PLLA‐Grafted Gelatin Amphiphilic Copolymer and Its Self‐Assembled Nano Carrier for Anticancer Drug Delivery

Abstract

A series of poly(l‐lactide)‐grafted gelatin (Gel‐g‐PLLA) copolymers are synthesized by coupling the amino groups of gelatin with different molar masses and the carboxyl endgroup of poly(l‐lactide) in the presence of 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride and N‐hydroxysuccinimide. Fourier transform infrared and nuclear magnetic resonance (1H NMR) data confirm the successful bonding between gelatin and PLLA. Self‐assembled micelles of copolymers are prepared by using the direct dissolution method. The size and micellar morphology are determined from dynamic light scattering as well as transmission electron microscopy measurements. Meanwhile, in vitro drug release reveals that Gel‐g‐PLLA micelles show excellent sustained‐release properties when used as the carrier of the anticancer drug paclitaxel. A burst release of about 70% is observed in the first 24 h. All these features, together with the outstanding biocompatibility, make Gel‐g‐PLLA micelles a promising drug carrier for cancer therapy.

RETRACTED: Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

“…[ 4,5 ] To further improve the efficiencies of the established drugs, various treatment strategies, such as preparation of protein–drug conjugates and the design of nanoscale drug‐carriers, are used to increase the efficacy of therapeutic agents. [ 6–8 ] Several effective nano‐carrier systems were designed to deliver anti‐cancer cytotoxic agents to tumor cells with high selectivity and efficacy while minimizing negative side effects. [ 9,10 ] Drug nano‐carriers provide multiple advantages, such as convenient uptake and internalization, reduced drug interactions, optimized lifetime, and widened therapeutic windows.…”

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

“…However, most of the HAP particles are embedded in the PLLA matrix for the HAP/PLLA composite scaffold. Moreover, PLLA displays very slow degradation rate ranging from 6 months to 3 years for complete degradation due to the hydrophobic methyl group in its backbone [ 13 , 14 ], which acts as a physical barrier inhibiting the contact between the HAP particles and body fluid. Therefore, how to accelerate the degradation rate of HAP/PLLA composite scaffold so that the HAP particles can be exposed from the PLLA matrix to body fluid is an urgent problem to be solved.…”

Surface Modification of PTLG Terpolymer Using PNIPAAm and Its Cell Adhesion/Detachment Behavior

“…outstanding mechanical strength of pure poly(l-lactide) (PLLA) makes it one of the most promising tissue engineering scaffold material. [1,2] But the main drawback of pure PLLA is low hydrophilicity, slow degradation, poor toughness and acidic degradation products that may lead to inflammatory reactions. It has been explored as an effective method to copolymerization of LLA with 1,3-trimethylene carbonate (TMC) and GA for tailoring the mechanical properties and degradation rate of PLLA-based materials.…”

“…Biodegradable polymer materials have attracted great attention in recent decades due to its biodegradability, biocompatibility and producibility from renewable resources. Among polylactide (PLA), poly(ε‐caprolactone) (PCL), and polyglycolide(PGA), outstanding mechanical strength of pure poly( l ‐lactide) (PLLA) makes it one of the most promising tissue engineering scaffold material 1,2. But the main drawback of pure PLLA is low hydrophilicity, slow degradation, poor toughness and acidic degradation products that may lead to inflammatory reactions.…”