Pluronic® F127-based systemic vaccine delivery systems

Effect of aluminum hydroxide adjuvant and formaldehyde in the formulation of rPA anthrax vaccine

“…Various formulations have been tested in preparing anthrax vaccines based upon rPA for its ability to elicit optimal immunological responses. Recent examples include Toll-like receptor ligands CpG ODN and Resiquimod R-848 [35,36], pluronic F127, a non-ionic, hydrophilic polyoxyethylenepolyoxypropylene block copolymer [37], additional vaccine antigens such as capsule [38] or EF [39,40], DNA vaccines [41], and mucosal vaccine strategies [42,43]. That antibodies have been recognized as important in protection is demonstrated by the number of immunotherapeutic reagents that have been recently suggested [44][45][46][47][48][49].…”

Alternative administration routes and delivery technologies for polio vaccines

“…They compared the IM administration with sublingual administration using a thermoresponsive gel (TRG) delivery system. These TRG systems are liquid at room temperatures and become solid in warmer environments, like the mouth [63,64]. The solid gel has high mucosal adhesion properties and ensures slow release and potentially minimal loss because of swallowing.…”

Synthesis and Characterization of Stimuli Responsive Block Copolymers, Self-Assembly Behavior and Applications

“…The dynamic mechanical analysis measurements were used to monitor the elastic modulus of the gel as a function of temperature. The elastic modulus of the pentablock copolymer gel (22.5 wt % copolymer), with and without lysozyme, is shown in The effects of electrolytes [36,37], pharmaceutically acceptable organic solvents [23] and polysaccharides [12,38] proteins [29], and mammalian cell-culture media [39], on reducing the sol-gel transition temperature of aqueous Pluronic® copolymer solutions have been reported previously. Because the mechanism for the thermoreversible gelation of the pentablock copolymer solution is essentially the same as that of Pluronic® F127 solutions, it was anticipated that the sol-gel transition temperature would be effected by the high concentration of the lysozyme.…”