Pluronic-based nanovehicles: Recent advances in anticancer therapeutic applications

Jarak, Ivana; Varela, Carla; Silva, E. J. Tavares da; Roleira, Fernanda M.F.; Veiga, Francisco; Figueiras, Ana

doi:10.1016/j.ejmech.2020.112526

Cited by 50 publications

(38 citation statements)

References 198 publications

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“…It is known that POE-PPO-POE copolymers are non-degradable; however, molecules with a molecular weight of 15 kDa or less are usually filtered by the kidney and cleared in urine [282]. On the other hand, in recent publications, the complement system activation by POE-containing polymers has been analyzed [283,284]. Authors suggested that these polymers could trigger acute hypersensitivity reactions or pseudoallergic reactions [283].…”

Section: Advantages and Disadvantagesmentioning

confidence: 99%

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

et al. 2021

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Surfactants are essential in the manufacture of polymeric nanoparticles by emulsion formation methods and to preserve the stability of carriers in liquid media. The deposition of non-ionic surfactants at the interface allows a considerable reduction of the globule of the emulsion with high biocompatibility and the possibility of oscillating the final sizes in a wide nanometric range. Therefore, this review presents an analysis of the three principal non-ionic surfactants utilized in the manufacture of polymeric nanoparticles; polysorbates, poly(vinyl alcohol), and poloxamers. We included a section on general properties and uses and a comprehensive compilation of formulations with each principal non-ionic surfactant. Then, we highlight a section on the interaction of non-ionic surfactants with biological barriers to emphasize that the function of surfactants is not limited to stabilizing the dispersion of nanoparticles and has a broad impact on pharmacokinetics. Finally, the last section corresponds to a recommendation in the experimental approach for choosing a surfactant applying the systematic methodology of Quality by Design.

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Section: Advantages and Disadvantagesmentioning

confidence: 99%

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

et al. 2021

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“…The poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer (PEO-PPO-PEO) (commercially available as Pluronics and Poloxamers) is an amphiphilic block copolymer that can self-assembly into micelles in aqueous solution. Enormous study shown that the micellular structure is a practical approach for incorporating medicines, as it not only builds a drug delivery system but also applies to gene and cancer therapies [ 5 , 6 , 7 , 8 , 9 , 10 ]. The key attribute for the biological activity of Pluronic block copolymers is their ability to interact with multidrug-resistant cancer tumors with respect to various anticancer agents both in vitro and in vivo [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Lin

Yeh

2021

Polymers

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Chemotherapy is one of the most important ways to treat cancer. At present, chemotherapy medicines are mainly administered by intravenous injection or oral administration. However, systemic medical care requires the dosage of high concentrations of drugs to defeat the malignant tumor growth. In recent years, the use of polymer composites for local and sustained drug release has become an important field of research to minimize side effects due to high-concentration chemotherapy drugs. Here, 19F-{1H} heteronuclear Overhauser enhancement spectroscopy (HOESY) was used to study the micellular environment of the F-containing chemotherapeutic drug 5-FU in Pluronic F127, Pluronic L121, and F127/L121 binary blending composites. The distribution of 5-FU in micelles is related to the PEO and PPO segment length of Pluronic polymers and the environmental temperature. The drug release tests further confirm that if 5-FU medicines were loaded in the PPO segment inside the micelles, the purpose of the prolonged drug release carrier is achieved.

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“…However, they readily dissolve in the presence of appropriate amounts (>1 mg mL −1 ) of Pluronic 123 and retain their photophysical properties as long as their concentration is maintained in the micromolar regime (<50 μM) to avoid aggregation. Indeed, this particular amphiphilic polymer is known to form micelles capable of capturing hydrophobic molecules in their interior and solubilizing them in aqueous environments (Pitto-Barry and Barry, 2015;Jarak et al, 2020). Consistently, DLS measurements on the resulting solutions indicate the formation of nanoparticles with an average hydrodynamic diameter of ca.…”

Section: Resultsmentioning

confidence: 72%

Switchable Coumarins for Ratiometric pH Sensing

et al. 2021

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A fluorescent chromophore and a pH-sensitive heterocycle were integrated within a single covalent skeleton to generate four molecular switches with ratiometric fluorescence response. Upon acidification, the pH-sensitive heterocycle opens to shift bathochromically the absorption and emission bands of the fluorescent chromophore. As a result, an equilibrium between two species with resolved fluorescence is established with fast kinetics in aqueous environments. The relative amounts of the two interconverting forms and their relative emission intensities change with pH, providing the opportunity to probe this parameter ratiometrically with fluorescence measurements. Specifically, the resolved emissions of the two species can be collected in separate detection channels of the same microscope to map their ratio across a labeled sample and reconstruct its pH distribution ratiometrically with spatial resolution at the micrometer level. Additionally, the sensitivity of these molecular switches varies with the nature of the heterocyclic ring and with its substituents, allowing the possibility of regulating their response to a given pH range of interest with the aid of chemical synthesis. Thus, a family of valuable fluorescent probes for ratiometric pH sensing in a diversity of samples can emerge from the unique combination of structural and photophysical properties designed into our innovative molecular switches.

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Pluronic-based nanovehicles: Recent advances in anticancer therapeutic applications

Cited by 50 publications

References 198 publications

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Switchable Coumarins for Ratiometric pH Sensing

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