PLGA Nanoparticles and Their Versatile Role in Anticancer Drug Delivery

Khan, Iliyas; Gothwal, Avinash; Sharma, Ashok; Kesharwani, Prashant; Gupta, Lokesh Kumar; Iyer, Arun K.; Gupta, Umesh

doi:10.1615/critrevtherdrugcarriersyst.2016015273

Cited by 76 publications

(34 citation statements)

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“…5,37-39 Therefore, it is likely that a fibrous membrane system that generates a fiber architecture and mineral composition will increase the feasibility of tendon to bone healing and may be the key to improve clinical prognosis. PLGA is considered an excellent biomaterial for bone tissue engineering due to its satisfactory biocompatibility, [40][41][42] International Journal of Nanomedicine downloaded from https://www.dovepress.com/ by 44.224.250.200 on 11-Jul-2020 For personal use only. which was also observed in our experiment ( Figures 3A and 5).…”

Section: Discussionmentioning

confidence: 99%

<p>Promoting tendon to bone integration using graphene oxide-doped electrospun poly(lactic-co-glycolic acid) nanofibrous membrane</p>

Su¹,

Wang²,

Jiang³

et al. 2019

IJN

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Background These normal entheses are not reestablished after repair despite significant advances in surgical techniques. There is a significant need to develop integrative biomaterials, facilitating functional tendon-to-bone integration. Materials and methods We fabricated a highly interconnective graphene oxide-doped electrospun poly(lactide-co-glycolide acid) (GO-PLGA) nanofibrous membrane by electrospinning technique and evaluated them using in vitro cell assays. Then, we established rabbit models, the PLGA and GO-PLGA nanofibrous membranes were used to augment the rotator cuff repairs. The animals were killed postoperatively, which was followed by micro-computed tomography, histological and biomechanical evaluation. Results GO was easily mixed into PLGA filament without changing the three dimensional microstructure. An in vitro evaluation demonstrated that the PLGA membranes incorporated with GO accelerated the proliferation of BMSCs and furthered the Osteogenic differentiation of BMSCs. In addition, an in vivo assessment further revealed that the local application of GO-PLGA membrane to the gap between the tendon and the bone in a rabbit model promoted the healing enthesis, increased new bone and cartilage generation, and improved collagen arrangement and biomechanical properties in comparison with repair with PLGA only. Conclusion The electrospun GO-PLGA fibrous membrane provides an effective approach for the regeneration of tendon to bone enthesis.

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Section: Discussionmentioning

confidence: 99%

<p>Promoting tendon to bone integration using graphene oxide-doped electrospun poly(lactic-co-glycolic acid) nanofibrous membrane</p>

Su¹,

Wang²,

Jiang³

et al. 2019

IJN

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“…Several polymers ranging from poly(amino acids), poly(alkyl‐α‐cyanoacrylates), polyamides, polyesters, polyorthoesters, polyacrylamides and polyurethanes offers a significant advantage in drug‐delivery applications . Among them, USFDA approved PLGA co‐polymers owing to excellent biocompatibility and biodegradability have emerged as an ideal choice in fabrication of polymeric NPs especially for cancer related applications . PLGA NPs offers a versatile platform to co‐encapsulate multiple water soluble/insoluble compounds via double water‐in‐oil‐in‐water or single oil‐in‐water emulsion techniques respectively, of which later is commonly practiced to load hydrophobic therapeutic compounds .…”

Section: Cyanine Nanoprobes In Cancer Theranosticsmentioning

confidence: 99%

Cyanine based Nanoprobes for Cancer Theranostics

Bhattarai

Dai

2017

Adv Healthcare Materials

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Cyanine dyes are greatly accredited in the development of non‐invasive therapy that can “see” and “treat” tumor cells via imaging, photothermal and photodynamic treatment. However, these dyes suffer from poor pharmacokinetics inducing severe toxicity to normal cells, insufficient accumulation in tumor regions and rapid photobleaching when delivered in free forms. Nanoparticles engineered to encapsulate these compounds and delivering them into tumor regions have increased rapidly, however, so far, these nanoparticles (NPs) have not proved to be so effective to circumvent existing challenges. Newly designed multifunctional smart nanocarriers that can improve phototherapeutic properties of these dyes, co‐encapsulate multiple potent therapeutic compounds, and simultaneously overcome limitations related to tumor recurrence, metastases, limited intracellular uptake, and tumor hypoxia have potential to revolutionize modern paradigm of cancer therapy. Such cyanine based multifunctional nanocarriers integrating imaging and therapy in a single platform can effectively produce better clinical outcomes in cancer treatment. This review briefly summarizes recent advancements of cyanine nanoprobes that are currently used as imaging/phototherapeutic agents in unimodal/bimodal/trimodal cancer theranostics. Finally, we conclude this review by addressing challenges of pre‐existing therapeutic systems and designs adopted to overcome them with a brief insight assimilating future perspective of emerging cyanine‐based NPs in cancer theranostics.

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“…Biodegradable PLGA has approved as pharmaceutic adjuvant by FDA (Food and Drug Administration) Certi cation [27]. The degradation products of PLGA are lactic acid and glycolic acid, which are also the body's normal metabolic intermediate.…”

Section: Biocompatibility Of the Plga Nanoparticlesmentioning

confidence: 99%

Paclitaxel-Loaded and Folic Acid Modified PLGA Nanomedicine with Glutathione-Response for the Treatment of Lung Cancer

Zhang

Wang

Yao

et al. 2020

Preprint

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Targeted delivery and smart response of nanomedicine hold great promise to improve the therapeutic efficacy and alleviate the side effects of chemotherapy agents in cancer treatment. While a few research systems about organic nanomedicines with these properties have limited the development prospect of nanomedicines. In the present study, folic acid (FA) targeted delivery and GSH (glutathione) smart responsive nanomedicine was rationally designed for paclitaxel (PTX) delivery in the treatment of lung cancer. Compared with other stimuli responsive nanomedicines, this nano-carrier was not only sensitive to biologically relevant GSH for on demand drug release but also biodegradable into biocompatible by products after fulfilling its delivering task. The nanomedicine can firstly enter into tumor cells via FA and its receptor mediated endocytosis. After lysosomes escape, the PLGA (poly(lactic-co-glycolic acid) nanomedicine was triggered by the higher level of GSH and released its cargo in tumor microenvironment. In vitro and in vivo results revealed that the PLGA nanomedicine not only can inhibit the proliferation and promote the apoptosis of lung cancer cells greatly, but also possesses less toxic side effects when compared with free PTX. Therefore, the proposed drug delivery system demonstrates the encouraging potential for multifunctional nano-platform applicable to enhance the bioavailability and reduce the side effects of chemotherapy agents.

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PLGA Nanoparticles and Their Versatile Role in Anticancer Drug Delivery

Cited by 76 publications

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<p>Promoting tendon to bone integration using graphene oxide-doped electrospun poly(lactic-co-glycolic acid) nanofibrous membrane</p>

<p>Promoting tendon to bone integration using graphene oxide-doped electrospun poly(lactic-co-glycolic acid) nanofibrous membrane</p>

Cyanine based Nanoprobes for Cancer Theranostics

Paclitaxel-Loaded and Folic Acid Modified PLGA Nanomedicine with Glutathione-Response for the Treatment of Lung Cancer

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