PLTP activity decreases with weight loss

Murdoch, Susan J.; Kahn, Steven E.; Albers, John J.; Brunzell, John D.; Purnell, Jonathan Q.

doi:10.1194/jlr.m300073-jlr200

Cited by 33 publications

(16 citation statements)

References 42 publications

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“…PLTP is a lipid transfer protein that belongs to the lipopolysaccharide family. Previous reports revealed that plasma PLTP activity is elevated in type 2 diabetes mellitus, and obesity, with a decrease in PLTP being observed after weight loss 67-68. Higher PLTP activity could contribute to elevated cardiovascular risk in the presence of obesity and insulin resistance 69.…”

Section: Discussionmentioning

confidence: 97%

Quantitative Genomics of 30 Complex Phenotypes in Wagyu x Angus F₁ Progeny

Zhang¹,

Michal²,

O’Fallon³

et al. 2012

Int. J. Biol. Sci.

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In the present study, a total of 91 genes involved in various pathways were investigated for their associations with six carcass traits and twenty-four fatty acid composition phenotypes in a Wagyu×Angus reference population, including 43 Wagyu bulls and their potential 791 F1 progeny. Of the 182 SNPs evaluated, 102 SNPs that were in Hardy-Weinberg equilibrium with minor allele frequencies (MAF>0.15) were selected for parentage assignment and association studies with these quantitative traits. The parentage assignment revealed that 40 of 43 Wagyu sires produced over 96.71% of the calves in the population. Linkage disequilibrium analysis identified 75 of 102 SNPs derived from 54 genes as tagged SNPs. After Bonferroni correction, single-marker analysis revealed a total of 113 significant associations between 44 genes and 29 phenotypes (adjusted P<0.05). Multiple-marker analysis confirmed single-gene associations for 10 traits, but revealed two-gene networks for 9 traits and three-gene networks for 8 traits. Particularly, we observed that TNF (tumor necrosis factor) gene is significantly associated with both beef marbling score (P=0.0016) and palmitic acid (C16:0) (P=0.0043), RCAN1 (regulator of calcineurin 1) with rib-eye area (P=0.0103), ASB3 (ankyrin repeat and SOCS box-containing 3) with backfat (P=0.0392), ABCA1 (ATP-binding cassette A1) with both palmitic acid (C16:0) (P=0.0025) and oleic acid (C18:1n9) (P=0.0114), SLC27A1(solute carrier family 27 A1) with oleic acid (C18:1n9) (P=0.0155), CRH (corticotropin releasing hormone) with both linolenic acid (OMEGA-3) (P=0.0200) and OMEGA 6:3 RATIO (P=0.0054), SLC27A2 (solute carrier family 27 A2) with both linoleic acid (OMEGA-6) (P=0.0121) and FAT (P=0.0333), GNG3 (guanine nucleotide binding protein gamma 3 with desaturase 9 (P=0.0115), and EFEMP1 (EGF containing fibulin-like extracellular matrix protein 1), PLTP (phospholipid transfer protein) and DSEL (dermatan sulfate epimerase-like) with conjugated linoleic acid (P=0.0042-0.0044), respectively, in the Wagyu x Angus F1 population. In addition, we observed an interesting phenomenon that crossbreeding of different breeds might change gene actions to dominant and overdominant modes, thus explaining the origin of heterosis. The present study confirmed that these important families or pathway-based genes are useful targets for improving meat quality traits and healthful beef products in cattle.

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Section: Discussionmentioning

confidence: 97%

Quantitative Genomics of 30 Complex Phenotypes in Wagyu x Angus F₁ Progeny

Zhang¹,

Michal²,

O’Fallon³

et al. 2012

Int. J. Biol. Sci.

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“…Plasma PLTP activity is elevated in patients suffering from diabetes mellitus type 1 [34] and type 2 [35], [36]. In addition, increased PLTP is found in obese individuals [37]–[40] while it is decreased with weight loss [41]. The elevated plasma PLTP activity in patients with type 2 diabetes mellitus is positively correlated with the carotid intima-media thickness [42].…”

