PLGA-microsphere mediated clearance of bilirubin in temporarily hyperbilirubinemic rats: An alternate strategy for the treatment of experimental jaundice

Preparation and adsorption property of aminated cross linking microbeads of GMA/EGDMA for bilirubin

“…1,2 However, due to a disorder of the liver system in patients, the metabolic pathway of bilirubin is blocked and the amount of unconjugated bilirubin in blood increases. Which interferes with the normal functioning of the cellular machinery and eventually manifests systemic toxicity, 1 and further may result in fatal kernicterus, 3,4 and acute renal failure. 5 An effective treatment for hyperbilirubinemia is hemoperfusion treatment, and a successful hemoperfusion technique requires the absorbent to be of specific, of high adsorption capacity and blood compatible and biocompatible.…”

Studies on preparing and adsorption property of grafting terpolymer microbeads of PEI-GMA/AM/MBA for bilirubin

“…The free bilirubin is a lipophilic endotoxin, and under normal physiological conditions, it is transported to liver by albumin for conjugation and subsequent excretion [1,2]. However, in certain pathological conditions such as jaundice, the amount of unconjugated bilirubin in blood increases and the elevated bilirubin level interferes with the normal functioning of the cellular machinery and eventually manifests systemic toxicity [1], and further may result in fatal kernicterus [3,4]. An effective treatment for hyperbilirubinemia is hemoperfusion treatment, and a successful hemoperfusion technique requires the absorbent to be specific, of high adsorption capacity and blood compatible and biocompatible [5,6].…”

US-guided interstitial chemotherapy using paclitaxel temperature-responsive gel for breast cancer treatment in rat

“…Some sustained-release reagents, such as liposomes, microspheres and gels, are emerging (Ahmad et al 2006;Ravivarapu et al 2000;Jain et al 2007a, b;Ghahremankhani et al 2008). With the development of sustained-release techniques and renewable drug delivery systems, interstitial chemotherapy is gradually being considered an effective approach for tumor treatment.…”