PLGA nanoparticles introduction into mitoxantrone-loaded ultrasound-responsive liposomes: In vitro and in vivo investigations

Xin, Yuxuan; Qi, Qi; Mao, Zhuo; Zhan, Xiaoping

doi:10.1016/j.ijpharm.2017.05.059

Cited by 30 publications

(25 citation statements)

References 38 publications

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“…Tepotecan-loaded US responsive MSNs showed a significant reduction in viability (~50%) of human osteosarcoma cells after 24 hours in the presence of ultrasound as compared to that without ultrasound exposure (~100%) [42]. In another report, Xin et al [76] used PLGA nanoparticles to induce ultrasound responsive vibrations, which destabilized the membrane of liposomes enclosing PLGA NPs. Mitoxantrone-loaded US-sensitive liposomes showed enhanced drug release in the presence of US (~90%) as compared to that without US stimulus (~50%) after 10 hours.…”

Section: Exogenous Stimuli-responsive Ddsmentioning

confidence: 99%

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

et al. 2019

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In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. This particular work focuses on the smart chemistry and mechanism of action aspects of several types of stimuli-responsive polymeric carriers that play a crucial role in extracellular and intracellular sections of diseased tissues or cells. With ever increasing scientific knowledge and awareness, research is underway around the globe to design new types of stimuli (external/internal) responsive polymeric carriers for biotechnological applications at large and biomedical and/or pharmaceutical applications, in particular. Both external/internal and even dual/multi-responsive behavior of polymeric carriers is considered an essential element of engineering so-called ‘smart’ DDS, which controls the effective and efficient dose loading, sustained release, individual variability, and targeted permeability in a sophisticated manner. So far, an array of DDS has been proposed, developed, and implemented. For instance, redox, pH, temperature, photo/light, magnetic, ultrasound, and electrical responsive DDS and/or all in all dual/dual/multi-responsive DDS (combination or two or more from any of the above). Despite the massive advancement in DDS arena, there are still many challenging concerns that remain to be addressed to cover the research gap. In this context, herein, an effort has been made to highlight those concerning issues to cover up the literature gap. Thus, the emphasis was given to the drug release mechanism and applications of endogenous and exogenous based stimuli-responsive DDS in the clinical settings.

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Section: Exogenous Stimuli-responsive Ddsmentioning

confidence: 99%

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

et al. 2019

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“…The flow rate was 1.0 mL/min, the detection wavelength was set at 240 nm, and the column was Agilent ZORBAX 300 SB-C18 column (4.6×250 mm, 5 µm) with a column temperature of 40°C. 27 The drug loading content and encapsulation efficiency of PL/ACC-MIT were determined using the following equations: stability and hemolysis studies ACC-MIT and PL/ACC-MIT nanoparticles were incubated with mouse plasma at 37°C for 2 hours. Moreover, PL/ACC-MIT nanoparticles were incubated with PBS (0.01 M, pH 7.4) or mouse plasma at 37°C for 48 hours.…”

Section: Preparation Of Pl/acc-mitmentioning

confidence: 99%

<p>Mitoxantrone-preloaded water-responsive phospholipid-amorphous calcium carbonate hybrid nanoparticles for targeted and effective cancer therapy</p>

Wang¹,

Han²,

Liu³

et al. 2019

IJN

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Background: The application of mitoxantrone (MIT) in cancer therapy has been severely limited by its inherent drawbacks. In addition, effective cancer therapy calls for drug release systems capable of enforcing drug release within cancer cells in response to infinite stimulant with enhanced drug penetration capability. Methods: MIT-preloaded phospholipid-amorphous calcium carbonate hybrid nanoparticles (PL/ACC-MIT) that surface modified with PL shell (containing shielding polymer polyethylene glycol and targeting moiety folic acid) were prepared by a facile solvent-diffusion method. Results: It has been proven that the resulting PL/ACC-MIT nanoparticles demonstrated satisfactory stability against various aqueous environments with minimal drug leakage and exerted strong targeting capability but selective preference to the folate receptor-overexpressing cell line. In contrast, once exposed to the enzyme-abundant and acidic environments of cancer cells, the PL/ACC-MIT nanoparticles can readily decompose to facilitate quick drug release and enhanced drug penetration to yield preferable antitumor effect both in vitro and in vivo. Conclusion: In this study, MIT-preloaded water-responsive hybrid nanoparticles with increased stability, targetability, controlled drug release, and enhanced drug penetration were successfully developed, which might be a candidate for targeted and effective cancer therapy.

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“…Ultrasound-created strong acoustic cavitation can also disrupt several drug loaded lipidic or polymeric nanoaggregates such as liposomes [104], Pluronic micelles [105], nanobubbles [106], and nanodroplets [101] for ultrasound trigger drug release at the target site. Marin et al .…”

Section: Ultrasound-responsive Nanomaterialsmentioning

confidence: 99%

“…Xin et al . (2017) [104] wrapped PLGA nanoparticles in liposomes and upon insonation the liposomes immediately vibrated and broken down to release the PLGA nanoparticles and the loaded mitoxantrone. Encapsulation of the drug increased its half-life 6.7-fold in adult Sprague-Dawley rats, which again decreased to 1.7-fold upon insonation.…”

Section: Ultrasound-responsive Nanomaterialsmentioning

confidence: 99%

Design strategies for physical-stimuli-responsive programmable nanotherapeutics

Sahle

Gulfam

Lowe

2018

Drug Discovery Today

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Nanomaterials that respond to externally applied physical stimuli such as temperature, light, ultrasound, magnetic field and electric field have shown great potential for controlled and targeted delivery of therapeutic agents. However, the body of literature on programming these stimuli-responsive nanomaterials to attain the desired level of pharmacologic responses is still fragmented and has not been systematically reviewed. The purpose of this review is to summarize and synthesize the literature on various design strategies for simple and sophisticated programmable physical stimuli-responsive nanotherapeutics.

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PLGA nanoparticles introduction into mitoxantrone-loaded ultrasound-responsive liposomes: In vitro and in vivo investigations

Cited by 30 publications

References 38 publications

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

<p>Mitoxantrone-preloaded water-responsive phospholipid-amorphous calcium carbonate hybrid nanoparticles for targeted and effective cancer therapy</p>

Design strategies for physical-stimuli-responsive programmable nanotherapeutics

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