2017
DOI: 10.1038/srep46017
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Plk1 Regulates the Repressor Function of FoxM1b by inhibiting its Interaction with the Retinoblastoma Protein

Abstract: FoxM1b is a cell cycle-regulated transcription factor, whose over-expression is a marker for poor outcome in cancers. Its transcriptional activation function requires phosphorylation by Cdk1 or Cdk2 that primes FoxM1b for phosphorylation by Plk1, which triggers association with the co-activator CBP. FoxM1b also possesses transcriptional repression function. It represses the mammary differentiation gene GATA3 involving DNMT3b and Rb. We investigated what determines the two distinct functions of FoxM1b: activati… Show more

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Cited by 14 publications
(10 citation statements)
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References 64 publications
(97 reference statements)
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“…There was no significant difference in FoxA2 expression in the G 2 -M phases (Fig. 5F) because FoxM1 is phosphorylated by Plk1, which blocks binding to Rb (25). We repeated this experiment with 3 independent clones of FoxM1-shRNA cells and observed similar results.…”
Section: Foxm1 Inhibits Foxa2 In G 1 and Stimulates Pluripotency Genesupporting
confidence: 53%
“…There was no significant difference in FoxA2 expression in the G 2 -M phases (Fig. 5F) because FoxM1 is phosphorylated by Plk1, which blocks binding to Rb (25). We repeated this experiment with 3 independent clones of FoxM1-shRNA cells and observed similar results.…”
Section: Foxm1 Inhibits Foxa2 In G 1 and Stimulates Pluripotency Genesupporting
confidence: 53%
“…Others have reported DNA methylation at the GATA3 CGI in breast cancer 43,44 bladder cancer 45 and some leukaemias 46 , with direct evidence that DNA methylation regulates GATA3 expression 46,47 . In our results, GATA3 methylation was confined to the start of the GATA3 antisense transcript (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…By transferring phosphate group from ATP to substrates, PLK1 control various G2/M associated cellular processes, namely centrosome maturation, checkpoint recovery, spindle assembly, cytokinesis, and apoptosis. Also, PLK1 phosphorylation sites in FOXM1B serves as a regulator for its repressor function in G1 phase and activator function in S and G2/M phase ( 127 ). FOXM1 has two potential PBD-binding sites (T596 and S678) at its C terminal region and phosphorylate S715 and S724 present within the TAD region of FOXM1 ( 128 ).…”
Section: Regulation Of Foxm1mentioning
confidence: 99%