Pluronic stabilized Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles for intracellular delivery of curcumin

Barick, K. C.; Ekta, .; Gawali, Santosh L.; Sarkar, Avipsha; Kunwar, Amit; Priyadarsini, K. Indira; Hassan, P. A.

doi:10.1039/c6ra21207g

Cited by 42 publications

(23 citation statements)

References 36 publications

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“…In the DRIFT spectrum of assyn-MgFe 2 O 4 @phe-PMO (Fig. 7, black) the presence of Pluronic P123® template molecules is obvious due to the intense vibration bands at 2874-2935 and 2972 cm −1 and C-H stretching and bending vibrations in the range between 1500 and 1350 cm −1 [75][76][77][78][79]. The other vibration bands derived from the phe-PMO network [80,81] and the broad spectral feature around 3380 cm −1 are due to adsorbed water molecules on the surface.…”

Section: Resultsmentioning

confidence: 99%

Stabilization of nanosized MgFe2O4 nanoparticles in phenylene-bridged KIT-6-type ordered mesoporous organosilica (PMO)

Timm

Bloesser

Zhang

et al. 2020

Microporous and Mesoporous Materials

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The unique combination of two functional materials, namely the earth-abundant spinel magnesioferrite (MgFe 2 O 4) and mesoporous phenylene-bridged KIT-6-type organosilica, was developed. The mesoporous organosilica acts as host matrix for the nanosized MgFe 2 O 4 particles which leads to better dispersibility and increased stability towards acids. Additionally, the mesoporous host is a very good material to generate a toolbox towards applicable materials due to flexible functionalization. Nanosized, monodisperse MgFe 2 O 4 crystallites were synthesized via a facile microwave assisted non-aqueous reaction path. Afterwards, the particles were embedded in phenylene-bridged periodic mesoporous organosilica with 3D cubic pore arrangement (KIT-6-type PMO) generating a new kind of mesoporous inorganic-organic hybrid material (MgFe 2 O 4 @phe-PMO). The MgFe 2 O 4 @phe-PMO exhibits the characteristics of both components: A high specific surface area of 1164 m 2 g-1 with clearly defined and highly ordered micro-and mesopores (1.5 and 6.8 nm), and the broad absorption of visible and UV light due to the phenylene bridging units in the PMO and the MgFe 2 O 4 particles. The presence of MgFe 2 O 4 nanoparticles in the PMO matrix is proven by UV/Vis spectroscopy, powder X-ray diffraction (PXRD) and transmission electron microscopy (TEM). Selected area electron diffraction (SAED) and Scanning TEM in atomic resolution was chosen to demonstrate the crystallinity and phase purity of MgFe 2 O 4 particles in the hybrid material. An additional focus was laid on calcination of the MgFe 2 O 4 /PMO hybrids to remove template molecules, while preventing rearrangement or shrinkage of the pore system and to promote further crystallization of the MgFe 2 O 4 nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Stabilization of nanosized MgFe2O4 nanoparticles in phenylene-bridged KIT-6-type ordered mesoporous organosilica (PMO)

Timm

Bloesser

Zhang

et al. 2020

Microporous and Mesoporous Materials

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“…This copolymer was widely used as a stabilizing agent for nanoparticles surface modification in various biomedical applications. 12 Moreover, Pluronic F-127 was found to be the most efficient copolymer for colloidal stabilization among many triblock copolymers in previous studies. 13,14 Furthermore, the unique thermo-reversible micellization characteristic of Pluronic F-127 around body temperature makes it desirable for drug delivery, controlled release, gene therapy, and tissue engineering.…”

Section: Introductionmentioning

confidence: 93%

“…Hence, the adsorption of Pluronic F-127 on the surface of ZnO NPs provides the site of encapsulation without altering the composition of ZnO NPs. 12…”

Section: X-ray Crystallographic Analysismentioning

confidence: 99%

Novel Pluronic F‐127‐coated ZnO nanoparticles: Synthesis, characterization, and their in‐vitro cytotoxicity evaluation

Abuelsamen

Mahmud

Kaus

et al. 2021

Polymers for Advanced Techs

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Zinc oxide (ZnO) nanoparticles (NPs) are increasingly recognized for their potential use in various biomedical applications. However, the tendency of bare ZnO NPs to aggregate and their poor stability in the biological environment reduce their biocompatibility and lead to cytotoxicity in normal healthy cells. This study attempted to avoid this by synthesizing a novel Pluronic F-127-coated ZnO NPs and evaluating their cytotoxicity impact on normal healthy human endothelial AE.hy296 cells. The characterization results revealed that Pluronic coating process remarkably enhanced the stability of ZnO NPs and did not alter their desired crystalline structure. The cytotoxicity of bare and Pluronic F-127-coated ZnO NPs were evaluated through MTT assay and microscopy imaging. The results of the cytotoxicity tests showed that Pluronic F-127 modification significantly improved the biocompatibility and reduced the cytotoxicity of ZnO NPs toward the normal endothelial human EA.hy926 cells.Based on their high crystallinity, stability, and biocompatibility, Pluronic F-123-coated ZnO NPs hold promising potential for miscellaneous biomedical applications.

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“…F127 was selected because it is a kind of biocompatible copolymer, whose hydrophobic segment can encapsulate drugs or uorophores and hydrophilic segment can provide the water-soluble properties. [15][16][17] Compared with dextran or other polymer, the drug can be loaded by physical encapsulation because of its self-assemble behavior while using F127 coated Fe 3 O 4 nanoparticles. Some similar system has been reported for drug delivery and MR diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Folic acid modified Fe₃O₄ nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging

et al. 2020

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Pluronic stabilized Fe₃O₄ magnetic nanoparticles for intracellular delivery of curcumin

Abstract: Water-dispersible Pluronic stabilized Fe3O4 magnetic nanoparticles were developed for intracellular delivery of hydrophobic anticancer drug.

Cited by 42 publications

References 36 publications

Stabilization of nanosized MgFe2O4 nanoparticles in phenylene-bridged KIT-6-type ordered mesoporous organosilica (PMO)

Stabilization of nanosized MgFe2O4 nanoparticles in phenylene-bridged KIT-6-type ordered mesoporous organosilica (PMO)

Novel Pluronic F‐127‐coated ZnO nanoparticles: Synthesis, characterization, and their in‐vitro cytotoxicity evaluation

Folic acid modified Fe₃O₄ nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging

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Pluronic stabilized Fe3O4 magnetic nanoparticles for intracellular delivery of curcumin

Abstract: Water-dispersible Pluronic stabilized Fe3O4 magnetic nanoparticles were developed for intracellular delivery of hydrophobic anticancer drug.

Cited by 42 publications

References 36 publications

Stabilization of nanosized MgFe2O4 nanoparticles in phenylene-bridged KIT-6-type ordered mesoporous organosilica (PMO)

Stabilization of nanosized MgFe2O4 nanoparticles in phenylene-bridged KIT-6-type ordered mesoporous organosilica (PMO)

Novel Pluronic F‐127‐coated ZnO nanoparticles: Synthesis, characterization, and their in‐vitro cytotoxicity evaluation

Folic acid modified Fe3O4 nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging

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Product

Resources

About

Pluronic stabilized Fe₃O₄ magnetic nanoparticles for intracellular delivery of curcumin

Folic acid modified Fe₃O₄ nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging