Ploidy as Prognostic Determinant in Pancreatic Cancer

Weger, A.; Graf, Anton-H.; Askensten, U; Schwab, G.; Bodner, Ehud; Auer, Gert; Mikuz, Gregor

doi:10.1016/s0140-6736(87)92600-6

Cited by 15 publications

(1 citation statement)

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“…The DNA index and DNA ploidy status have been reported to serve as prognostic and predictive biomarkers of cancer for many different types of malignant tumors (6-10). Weger et al (11), Porschen et al (12) and Klein et al (13) observed a strong correlation between DNA ploidy status and survival of patients with pancreatic cancer. In a prospective clinical trial, Kamphues et al showed that the DNA index serves as an independent predictive marker in patients with pancreatic head cancer (14).…”

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confidence: 93%

DNA Cytometry for Differentiation Between Low- and Mediumgrade Dysplasia in Intraductal Papillary Mucinous Neoplasms

Klein

Denecke

Faber

et al. 2017

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confidence: 93%

DNA Cytometry for Differentiation Between Low- and Mediumgrade Dysplasia in Intraductal Papillary Mucinous Neoplasms

Klein

Denecke

Faber

et al. 2017

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DNA ploidy analysis of mucinous cystic tumors of the pancreas: Correlation of aneuploidy with malignancy and poor prognosis

Southern

Warshaw

Lewandrowski

1996

Cancer

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Flow cytometric analysis of nuclear DNA content of duct cell carcinoma of the pancreas

Yoshimura

Manabe

Imamura

et al. 1992

Cancer

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Background. This study was designed to evaluate the efficacy of nuclear DNA content analysis in determining the prognosis of carcinoma of the pancreas. Methods. Resected and paraffin‐embedded specimens from 72 patients with duct cell carcinoma of the pancreas were examined, and flow cytometry was used to explore the relationship between DNA ploidy and TNM classification or histologic grade. Results. DNA aneuploidy was found histologically in 42.9%, 56.8%, and 71.4% of Grade 1, 2, and 3 tumors, respectively. DNA ploidy showed a statistically significant correlation with T category and retroperitoneal invasion. The cumulative survival rate of patients with retroperitoneal invasion was shorter than that of those without retroperitoneal invasion. Among the patients with retroperitoneal invasion, those with DNA aneuploidy had a significantly shorter survival time than did those with DNA diploidy. Conclusions. The DNA ploidy pattern, in combination with the presence or absence of retroperitoneal invasion, appears to be useful in predicting the prognosis for duct cell adenocarcinoma of the pancreas.

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Ploidy as Prognostic Determinant in Pancreatic Cancer

Cited by 15 publications

References 0 publications

DNA Cytometry for Differentiation Between Low- and Mediumgrade Dysplasia in Intraductal Papillary Mucinous Neoplasms

DNA Cytometry for Differentiation Between Low- and Mediumgrade Dysplasia in Intraductal Papillary Mucinous Neoplasms

DNA ploidy analysis of mucinous cystic tumors of the pancreas: Correlation of aneuploidy with malignancy and poor prognosis

Flow cytometric analysis of nuclear DNA content of duct cell carcinoma of the pancreas

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