PLGA-CTAB curcumin nanoparticles: Fabrication, characterization and molecular basis of anticancer activity in triple negative breast cancer cell lines (MDA-MB-231 cells)

Meena, Ramovatar; Kumar, Sumit; Kumar, Raj; Gaharwar, Usha Singh; Paulraj, R

doi:10.1016/j.biopha.2017.07.151

Cited by 42 publications

(24 citation statements)

References 40 publications

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“…The effects of CUR on cell cycle may be attributed to what has been studied previously in TNBC using polymeric based CUR encapsulation [94]. CUR has been found to cause cell cycle arrest at G1/S and G2/M phase in TNBC cells.…”

Section: Discussionmentioning

confidence: 68%

“…CUR has been found to cause cell cycle arrest at G1/S and G2/M phase in TNBC cells. Cell cycle arrest has been associated with the production of reactive oxygen species resulting from CUR treatment leads to DNA damage and reductions in CDK2, CDK4, cyclin D1 and cyclin E because of p38-MAPK activation [94]. Cell cycle arrest in the G2/M phase has been noted in previous work by Dhule et al which compared the use of curcumin liposomes, coencapsulated curcumin and C6 ceramide liposomes, in addition to folate decorated CUR-C6 ceramide combination liposomes in the treatment of osteosarcoma in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

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Liposomes Aid Curcumin's Combat with Cancer in a Breast Tumor Model

Jadia¹,

Kydd²,

Piel³

et al. 2018

Oncomedicine

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Curcumin (CUR), a natural compound, has multiple antineoplastic properties and specificity toward tumor cells, however its bioavailability and water solubility are poor. Liposomes increase the therapeutic index of CUR by protecting the drug from enzymatic degradation and can be made long circulating by surface modification with polyethylene glycol (PEG). Folate receptor α (FRα) is overexpressed in several types of cancer. Therefore, a folate-conjugated liposomal CUR nanoconstruct can enhance tumor targeted drug therapy. In this study, we synthesized, characterized and tested the cytotoxicity of CUR loaded liposomes (folate modified and non-folate modified) and CUR free drug in non-malignant breast epithelial cells and breast cancer cells, in addition to assessing the effects of CUR on cell cycle. The breast cancer cells not only had increased uptake of liposomes compared to non-malignant cells, but also more showed greater cytotoxicity resulted from treatments with free CUR and liposomal CUR (folate surface-modified and non-folate liposome types). The imaging and killing results, indicated that the liposomal CUR formulations do not alter the therapeutic efficacy and selectivity of CUR to provide anticancer benefits. Moreover, the differences in cellular uptake between the two liposomal nanoconstructs were studied using flow cytometry which showed targeting of folate surface-modified liposomes in cancer cells based on the findings presented.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Liposomes Aid Curcumin's Combat with Cancer in a Breast Tumor Model

Jadia¹,

Kydd²,

Piel³

et al. 2018

Oncomedicine

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“…These approaches, in particular, allow drug delivery directly to tumor sites without damaging nearby healthy tissues (Ahmad et al, 2018). In in vitro studies, enhanced anti-tumor activity was obtained, compared to respective unmodified substances, for nanoengineered phytobioactive compounds exerting antioxidant and anti-inflammatory activities such as resveratrol (Rodenak-Kladniew et al, 2017;Wang et al, 2017), curcumin (Meena et al, 2017;Dhivya et al, 2018;Montalban et al, 2018;Wang W. et al, 2018;Ni et al, 2019;Somu and Paul, 2019;van der Vlies et al, 2019), EGCG (Chavva et al, 2019), berberine (Wang et al, 2014a;Zheng et al, 2018), aloe-emodin (Wang et al, 2012;Chen et al, 2014), and oridonin (Wang et al, 2014b). In mouse models of the induced cancer, substantial inhibition of tumor proliferation and angiogenesis and also enhanced levels of apoptosis of cancerous cells have been found in animals administered, either orally or intravenously, with nanoparticles co-loaded with curcumin, along, or in combination with particular anti-cancer drugs (Wang et al, 2015b(Wang et al, , 2016Yang et al, 2015;Yan et al, 2016;Cui et al, 2017;Kumari et al, 2017;, in comparison to those for free substances.…”

