PLGA–HPMC nanoparticles prepared by a modified supercritical anti-solvent technique for the controlled release of insulin

Zabihi, Fatemeh; Yang, Miao; Leng, Yuanpeng; Zhao, Yaping

doi:10.1016/j.supflu.2015.01.023

Cited by 25 publications

(10 citation statements)

References 31 publications

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“…Several mucoadhesive polymers including hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP), carbopol, chitosan, carboxymethylcellulose, and poloxamer 407 (P407) have been utilized in controlled-release drug delivery systems. HPMC, a hydrophilic and non-ionic cellulose [ 1 , 2 ] with high swelling and bioadhesive properties [ 3 ], has been used in combination with P407 and PVP to form a mucoadhesive gel incorporating melatonin (MLT)-encapsulated niosomes, providing transmucosal delivery and prolonged release of MLT in the oral cavity [ 4 ]. Chitosan, a cationic polyaminosaccharide deacetylated from chitin, has been shown to interact with negatively charged mucin and enhance penetration through epithelial tight junctions [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Characteristic Evaluation of Gel Formulation Containing Niosomes of Melatonin or Its Derivative and Mucoadhesive Properties Using ATR-FTIR Spectroscopy

et al. 2021

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Chitosan or polyvinyl pyrrolidone (PVP) were used in combination with hydroxypropyl methylcellulose (HPMC) and poloxamer 407 (P407) as gelling agents for oral drug delivery. The performance interaction with mucin of chitosan-composed gel (F1) and PVP-composed gel (F2) was compared using attenuated total reflectance–Fourier-transform infrared (ATR-FTIR) spectroscopy at controlled temperatures of 25 and 37 °C for 1 and 5 min. F1 containing niosome-entrapped melatonin or its derivatives was investigated for mucoadhesive interaction on mucosa by ATR-FTIR spectroscopy under the same conditions. The results showed that F1-treated mucin gave a significantly lower amide I/amide II ratio than untreated mucin and F2-treated mucin did within 1 min, suggesting improved rapid affinity between mucin and chitosan. The spectra of mucosa treated with F1 incorporating niosomes of melatonin or its derivatives showed peak shifts at C=O (amide I), N-H (amide II), and carbohydrate regions and an associated decrease in the amide I/amide II ratio and increase in the carbohydrate/amide II ratio. These results indicated electrostatic interaction and hydrogen bonding between chitosan and mucin on the mucosa. In conclusion, the molecular interaction between gels and mucin/mucosa detected at amide I and amide II of proteins and the carbohydrate region could lead to an improved mucoadhesive property of the gel on the mucosa.

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Section: Introductionmentioning

confidence: 99%

Characteristic Evaluation of Gel Formulation Containing Niosomes of Melatonin or Its Derivative and Mucoadhesive Properties Using ATR-FTIR Spectroscopy

et al. 2021

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“…[109][110][111] In this case, HPMC was blended with different kinds of polymers, such as PVP, 112 CS, 113 EC, 114 gelatin, and xanthan gum 115 and in most cases, these blends showed remarkable controlled release activity. [116][117][118][119] Dharmalingam et al designed a combination of HPMC and NaCMC in the presence of citric acid (CA) as a crosslinking agent (citric acid crosslinked HPMC-NaCMC hydrogel films) in order to evaluate the controlled release of methylene blue and TCH for wound healing applications. The loading efficacy for the drugs reversed for different ratios of CA at a pH 7.4 and 37°C.…”

Section: Applications Of Cellulose and Its Blend Derivative In Cddssmentioning

confidence: 99%

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

Maghsoudi¹,

Shahraki²,

Rabiee³

et al. 2020

IJN

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With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.

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“…. To date, the SCF technique itself has already been used to prepare many nanomaterials including nanoparticles, nanoemulsions, and liposomes . In these studies, SCF can be used either as a solvent for rapid expansion of supercritical solution process or as an antisolvent for supercritical antisolvent process based on the solubility of nanomaterials in SCFs.…”

Section: Summary and Future Perspectivementioning

confidence: 99%

Nanomaterial Preparation by Extrusion through Nanoporous Membranes

Guo

Huang

Zhao

et al. 2018

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Template synthesis represents an important class of nanofabrication methods. Herein, recent advances in nanomaterial preparation by extrusion through nanoporous membranes that preserve the template membrane without sacrificing it, which is termed as "non-sacrificing template synthesis," are reviewed. First, the types of nanoporous membranes used in nanoporous membrane extrusion applications are introduced. Next, four common nanoporous membrane extrusion strategies: vesicle extrusion, membrane emulsification, precipitation extrusion, and biological membrane extrusion, are examined. These methods have been utilized to prepare a wide range of nanomaterials, including liposomes, emulsions, nanoparticles, nanofibers, and nanotubes. The principle and historical context of each specific technology are discussed, presenting prominent examples and evaluating their positive and negative features. Finally, the current challenges and future opportunities of nanoporous membrane extrusion methods are discussed.

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PLGA–HPMC nanoparticles prepared by a modified supercritical anti-solvent technique for the controlled release of insulin

Cited by 25 publications

References 31 publications

Characteristic Evaluation of Gel Formulation Containing Niosomes of Melatonin or Its Derivative and Mucoadhesive Properties Using ATR-FTIR Spectroscopy

Characteristic Evaluation of Gel Formulation Containing Niosomes of Melatonin or Its Derivative and Mucoadhesive Properties Using ATR-FTIR Spectroscopy

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

Nanomaterial Preparation by Extrusion through Nanoporous Membranes

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