PLZF regulates Pbx1 transcription and Pbx1–HoxC8 complex leads to androgen-independent prostate cancer proliferation

Kikugawa, Tadahiko; Kinugasa, Yumi; Shiraishi, Ken; Nanba, Daisuke; Nakashiro, Koh‐ichi; Tanji, Nozomu; Yokoyama, Masayoshi; Higashiyama, Shigeki

doi:10.1002/pros.20443

Cited by 44 publications

(37 citation statements)

References 32 publications

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“…1). These results are similar to those of previous studies that identified an involvement of PLZF in the oncogenic transformation of prostate (31), colon (32) and leukemic cells (6). …”

Section: Resultssupporting

confidence: 92%

Promyelocytic leukemia zinc finger triggers ATP‑binding cassette subfamily E member 1‑mediated growth inhibition in breast cancer cells

Suliman

Al-Yahya

2018

Oncol Lett

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The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor that is involved in a number of biological processes, including those regulating cellular growth; however, little is known regarding how it achieves its inhibitory effect in different cell and tissue types. It has previously been demonstrated that PLZF expression levels become diminished during the oncogenic transformation of certain tissue types and thus, may serve as a hallmark for tumor aggressiveness. To examine this in breast cancer, survival curves from available oncology databases were analyzed and demonstrated that PLZF expression was positively associated with increased survival in patients with breast cancer. The mRNA and protein levels of PLZF were also revealed to be associated with the tumorigenicity of four breast cancer cell lines. Since ATP-binding cassette subfamily E member 1 (ABCE1), also known as RNase L inhibitor, has been determined to be a target gene of PLZF, the present study also investigated whether the tumor suppressive effect of PLZF was associated with ABCE1 expression. PLZF was revealed to downregulate the expression of ABCE1 in vitro, which relieved the inhibitory effect of ABCE1 on the ribonuclease L enzyme. Finally, it was concluded that PLZF expression caused an ABCE1-mediated increase in cellular cytotoxicity, as demonstrated by a reduction in the proliferation rate of breast cancer cell lines. The results of the present study are important for understanding how PLZF exerts its final inhibitory actions in breast cancer cells, and potentially in other solid tumors, through the modulation of immunological pathways.

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“…1). These results are similar to those of previous studies that identified an involvement of PLZF in the oncogenic transformation of prostate (31), colon (32) and leukemic cells (6). …”

Section: Resultssupporting

confidence: 92%

Promyelocytic leukemia zinc finger triggers ATP‑binding cassette subfamily E member 1‑mediated growth inhibition in breast cancer cells

Suliman

Al-Yahya

2018

Oncol Lett

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“…Analysis of PLZF knock-out mice revealed that the protein is a growth inhibitory and proapoptotic factor in the limb bud in vivo [35]. Interestingly, treatment with cannabinoids or overexpression of PLZF inhibits growth of prostate cancer cells [36][37][38]. Together with our results, these findings imply that the action of CB is mediated by the Go/i::PLZF signaling pathway to inhibit cell growth.…”

Section: Discussionsupporting

confidence: 77%

The alpha subunit of Go interacts with promyelocytic leukemia zinc finger protein and modulates its functions

Won¹,

Park²,

Ju³

et al. 2008

Cellular Signalling

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“…Although the role of HOXs in cancer is not fully understood, its aberrant expression is thought to affect pathways that promote tumorigenesis and metastasis (27). For instance, HOXC8 mRNA is overexpressed in prostate cancer cells and is associated with tumor cell proliferation and metastasis (28)(29)(30). In addition, HOXC5 and HOXC8 mRNAs are upregulated in cervical cancer cells (31), and one recent study suggested HOXC10 plays a key role of in the progression and invasion in cervical cancer (32).…”

Section: Discussionmentioning

confidence: 99%

Upregulation of miR-196a andHOTAIRDrive Malignant Character in Gastrointestinal Stromal Tumors

et al. 2012

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Large intergenic noncoding RNAs (lincRNA) have been less studied than miRNAs in cancer, although both offer considerable theranostic potential. In this study, we identified frequent upregulation of miR-196a and lincRNA HOTAIR in high-risk gastrointestinal stromal tumors (GIST). Overexpression of miR-196a was associated with high-risk grade, metastasis and poor survival among GIST specimens. miR-196a genes are located within the HOX gene clusters and microarray expression analysis revealed that the HOXC and HOTAIR gene were also coordinately upregulated in GISTs which overexpress miR-196a. In like manner, overexpression of HOTAIR was also strongly associated with high-risk grade and metastasis among GIST specimens. RNA interference-mediated knockdown of HOTAIR altered the expression of reported HOTAIR target genes and suppressed GIST cell invasiveness. These findings reveal concurrent overexpression of HOX genes with noncoding RNAs in human cancer in this setting, revealing miR-196a and HOTAIR as potentially useful biomarkers and therapeutic targets in malignant GISTs.

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PLZF regulates Pbx1 transcription and Pbx1–HoxC8 complex leads to androgen-independent prostate cancer proliferation

Abstract: Androgen-independent cell line DU145 cells lack PLZF gene expression, resulting in the upregulation of Pbx1 and HoxC8 expression. The Pbx1-HoxC8 heterocomplex may lead to androgen-independent growth in prostate cancer.

Cited by 44 publications

References 32 publications

Promyelocytic leukemia zinc finger triggers ATP‑binding cassette subfamily E member 1‑mediated growth inhibition in breast cancer cells

Promyelocytic leukemia zinc finger triggers ATP‑binding cassette subfamily E member 1‑mediated growth inhibition in breast cancer cells

The alpha subunit of Go interacts with promyelocytic leukemia zinc finger protein and modulates its functions

Upregulation of miR-196a andHOTAIRDrive Malignant Character in Gastrointestinal Stromal Tumors

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