuals with IPF ( 43 , 47 , 53 , 57 , 63 ) or fILD ( 58 ). Among these studies, five studies investigated NO 2 ( 43 , 47 , 53 , 57 , 63 ), four studies involved O 3 ( 43 , 47 , 53 , 63 ), and three studies each examined PM 10 ( 47 , 53 , 57 ), and PM 2.5 ( 47 , 53 , 62 ).…”

Section: Resultsmentioning

confidence: 99%

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The impact of air pollution on interstitial lung disease: a systematic review and meta-analysis

Lan,

Fermoyle,

Troy

et al. 2024

Front. Med.

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IntroductionThere is a growing body of evidence suggesting a causal relationship between interstitial lung disease (ILD) and air pollution, both for the development of the disease, and driving disease progression. We aim to provide a comprehensive literature review of the association between air pollution, and ILD, including idiopathic pulmonary fibrosis (IPF).MethodsWe systematically searched from six online database. Two independent authors (DL and CF) selected studies and critically appraised the risk of bias using the Newcastle-Ottawa Scale (NOS). Findings are presented through a narrative synthesis and meta-analysis. Meta-analyses were performed exclusively when there was a minimum of three studies examining identical pollutant-health outcome pairs, all evaluating equivalent increments in pollutant concentration, using a random effects model.Results24 observational studies conducted in 13 countries or regions were identified. Pollutants under investigation encompassed ozone (O3), nitrogen dioxide (NO2), Particulate matter with diameters of 10 micrometers or less (PM10) and 2.5 micrometers or less (PM2.5), sulfur dioxide (SO2), carbon monoxide (CO), nitric oxide (NO) and nitrogen oxides (NOx). We conducted meta-analyses to assess the estimated Risk Ratios (RRs) for acute exacerbations (AE)-IPF in relation to exposure to every 10 μg/m3 increment in air pollutant concentrations, including O3, NO2, PM10, and PM2.5. The meta-analysis revealed a significant association between the increased risk of AE-IPF in PM2.5, yielding RR 1.94 (95% CI 1.30–2.90; p = 0.001). Findings across all the included studies suggest that increased exposure to air pollutants may be linked to a range of health issues in individuals with ILDs.ConclusionA scarcity of available studies on the air pollutants and ILD relationship underscores the imperative for further comprehensive research in this domain. The available data suggest that reducing levels of PM2.5 in the atmosphere could potentially reduce AE frequency and severity in ILD patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The impact of air pollution on interstitial lung disease: a systematic review and meta-analysis

Lan,

Fermoyle,

Troy

et al. 2024

Front. Med.

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“…Most of the changes corresponded to hypomethylation (68.93%), 50.36% of them were present in promoter regions of genes that are mostly linked to respiratory insufficiency, pneumonia, fibrosis, lung cancer, and other diseases ( Shi et al, 2019 ). In peripheral blood samples of patients with Idiopathic Pulmonary Fibrosis (IPF), Goobie et al described that increased long-term PM 2.5 exposure correlated with higher global DNA methylation ( Goobie et al, 2023 ). In another genome-wide study Huang et al further evaluated how different concentrations and durations (single or repeated doses) of PM 2.5 exposure differentially affect both the BEAS-2B transcriptome and DNA methylome ( Huang et al, 2021 ).…”

Section: Pm-induced Dna and Histone Modifications Within The Context ...mentioning

confidence: 99%

Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health

Gavito-Covarrubias,

Ramírez-Díaz,

Guzmán-Linares

et al. 2024

Front. Genet.

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Environmental pollution nowadays has not only a direct correlation with human health changes but a direct social impact. Epidemiological studies have evidenced the increased damage to human health on a daily basis because of damage to the ecological niche. Rapid urban growth and industrialized societies importantly compromise air quality, which can be assessed by a notable accumulation of air pollutants in both the gas and the particle phases. Of them, particulate matter (PM) represents a highly complex mixture of organic and inorganic compounds of the most variable size, composition, and origin. PM being one of the most complex environmental pollutants, its accumulation also varies in a temporal and spatial manner, which challenges current analytical techniques used to investigate PM interactions. Nevertheless, the characterization of the chemical composition of PM is a reliable indicator of the composition of the atmosphere, the quality of breathed air in urbanized societies, industrial zones and consequently gives support for pertinent measures to avoid serious health damage. Epigenomic damage is one of the most promising biological mechanisms of air pollution-derived carcinogenesis. Therefore, this review aims to highlight the implication of PM exposure in diverse molecular mechanisms driving human diseases by altered epigenetic regulation. The presented findings in the context of pan-organic cancer, fibrosis, neurodegeneration and metabolic diseases may provide valuable insights into the toxicity effects of PM components at the epigenomic level and may serve as biomarkers of early detection for novel targeted therapies.

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Disease types and pathogenic mechanisms induced by PM2.5 in five human systems: An analysis using omics and human disease databases

Zhang,

Li,

Zhang

et al. 2024

Environment International

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PM2.5 and constituent component impacts on global DNA methylation in patients with idiopathic pulmonary fibrosis

Cited by 7 publications

References 47 publications

The impact of air pollution on interstitial lung disease: a systematic review and meta-analysis

The impact of air pollution on interstitial lung disease: a systematic review and meta-analysis

Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health

Disease types and pathogenic mechanisms induced by PM2.5 in five human systems: An analysis using omics and human disease databases

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