PLGA based film forming systems for superficial fungal infections treatment

Snejdrova, Eva; Martiska, Juraj; Loskot, Jan; Paraskevopoulos, Georgios; Kováčik, Andrej; Regdon, Géza; Budai-Szűcs, Mária; Palát, Karel; Konečná, Klára

doi:10.1016/j.ejps.2021.105855

Cited by 10 publications

(9 citation statements)

References 66 publications

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“…The RSD values for precision and accuracy measured for terbinafine are under 1% as required by ICH Q2. 18 The values for all impurities were in a range of 0.32–5.00%.…”

Section: Resultsmentioning

confidence: 94%

Analysis of terbinafine in PLGA-based drug delivery systems by a fast and sensitive UHPLC-DAD method

et al. 2023

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“…The RSD values for precision and accuracy measured for terbinafine are under 1% as required by ICH Q2. 18 The values for all impurities were in a range of 0.32–5.00%.…”

Section: Resultsmentioning

confidence: 94%

Analysis of terbinafine in PLGA-based drug delivery systems by a fast and sensitive UHPLC-DAD method

et al. 2023

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“…There was also a small shift in the glass transition of the solid dispersion at 24.3 °C due to the incorporation of the drugs. Such a behavior occurred, because the drugs were molecularly dispersed in the PLGA carrier and acted as plasticizers [ 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

Allogeneic Bone Impregnated with Biodegradable Depot Delivery Systems for the Local Treatment of Joint Replacement Infections: An In Vitro Study

et al. 2022

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Although progress is evident in the effective treatment of joint replacement-related infections, it still remains a serious issue in orthopedics. As an example, the local application of antibiotics-impregnated bone grafts supplies the high drug levels without systemic side effects. However, antibiotics in the powder or solution form could be a risk for local toxicity and do not allow sustained drug release. The present study evaluated the use of an antibiotic gel, a water-in-oil emulsion, and a PLGA microparticulate solid dispersion as depot delivery systems impregnating bone grafts for the treatment of joint replacement-related infections. The results of rheological and bioadhesive tests revealed the suitability of these formulations for the impregnation of bone grafts. Moreover, no negative effect on proliferation and viability of bone marrow mesenchymal stem cells was detected. An ex vivo dissolution test of vancomycin hydrochloride and gentamicin sulphate from the impregnated bone grafts showed a reduced burst and prolonged drug release. The PLGA-based formulation proved to be particularly promising, as one-day burst release drugs was only 15% followed with sustained antibiotics release with zero-order kinetics. The results of this study will be the basis for the development of a new product in the Tissue Section of the University Hospital for the treatment of bone defects and infections of joint replacements.

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“…They also prevented biofilm formation and caused biofilm disruption [53]. A formulation based on poly(lactic-co-glycolic acid) (PLGA) for the delivery of terbinafine hydrochloride in the treatment of fungal infections also showed controlled delivery with prolonged release of up to 25 days [54]. This case demonstrates the possibility of a single-use therapy, where the film acts as a drug reservoir.…”

Section: In Situ Formation Of Film and Fiber-based Wound Dressingsmentioning

confidence: 86%

“…In situ formation of fibers and films obtained by solvent evaporation is yet another approach to spray wound dressings. The technique consists of solubilizing the polymer, either synthetic [51][52][53][54][55] or natural [56,57], in a suitable solvent and then spraying this solution. When the solvent evaporates, the polymer forms a protective film or, if the solution blow spinning (SBS) technique is used, a fibrillar mesh.…”

Section: In Situ Formation Of Film and Fiber-based Wound Dressingsmentioning

confidence: 99%

Sprayable Bioactive Dressings for Skin Wounds: Recent Developments and Future Prospects

Nozaki

Lima

Moraes

2022

Biomedical Materials & Devices

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The skin, as the body's main protection barrier from the environment, has an intrinsic self-repairable nature. However, proper wound healing only occurs under appropriate conditions. Skin wounds represent an economic burden on healthcare systems worldwide. Recent research has focused on developing new therapies, especially for chronic wounds. Among them, sprayapplied therapies have emerged as a promising strategy for allowing deeper penetration of the products, better conformability, easiness of application, lower discomfort for the patient, and lower risk of contamination during application. Specifically, sprayable wound dressings have been getting attention for enabling the treatment of severe cases or hard-to-heal wounds by incorporating different bioactive agents. Organic and inorganic compounds, natural extracts, signaling compounds, and live human cells have been investigated. In this context, this review summarizes the main findings of recently developed spray-applied bioactive wound dressings.

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PLGA based film forming systems for superficial fungal infections treatment

Cited by 10 publications

References 66 publications

Analysis of terbinafine in PLGA-based drug delivery systems by a fast and sensitive UHPLC-DAD method

Analysis of terbinafine in PLGA-based drug delivery systems by a fast and sensitive UHPLC-DAD method

Allogeneic Bone Impregnated with Biodegradable Depot Delivery Systems for the Local Treatment of Joint Replacement Infections: An In Vitro Study

Sprayable Bioactive Dressings for Skin Wounds: Recent Developments and Future Prospects

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