Section: Discussionmentioning

confidence: 99%

Elevated Expression of Phospholipid Transfer Protein in Bone Marrow Derived Cells Causes Atherosclerosis

et al. 2008

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BackgroundPhospholipid transfer protein (PLTP) is expressed by various cell types. In plasma, it is associated with high density lipoproteins (HDL). Elevated levels of PLTP in transgenic mice result in decreased HDL and increased atherosclerosis. PLTP is present in human atherosclerotic lesions, where it seems to be macrophage derived. The aim of the present study is to evaluate the atherogenic potential of macrophage derived PLTP.Methods and FindingsHere we show that macrophages from human PLTP transgenic mice secrete active PLTP. Subsequently, we performed bone marrow transplantations using either wild type mice (PLTPwt/wt), hemizygous PLTP transgenic mice (huPLTPtg/wt) or homozygous PLTP transgenic mice (huPLTPtg/tg) as donors and low density lipoprotein receptor deficient mice (LDLR−/−) as acceptors, in order to establish the role of PLTP expressed by bone marrow derived cells in diet-induced atherogenesis. Atherosclerosis was increased in the huPLTPtg/wt→LDLR−/− mice (2.3-fold) and even further in the huPLTPtg/tg→LDLR−/− mice (4.5-fold) compared with the control PLTPwt/wt→LDLR−/− mice (both P<0.001). Plasma PLTP activity levels and non-HDL cholesterol were increased and HDL cholesterol decreased compared with controls (all P<0.01). PLTP was present in atherosclerotic plaques in the mice as demonstrated by immunohistochemistry and appears to co-localize with macrophages. Isolated macrophages from PLTP transgenic mice do not show differences in cholesterol efflux or in cytokine production. Lipopolysaccharide activation of macrophages results in increased production of PLTP. This effect was strongly amplified in PLTP transgenic macrophages.ConclusionsWe conclude that PLTP expression by bone marrow derived cells results in atherogenic effects on plasma lipids, increased PLTP activity, high local PLTP protein levels in the atherosclerotic lesions and increased atherosclerotic lesion size.

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“…PLTP activity in plasma appears to be strongly influenced by body weight, in particular with subcutaneous fat [56, 157, 158]. However, the impact of insulin resistance on plasma PLTP activity in non-diabetic humans is unclear [157, 158].…”

Section: Pltp In Human Diseasesmentioning

confidence: 99%

“…However, the impact of insulin resistance on plasma PLTP activity in non-diabetic humans is unclear [157, 158]. In patients with diabetes, PLTP activity in plasma is significantly increased compared to healthy controls.…”

Section: Pltp In Human Diseasesmentioning

confidence: 99%

Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism

Albers

Vuletic

Cheung

2012

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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106

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The understanding of the physiological and pathophysiological role of PLTP has greatly increased since the discovery of PLTP more than a quarter of century ago. A comprehensive review of PLTP is presented on the following topics: PLTP gene organization and structure; PLTP transfer properties; different forms of PLTP; characteristics of plasma PLTP complexes; relationship of plasma PLTP activity, mass and specific activity with lipoprotein and metabolic factors; role of PLTP in lipoprotein metabolism; PLTP and reverse cholesterol transport; insights from studies of PLTP variants; insights of PLTP from animal studies; PLTP and atherosclerosis; PLTP and signal transduction; PLTP in the brain; and PLTP in human disease. PLTP's central role in lipoprotein metabolism and lipid transport in the vascular compartment has been firmly established. However, more studies are needed to further delineate PLTP's functions in specific tissues, such as the lung, brain and adipose tissue. Furthermore, the specific role that PLTP plays in human diseases, such as atherosclerosis, cancer, or neurodegenerative disease, remains to be clarified. Exciting directions for future research include evaluation of PLTP's physiological relevance in intracellular lipid metabolism and signal transduction, which undoubtedly will advance our knowledge of PLTP functions in health and disease.

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PLTP activity decreases with weight loss

Cited by 33 publications

References 42 publications

Quantitative Genomics of 30 Complex Phenotypes in Wagyu x Angus F₁ Progeny

Quantitative Genomics of 30 Complex Phenotypes in Wagyu x Angus F₁ Progeny

Elevated Expression of Phospholipid Transfer Protein in Bone Marrow Derived Cells Causes Atherosclerosis

Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism

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PLTP activity decreases with weight loss

Cited by 33 publications

References 42 publications

Quantitative Genomics of 30 Complex Phenotypes in Wagyu x Angus F1 Progeny

Quantitative Genomics of 30 Complex Phenotypes in Wagyu x Angus F1 Progeny

Elevated Expression of Phospholipid Transfer Protein in Bone Marrow Derived Cells Causes Atherosclerosis

Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism

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Quantitative Genomics of 30 Complex Phenotypes in Wagyu x Angus F₁ Progeny

Quantitative Genomics of 30 Complex Phenotypes in Wagyu x Angus F₁ Progeny