Pluripotent very small embryonic-like stem cells co-exist along with spermatogonial stem cells in adult mammalian testis

Bhartiya, Deepa; Anand, Sandhya; Kaushik, Ankita

doi:10.1093/humupd/dmz030

Cited by 8 publications

(1 citation statement)

References 18 publications

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“…As several studies on SSCs have been conducted using whole tissue rather than isolated cells, a short remark shall be added. This concerns the question of whether proliferation in testes is sufficiently described on the basis of SSCs or whether contributions of pluripotent small embryonic-like stem cells exist, which may confound conclusions, as recently discussed [48][49][50].…”

Section: Pluripotent and Unipotent Stem Cells: Distinction Between Pr...mentioning

confidence: 99%

Melatonin and the Programming of Stem Cells

Hardeland

2022

IJMS

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Melatonin interacts with various types of stem cells, in multiple ways that comprise stimulation of proliferation, maintenance of stemness and self-renewal, protection of survival, and programming toward functionally different cell lineages. These various properties are frequently intertwined but may not be always jointly present. Melatonin typically stimulates proliferation and transition to the mature cell type. For all sufficiently studied stem or progenitor cells, melatonin’s signaling pathways leading to expression of respective morphogenetic factors are discussed. The focus of this article will be laid on the aspect of programming, particularly in pluripotent cells. This is especially but not exclusively the case in neural stem cells (NSCs) and mesenchymal stem cells (MSCs). Concerning developmental bifurcations, decisions are not exclusively made by melatonin alone. In MSCs, melatonin promotes adipogenesis in a Wnt (Wingless-Integration-1)-independent mode, but chondrogenesis and osteogenesis Wnt-dependently. Melatonin upregulates Wnt, but not in the adipogenic lineage. This decision seems to depend on microenvironment and epigenetic memory. The decision for chondrogenesis instead of osteogenesis, both being Wnt-dependent, seems to involve fibroblast growth factor receptor 3. Stem cell-specific differences in melatonin and Wnt receptors, and contributions of transcription factors and noncoding RNAs are outlined, as well as possibilities and the medical importance of re-programming for transdifferentiation.

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Section: Pluripotent and Unipotent Stem Cells: Distinction Between Pr...mentioning

confidence: 99%