Pluripotent Stem Cells for Cell Therapy

Schroeder, Insa S.

doi:10.1007/978-1-0716-1225-5_2

Cited by 1 publication

(1 citation statement)

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“…On the other hand, hiPSCs are emerging as promising candidates for regenerative medicine applications [ 28 , 29 , 30 , 31 , 32 ]. Both hESCs and hiPSCs can differentiate into any somatic cell type, including neurons, pancreatic cells, hepatocytes, and functional cardiomyocytes [ 33 ], and therefore can be used in cell-based therapies, especially for organs, such as the heart, which lack regenerative capabilities [ 34 , 35 , 36 , 37 ]. Additionally, autologous stem cell therapy is made possible by the availability of patient-derived hiPSCs, thereby overriding the problems associated with immune rejection [ 35 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Preclinical Large Animal Porcine Models for Cardiac Regeneration and Its Clinical Translation: Role of hiPSC-Derived Cardiomyocytes

Sridharan

Pracha

Rana

et al. 2023

Cells

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Myocardial Infarction (MI) occurs due to a blockage in the coronary artery resulting in ischemia and necrosis of cardiomyocytes in the left ventricular heart muscle. The dying cardiac tissue is replaced with fibrous scar tissue, causing a decrease in myocardial contractility and thus affecting the functional capacity of the myocardium. Treatments, such as stent placements, cardiac bypasses, or transplants are beneficial but with many limitations, and may decrease the overall life expectancy due to related complications. In recent years, with the advent of human induced pluripotent stem cells (hiPSCs), newer avenues using cell-based approaches for the treatment of MI have emerged as a potential for cardiac regeneration. While hiPSCs and their derived differentiated cells are promising candidates, their translatability for clinical applications has been hindered due to poor preclinical reproducibility. Various preclinical animal models for MI, ranging from mice to non-human primates, have been adopted in cardiovascular research to mimic MI in humans. Therefore, a comprehensive literature review was essential to elucidate the factors affecting the reproducibility and translatability of large animal models. In this review article, we have discussed different animal models available for studying stem-cell transplantation in cardiovascular applications, mainly focusing on the highly translatable porcine MI model.

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