Section: Nano-phytoantioxidants In Therapy Of Aging Disorders: Preclimentioning

confidence: 99%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

144

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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“…HeLa cells were obtained from National Centre for Cell Science (NCCS), Pune. OD treated@570 nm/OD control@570 nm) × 100% [16].…”

Section: Cell Line and Culture Conditionsmentioning

confidence: 99%

“…Surplus dye was cleansed-off using 1X PBS. Coverslip was fixed on a glass slide and was observed under a fluorescence microscope (Nikon ECLIPSE TiE, Tokyo, Japan) [16].…”

Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Identification, Quantification and <i>In-Vitro</i> Genotoxicity of Major Polyaromatic Hydrocarbons Produced by Sugarcane Fly Ash Emitted from Sugarmill

Verma¹,

Meena²,

Maurya³

et al. 2019

JEP

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Sugarcane burning during harvest and non-harvest season emits various pollutants like volatile organic compounds (VOCs), alkanes, and PAHs (Polyaromatic hydrocarbons) in the surrounding environment. Among these pollutants, PAHs are of uttermost concern due to their high level of toxicity. Burning of sugarcane bagase in sugar mill results in the production of fly ash. Fly ash is produced as a result of sugarcane bagasse burning in sugar mills. In present study, fly ash that comes out from the sugar mill chimney was collected from Western Uttar Pradesh, India and used for further analysis. High temperature and incomplete combustion inside chimney lead to the formation of PAHs. Extraction of PAHs present in fly ash samples was done by ultrasonication method and was identified with GC-FID (gas chromatography-flame ionization detector). Results exhibit the presence of eight PAHs in fly ash samples where the Benzo(a)pyrene and Naphthalene were found to be in high concentration. Furthermore, we have evaluated toxic effects of fly ash and Polyaromatic hydrocarbons (Standard of BaP & Nap) through different methods i.e. MTT, ROS and comet assay. Significant reduction (p < 0.001) in cell viability was noted in cells treated with fly ash as compared to control. Fly ash samples were also found to induce significant oxidative stress in HeLa cells, which ultimately causes DNA damage. Therefore, it may be concluded that the fly ash samples are toxic to the environment due to the presence of PAHs. Hence, the present study plays an important role in determining the harmful effects of PAHs and their source of occurrence.

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PLGA-CTAB curcumin nanoparticles: Fabrication, characterization and molecular basis of anticancer activity in triple negative breast cancer cell lines (MDA-MB-231 cells)

Cited by 42 publications

References 40 publications

Liposomes Aid Curcumin's Combat with Cancer in a Breast Tumor Model

Liposomes Aid Curcumin's Combat with Cancer in a Breast Tumor Model

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Identification, Quantification and <i>In-Vitro</i> Genotoxicity of Major Polyaromatic Hydrocarbons Produced by Sugarcane Fly Ash Emitted from Sugarmill

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PLGA-CTAB curcumin nanoparticles: Fabrication, characterization and molecular basis of anticancer activity in triple negative breast cancer cell lines (MDA-MB-231 cells)

Cited by 42 publications

References 40 publications

Liposomes Aid Curcumin's Combat with Cancer in a Breast Tumor Model

Liposomes Aid Curcumin's Combat with Cancer in a Breast Tumor Model

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Identification, Quantification and &lt;i&gt;In-Vitro&lt;/i&gt; Genotoxicity of Major Polyaromatic Hydrocarbons Produced by Sugarcane Fly Ash Emitted from Sugarmill

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Identification, Quantification and <i>In-Vitro</i> Genotoxicity of Major Polyaromatic Hydrocarbons Produced by Sugarcane Fly Ash Emitted from Sugarmill