Plummer-Vinson syndrome

Phatak, Sanat; Redkar, Neelam; Patil, Meenakshi Amit; Kuwar, Ajay

doi:10.1136/bcr-2012-006403

Cited by 6 publications

(7 citation statements)

References 2 publications

(1 reference statement)

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“…PVS is a rare disease characterized by three characteristics: intermittent dysphagia, iron‐deficiency anemia, and esophageal webs. It is a rare syndrome, but the diagnosis is important since the disorder constitutes a risk factor for cancer of the upper gastrointestinal tract (Phatak et al., 2012). In the present study, the individual with PVS was a 27‐year‐old woman and the disorder was diagnosed after oral mucosa pigmentation.…”

Section: Discussionmentioning

confidence: 99%

Oral pigmented lesions in syndromic individuals: A systematic review

et al. 2021

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Objective: To systematically integrate the available data published in the literature on oral pigmented lesions (OPL) associated with syndromes, summarizing the clinical and demographic features of the individuals. Materials and Methods:An electronic search was undertaken in six databases.Eligibility criteria were articles in English, Spanish, and Portuguese describing case reports or case series of OPL associated with syndromes. Data were aggregated and statistically evaluated. Results: About 108 articles reporting 149 cases of individuals with syndromes were identified. Among the affected individuals, nine syndromes were reported. The mean age at diagnosis was 35.93 years (0.41 to 83 years), with a predilection for white (n = 85/85.86%) female (n = 102/68.46%) individuals. As regards the number of lesions, 109 (73.15%) were multiple and 40 (26.85%) were single. Lip represented the anatomical location more affected (122 cases/38.01%), followed by the buccal mucosa (100 cases/31.15%). Brownish lesions accounted for 82 (69.49%) cases. The mean time of evolution was 10.52 years (0.16 to 56 years). OPL preceding diagnosis of the syndrome was observed in 111 (74.50%) cases. Conclusions: Although these syndromes are uncommon, dentists should be able to recognize their manifestations, since oral manifestations can represent an important aspect in early diagnosis.

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Section: Discussionmentioning

confidence: 99%

Oral pigmented lesions in syndromic individuals: A systematic review

et al. 2021

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“…Plummer-Vinson syndrome (PVS), also known as Patterson-Kelly syndrome, presents with the classic triad of iron-deficiency anemia, dysphagia, and esophageal webs [ 1 ]. Other common findings in PVS include glossitis, koilonychia, and enlargement of the spleen and thyroid.…”

Section: Introductionmentioning

confidence: 99%

“…Iron-deficiency anemia is the most important risk factor; however, other risk factors include malnutrition, autoimmune diseases, or genetic predisposition [ 2 ]. The pathogenesis of this extremely rare condition is unclear; however, iron deficiency plays a key role, and it is hypothesized that depletion of iron-dependent oxidative enzymes causes myasthenic changes in swallowing muscles, esophageal mucosal atrophy, and formation of esophageal webs [ 1 ]. The best initial imaging study is the barium esophagogram [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of this extremely rare condition is unclear; however, iron deficiency plays a key role, and it is hypothesized that depletion of iron-dependent oxidative enzymes causes myasthenic changes in swallowing muscles, esophageal mucosal atrophy, and formation of esophageal webs [ 1 ]. The best initial imaging study is the barium esophagogram [ 1 ]. Esophagogastroduodenoscopy (EGD) can also be done in order to visualize the esophageal web and perform esophageal web dilation.…”

Section: Introductionmentioning

confidence: 99%

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Plummer-Vinson Syndrome in an African-American Woman

Patel

Kassir

Patel

et al. 2021

Case Rep Gastroenterol

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Plummer-Vinson syndrome (PVS) presents with the classic triad of iron-deficiency anemia, dysphagia, and esophageal webs. The mainstay treatment of PVS is iron supplementation and the dysphagia usually responds to iron supplementation before the hematologic abnormalities are corrected. This syndrome classically affects middle-aged Caucasian women and very few cases have been reported in African Americans. We present a rare case of PVS in an African-American woman. A 63-year-old woman presented with shortness of breath, dysphagia, and lightheadedness for several weeks. Chest X-ray was negative for any acute abnormalities. Initial hemoglobin was 7.0 g/dL, which improved to 7.5 g/dL after 1 unit of packed red blood cells. She had a mean corpuscular volume of 62 fL, a ferritin level of 6 ng/mL, and an iron level of 12 μg/dL. Fecal occult blood test was negative and barium swallow revealed a proximal esophageal web. Her dysphagia did not significantly improve despite intravenous iron supplementation and esophageal web dilation. Video-fluoroscopic swallow study revealed esophageal and pharyngeal phase dysphagia with food entrapment. She was discharged with plans to follow up with a primary care physician and repeat esophagogastroduodenoscopy in 1 year. This case report highlights a rare case of PVS in an African-American woman and emphasizes the importance of maintaining a comprehensive and broad differential diagnosis.

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“…It has been proposed that barium swallow was more cost effective than upper endoscopy for diagnosis of abnormal esophageal motility, and in contrast, initial endoscopy with therapeutic intent was less costly for patients suspected with history suggesting benign obstruction [21]. On the other hand, webs associated with PVS may resolve spontaneously with iron supplementation therapy, obviating majority of endoscopic interventions [22]. Barium esophagograms are likely to provide a better roadmap prior to therapeutic interventions.…”

mentioning

confidence: 99%

"Plummer -Vinson Syndrome: Diagnosis by Barium Esophagogram Studies May Still Be Important in the Shortage of Endoscopic Sources"

Ergelen

2021

BJSTR

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Plummer-Vinson syndrome

Cited by 6 publications

References 2 publications

Oral pigmented lesions in syndromic individuals: A systematic review

Oral pigmented lesions in syndromic individuals: A systematic review

Plummer-Vinson Syndrome in an African-American Woman

"Plummer -Vinson Syndrome: Diagnosis by Barium Esophagogram Studies May Still Be Important in the Shortage of Endoscopic Sources"

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