Plication of the free wall of the left ventricle in dogs with doxorubicin-induced cardiomyopathy

Andrade, James Newton Bizetto Meira de; Camacho, Aparecido Antônio; Santos, Paulo Sérgio Patto dos; Fantinatti, Alexandra Pinheiro; Nunes, Newton; Stopiglia, Angelo João

doi:10.2460/ajvr.2005.66.238

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Left ventricle FS was significantly reduced in animals treated with doxorubicin, confirming systolic function impairment. The finding is in agreement with previous studies [58–61] with significant deterioration of FS after 4 weeks of doxorubicin treatment [62]. In the present study, there was no evidence of lycopene effect on FS until 1 week of doxorubicin therapy was completed.…”

Section: Discussionsupporting

confidence: 94%

Effect of Lycopene on Doxorubicin‐Induced Cardiotoxicity: An Echocardiographic, Histological and Morphometrical Assessment

Ferreira

Russell

Rocha

et al. 2007

Basic Clin Pharma Tox

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Doxorubicin is an excellent chemotherapeutic agent utilized for several types of cancer but the irreversible doxorubicin-induced cardiac damage is the major limitation for its use. Oxidative stress seems to be associated with some phase of the toxicity mechanism process. To determine if lycopene protects against doxorubicin-induced cardiotoxicity, male Wistar rats were randomly assigned either to control, lycopene, doxorubicin or doxorubicin + lycopene groups. They received corn oil (control, doxorubicin) or lycopene (5 mg /kg body weight a day) (lycopene, doxorubicin + lycopene) by gavage for a 7-week period. They also received saline (control, lycopene) or doxorubicin (4 mg/kg) (doxorubicin, doxorubin + lycopene) intraperitoneally by week 3, 4, 5 and 6. Animals underwent echocardiogram and were killed for tissue analyses by week 7. Mean lycopene levels (nmol/kg) in liver were higher in the doxorubicin + lycopene group (5822.59) than in the lycopene group (2496.73), but no differences in lycopene were found in heart or plasma of these two groups. Lycopene did not prevent left ventricular systolic dysfunction induced by doxorubicin. However, morphologic examination revealed that doxorubicin-induced myocyte damage was significantly suppressed in rats treated with lycopene. Doxorubicin treatment was followed by increase of myocardium interstitial collagen volume fraction. Our results show that: (i) doxorubicin-induced cardiotoxicity was confirmed by echocardiogram and morphological evaluations; (ii) lycopene absorption was confirmed by its levels in heart, liver and plasma; (iii) lycopene supplementation provided myocyte protection without preventing interstitial collagen accumulation increase; (iv) doxorubicin-induced cardiac dysfunction was not prevented by lycopene supplementation; and (v) lycopene depletion was not observed in plasma and tissues from animals treated with doxorubicin.

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Section: Discussionsupporting

confidence: 94%

Effect of Lycopene on Doxorubicin‐Induced Cardiotoxicity: An Echocardiographic, Histological and Morphometrical Assessment

Ferreira

Russell

Rocha

et al. 2007

Basic Clin Pharma Tox

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AN ASSESSMENT OF ECHOCARDIOGRAPHY AS A DIAGNOSTIC TOOL FOR DILATED CARDIOMYOPATHY IN TURKEY (<i>MELEAGRIS GALLOPAVO</i>)

Ali¹

2012

American Journal of Animal and Veterinary Sciences

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Our understanding of the etiology of Dilated Cardiomyopathy (DCM), which affects about 5% of turkeys, is limited. This limitation may be due to the lack of an easy-to-use diagnostic tool with well-defined parameters and does not involve necropsy. This lack of a widely tested non-necropsy method makes it difficult for a largescale study of the genetic factors that underlie DCM. Here, we Evaluated Echocardiography (ECHO) for its ease and reliability for identifying DCM-affected turkeys from hatch to four weeks-of-age. The parameters evaluated included Left Ventricular Internal-Diastolic (LVIDd), Internal-Systolic Dimension (LVISd), Interventricular Septum End-Diastolic (IVSEd), Interventricular Septum End-Systolic (IVSEs), Left Ventricular Wall End-Systolic (LVWEs) and Left Ventricular Wall End-Diastolic (LVWEd). To induce DCM, feed containing 700 ppm of Furazolidone (Fz) was fed to turkey poults from one to 28 days-of-age. The LVIDd and LVISd were the most consistent indicators of DCM. Both parameters revealed differences between control and treatment poults of between 25 and 326% at the 4 ages at which ECHO measurements were taken. The average difference in LVIDd between control and poults fed Fz-containing diets ranged from 25% in one week-old to 80% in 4-week-old poults. At similar ages, average differences between control and poults fed Fz-containing diets in LVISd were 74 and 326% respectively. Necropsy of poults that survived to the end of the 4-week Fz-treatment confirmed these ECHO measurements in treatment and normal poults. Our data suggest that using LVIDd and LVISd as parameters make ECHO a reliable tool for identifying DCM in turkeys.

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Plication of the free wall of the left ventricle in dogs with doxorubicin-induced cardiomyopathy

Abstract: Plication of the free wall of the left ventricle improved left ventricular systolic function in dogs with doxorubicin-induced cardiomyopathy. Additional studies are needed to evaluate its application in dogs with naturally developing DCM.

Cited by 2 publications

References 19 publications

Effect of Lycopene on Doxorubicin‐Induced Cardiotoxicity: An Echocardiographic, Histological and Morphometrical Assessment

Effect of Lycopene on Doxorubicin‐Induced Cardiotoxicity: An Echocardiographic, Histological and Morphometrical Assessment

AN ASSESSMENT OF ECHOCARDIOGRAPHY AS A DIAGNOSTIC TOOL FOR DILATED CARDIOMYOPATHY IN TURKEY (<i>MELEAGRIS GALLOPAVO</i>)

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