Plithotaxis, a collective cell migration, regulates the sliding of proliferating pulp cells located in the apical niche

Hirata, Azumi; Dimitrova-Nakov, Sasha; Djole, Stéphane-Xavier; Ardila, Hector; Baudry, Anne; Kellermann, Odile; Simon, Stéphane; Goldberg, Michel

doi:10.3109/03008207.2014.923855

Cited by 15 publications

(11 citation statements)

References 9 publications

(10 reference statements)

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“…To accomplish this, a source of progenitor cells (erroneously referred to as 'SCs') is required. These cells must first be directed from their niche to the damaged area through chemotaxis or plithotaxis (Hirata et al 2014). Once the cells have migrated to contact the biomaterial, they must differentiate into mineral-secreting cells, at which point dentine synthesis is triggered.…”

Section: Is Pulp Exposure a Negative Factor?mentioning

confidence: 99%

Management of deep caries and the exposed pulp

et al. 2019

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Caries prevalence remains high throughout the world, with the burden of disease increasingly affecting older and socially disadvantaged groups in Western cultures. If left untreated, caries will advance through dentine stimulating pulpitis and eventually pulp infection and necrosis; however, if conservatively managed, pulpal recovery occurs even in deep carious lesions. Traditionally, deep caries management was destructive with nonselective (complete) removal of all carious dentine; however, the promotion of minimally invasive biologically based treatment strategies has been advocated for selective (partial) caries removal and a reduced risk of pulp exposure. Selective caries removal strategies can be one‐visit as indirect pulp treatment or two‐visit using a stepwise approach. Management strategies for the treatment of the cariously exposed pulp are also shifting with avoidance of pulpectomy and the re‐emergence of vital pulp treatment (VPT) techniques such as partial and complete pulpotomy. These changes stem from an improved understanding of the pulp–dentine complex's defensive and reparative response to irritation, with harnessing the release of bioactive dentine matrix components and careful handling of the damaged tissue considered critical. Notably, the development of new pulp capping materials such as mineral trioxide aggregate, which although not an ideal material, has resulted in more predictable treatments from both a histological and a clinical perspective. Unfortunately, the changes in management are only supported by relatively weak evidence with case series, cohort studies and preliminary studies containing low patient numbers forming the bulk of the evidence. As a result, critical questions related to the superiority of one caries removal technique over another, the best pulp capping biomaterial or whether pulp exposure is a negative prognostic factor remain unanswered. There is an urgent need to promote minimally invasive treatment strategies in Operative Dentistry and Endodontology; however, the development of accurate diagnostic tools, evidence‐based management strategies and education in management of the exposed pulp are critical in the future.

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Section: Is Pulp Exposure a Negative Factor?mentioning

confidence: 99%

Management of deep caries and the exposed pulp

et al. 2019

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“…These cells migrate from the central part of the pulp to the lateral subodontoblastic boundaries. Then, they slide from the root towards the coronal part of the pulp where they underwent terminal differentiation (Hirata et al 2014), suggesting that apical progenitor cells are mobilized and contribute to pulp regeneration. In vitro, all these heterogeneous cell populations (DPSCs, SHEDs, SCAPs) have the ability to differentiate into odontoblasts, osteoblasts, and adipocytes as well as even into neuron-like cells.…”

Section: Cell Sources For Tooth Regenerationmentioning

confidence: 99%

From pulpal stem cells to tooth repair: an emerging field for dental tissue engineering

et al. 2016

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In current dental practices, traditional restorative approaches may have relatively limited long-term survival and may be associated to diverse complications, such as allergy, pulpitis, or periodontal pathologies. To overcome these shortcomings, novel innovative strategies have been envisioned for tooth repair. During the two last decades, the extensive advances in our understanding of tooth development as well as stem cell research provide the foundation for exciting opportunities in dental tissue engineering. The replacement of lost teeth by engineered dental tissue appears as a fascinating goal. However, the feasibility remains an intriguing question. Is the challenge to create a new tooth acting as a substitute for lost tooth or to regenerate only part of this organ that is enamel, dentin, or dental pulp? Is it possible to exploit stem cells for transplantation purposes to promote matrix formation and mineralization in the framework of endodontic treatment? Finally, investigating the functional properties of pulpal stem cells is however mandatory to envision novel therapeutic dental strategies. In this review, we summarize the current knowledge of stem cells used for dental tissue engineering and discuss the ensuing challenges for regenerative dentistry.

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“…They multiply and slide in the root pulp beneath the odontoblast/sub-odontoblast layers. PCNA labeled cells are located mainly in the apical part [20]. Six et al, [21] have shown that after 2 weeks, labeled cells become undetectable in the root.…”

Section: Dental Pulp Regeneration and Mineralizationmentioning

confidence: 99%

Root Canal Treatment (RCT): From Traditional Endodontic Therapies to Innovating Pulp Regeneration

Goldberg¹

2016

JDODT

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Traditional protocols involve the cleaning of the pulp chamber and root canals, the removal of bacteria and of the smear layer, and ultimately to the sealing of endodontic materials filling the pulp, and root lumen. Disinfection combined with mechanical enlargement allows occluding the lumen of the dental pulp with a central master cone, and lateral condensation using a series of small accessory cones. Innovative approaches propose bioengineered scaffolds, growth and transcription factors. Removal of the smear layer reveals different types of globular and non-globular dentins (osteodentin, osteodentin, fibrodentin), cleaning the dentinal walls before chemical or mechanical enlargement of the lumen. Three distinct options open gates for classical endodontic therapies before conventional filling. New pulp therapies derived from apexogenesis and apexification contributes to the formation of a renewed dental pulp, involving totipotent, multipotent and unipotent stem cell. Proliferation of structural cells, signaling factors, transcription factors, metalloproteinases, and cytokines are involved in pulp renewal. Coronal and root microvascularization participate to pulp regeneration and ultimately to pulp mineralization. BMP-2, TGF-β1, MTA and Portland cement may also contribute to the requirements for pulp bioengineering, leading to the future of innovating biological pulp therapies. Dental caries are mostly due to bacteria and subsequently to pulp infection [3]. Associated to the dental plaque; microorganisms alter enamel surface, either beneath the proximal contacts areas, or in the face-to-face enamelling occlusal fissures. The initial carious lesions is formed at this precocious stage. The carious lesion crosses the whole enamel thickness and spread laterally along the enlarged dentino-enamel junction. The lesion degrades firstly the mantle dentin. Caries penetrate the subjacent circumpulpal dentin through dentinal tubules

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Plithotaxis, a collective cell migration, regulates the sliding of proliferating pulp cells located in the apical niche

Cited by 15 publications

References 9 publications

Management of deep caries and the exposed pulp

Management of deep caries and the exposed pulp

From pulpal stem cells to tooth repair: an emerging field for dental tissue engineering

Root Canal Treatment (RCT): From Traditional Endodontic Therapies to Innovating Pulp Regeneration

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