PLGA nanoparticles embedding molybdenum cluster salts: Influence of chemical composition on physico-chemical properties, encapsulation efficiencies, colloidal stabilities and in vitro release

Molybdenum cluster loaded PLGA nanoparticles as efficient tools against epithelial ovarian cancer

“…These activation by light is the main part of photodynamic therapy (PDT). To increase their aqueous solubility, to protect them from rapid degradation by hydrolysis and finally to increase their deposition in tumor region by the enhanced permeability, polymeric nanoparticles were developed as carrier systems with TMB, CMB and CMIF (Brandhonneur et al, 2018;Dollo et al, 2020).…”

“…Singlet oxygen ( 1 g O 2 ) emission measurements were realized by irradiating the 3 CNPs suspensions (TMB, CMB and CMIF, with a P/C ratio of 2.5) with a laser diode (λ exc = 375 nm), using a near infrared photomultiplier tube Hamamatsu H10330C-75 PMT as photon counting detector (Hamamatsu Photonics France, Massy, France). Measurements were performed with ethanol solutions obtained after the release of cluster compounds from CNPs at 1 hour (Dollo et al, 2020), immediately after preparation (D 0 ) and following 5 days of storage in the dark and under refrigeration (D 5 ). 15,20,25,30,40 and 50 µM of cluster and incubated for 6 hours.…”

“…Poly (lactic-co-glycolic acid) (PLGA) is Food and Drug Administration (FDA) approved biodegradable and biocompatible polyester polymer which have been widely used as a carrier for gene, vaccine, protein, and peptide delivery (Acharya and Sahoo, 2011;Danhier et al, 2012). A wide variety of hydrophobic drugs like curcumin, coumarin, and many others have been successfully encapsulated in PLGA as nanoformulations for use in therapeutic applications (Brandhonneur et al, 2018;Dollo et al, 2020;Makadia and Siegel, 2011).…”

“…RG503H as carboxylic acid terminated PLGA with a 50:50 lactic to glycolic ratio was used and several polymer-to-cluster (P/C) mass ratios were tested 1, 2.5 and 5. The characterization of the different CNPs were previously published (Dollo et al, 2020). Singlet oxygen measurements were performed on TMB, CMB and CMIF cluster compounds released from their nanoparticulate delivery system to assess singlet oxygen production.…”

Electrophoretically Deposited Layers of Octahedral Molybdenum Cluster Complexes: A Promising Coating for Mitigation of Pathogenic Bacterial Biofilms under Blue Light

“…1,2,3,4 It is worth mentioning that, in contrast with a typical organic photosensitizer such as porphyrins, singlet oxygen is produced by Mo 6 cluster complexes even in the solid state allowing for the preparation of photosensitizing materials with a high concentration of active cluster complexes. 5 This sensitization ability has been exploited for the design of various functional materials for photodegradation of pollutants, 6 photo/radiosensitized killing of tumor cells, 5,7,8,9,10,11,12 or photodynamic inactivation of bacteria. 13,14,15,16 The high efficacy of this modality in photoinactivation of bacteria stems from the fact that O 2 ( 1  g ) attacks several critical targets of pathogens, thus making their resistance unlikely.…”