PLLA scaffold modification using magnetron sputtering of the copper target to provide antibacterial properties

Badaraev, Arsalan D.; Nemoykina, Anna L.; Bolbasov, E. N.; Tverdokhlebov, Sergei I.

doi:10.1016/j.reffit.2017.05.004

Cited by 12 publications

(12 citation statements)

References 41 publications

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“…PLLA is also known to be biocompatible, which makes it an excellent candidate for pharmaceutical and biomedical applications [19]. Using the previously reported methodology based on electrospinning [20], PLLA scaffold was prepared and then kindly supplied to us by Drs. S. Tverdokhlebov and E. Bolbasov (Tomsk Polytechnic University).…”

Section: Methodsmentioning

confidence: 99%

Comparative Study of Physicochemical and Antibacterial Properties of ZnO Nanoparticles Prepared by Laser Ablation of Zn Target in Water and Air

et al. 2019

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Here, we report on ZnO nanoparticles (NPs) generated by nanosecond pulsed laser (Nd:YAG, 1064 nm) through ablation of metallic Zn target in water and air and their comparative analysis as potential nanomaterials for biomedical applications. The prepared nanomaterials were carefully characterized in terms of their structure, composition, morphology and defects. It was found that in addition to the main wurtzite ZnO phase, which is conventionally prepared and reported by others, the sample laser generated in air also contained some amount of monoclinic zinc hydroxynitrate. Both nanomaterials were then used to modify model wound dressings based on biodegradable poly l-lactic acid. The as-prepared model dressings were tested as biomedical materials with bactericidal properties towards S. aureus and E. coli strains. The advantages of the NPs prepared in air over their counterparts generated in water found in this work are discussed.

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Section: Methodsmentioning

confidence: 99%

Comparative Study of Physicochemical and Antibacterial Properties of ZnO Nanoparticles Prepared by Laser Ablation of Zn Target in Water and Air

et al. 2019

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“…Polymer microspheres [126], thin films [127], and fibers [128] have been coated with Ag [107,108,129], Cu [130], Ti [131], TiO 2 [132], gold (Au) [133], hydroxyapatite (HAP), tricalcium phosphate (TCP) [134], amorphous calcium pyrophosphate (CPP) [134], and dicalcium phosphate dihydrate (DCPD) [134] for different biomedical applications.…”

Section: Combination Of Electrospinning and Sputtering Technologiementioning

confidence: 99%

“…Cu is cheaper than Ag; therefore, Cu coating can provide economical wound dressing mats [154,155]. A PLA scaffold was DC magnetron sputter-coated with copper (Cu) [130]. The PLLA scaffold had increased hydrophobicity, proportional to plasma treatment time.…”

Section: Combination Of Electrospinning and Sputtering Technologiementioning

confidence: 99%

Sputtering of Electrospun Polymer-Based Nanofibers for Biomedical Applications: A Perspective

2019

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Electrospinning has gained wide attention recently in biomedical applications. Electrospun biocompatible scaffolds are well-known for biomedical applications such as drug delivery, wound dressing, and tissue engineering applications. In this review, the synthesis of polymer-based fiber composites using an electrospinning technique is discussed. Formerly, metal particles were then deposited on the surface of electrospun fibers using sputtering technology. Key nanometals for biomedical applications including silver and copper nanoparticles are discussed throughout this review. The formulated scaffolds were found to be suitable candidates for biomedical uses such as antibacterial coatings, surface modification for improving biocompatibility, and tissue engineering. This review briefly mentions the characteristics of the nanostructures while focusing on how nanostructures hold potential for a wide range of biomedical applications.

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“…The diameters of fibers range from 0.8 to 2 μm. Testing for antibacterial features indicated that the modified scaffolds are capable to have a bacteriostatic effect [41].…”

Section: Copper-based Nanomaterials (Cunps)mentioning

confidence: 99%

Poly(L-Lactide) Bionanocomposites

Chakoli¹

2019

Peptide Synthesis

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A variety of natural, synthetic, and biosynthetic polymers such as poly(L-lactide), polyhydroxyalkanoate, and poly(ε-caprolactone) are biocompatible and environmentally degradable. Biodegradability can therefore be engineered into polymers by the judicious addition of chemical linkages such as anhydride, ester, or amide bonds, among others. Poly(L-lactide) (PLLA) has attracted increasing attention due to the combination of its bioresorbability, biodegradability, biocompatibility, and shape memory effect. It has been widely applied to biomedical fields such as bone screws, surgical sutures, tissue engineering, and controlled drug delivery. Nevertheless, the PLLA is weaker than that of natural cortical bones in mechanical strength. Additionally, the ability of PLLA in cell attachment and bioactivity are weak due to its hydrophobic properties. In order to overcome the unsuitable properties of PLLA, various techniques have already been applied to modify the physical and mechanical properties of PLLA. The most significant method is to introduce some various kinds of fillers into PLLA matrix to provide reinforcing filler/PLLA composites, such as hydroxyapatite (HA), b-tricalcium phosphate, bioglass, silica gel, amorphous carbon, carbon nanotubes (CNTs), and so on.

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PLLA scaffold modification using magnetron sputtering of the copper target to provide antibacterial properties

Cited by 12 publications

References 41 publications

Comparative Study of Physicochemical and Antibacterial Properties of ZnO Nanoparticles Prepared by Laser Ablation of Zn Target in Water and Air

Comparative Study of Physicochemical and Antibacterial Properties of ZnO Nanoparticles Prepared by Laser Ablation of Zn Target in Water and Air

Sputtering of Electrospun Polymer-Based Nanofibers for Biomedical Applications: A Perspective

Poly(L-Lactide) Bionanocomposites

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