PLGA/alginate composite microspheres for hydrophilic protein delivery

Zhai, Peng; Chen, Daniel; Schreyer, David J.

doi:10.1016/j.msec.2015.06.015

Cited by 69 publications

(42 citation statements)

References 33 publications

(41 reference statements)

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“…In addition, SEP method is simple and more effective if compared to the others (i.e., rapid prototyping, melt extrusion, solvent evaporation, etc. ), utilized for biomedical applications and especially for scaffold fabrication [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Based on previous published works [14,15], in order an artificial ECM substrate to be functional, it must have the appropriate porosity and fiber diameter to facilitate adhesion, proliferation, and differentiation of cells. Simultaneously, it must have adequate stiffness and strength to withstand forces during bone redevelopment.…”

Section: Introductionmentioning

confidence: 99%

“…The obtained SEM images have been utilized to determine the mean fiber diameter, the porosity and the fiber distribution of each scaffold type. These characteristics significantly affect the mechanical performance and afterwards the cell activity during incubation and proliferation processes [14,15]. Furthermore, the hydrophilicity level of the fibrous scaffolds (both pristine and nano-filler containing) was determined by measuring the static water contact angle values.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and Characterization of Polyetherimide Electrospun Scaffolds Modified with Graphene Nano-Platelets and Hydroxyapatite Nano-Particles

Kostopoulos

Κοτρώτσος

Fouriki

et al. 2020

IJMS

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Solution electrospinning process (SEP) is a versatile technique for generating non-woven fibrous materials intended to a wide range of applications. One of them is the production of fibrous and porous scaffolds aiming to mimic bone tissue, as artificial extracellular matrices (ECM). In the present work, pure and nano-modified electrospun polyetherimide (PEI) scaffolds have been successfully fabricated. The nano-modified ones include (a) graphene nano-platelets (GNPs), (b) hydroxyapatite (HAP), and (c) mixture of both. After fabrication, the morphological characteristics of these scaffolds were revealed by using scanning electron (SEM) and transmission electron (TEM) microscopies, while porosity and mean fiber diameter were also calculated. In parallel, contact angle experiments were conducted so that the hydrophilicity level of these materials to be determined. Finally, the mechanical performance of the fabricated scaffolds was investigated by conducting uniaxial tensile tests. Ιn future work, the fabricated scaffolds will be further utilized for investigation as potential candidate materials for cell culture with perspective in orthopedic applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fabrication and Characterization of Polyetherimide Electrospun Scaffolds Modified with Graphene Nano-Platelets and Hydroxyapatite Nano-Particles

Kostopoulos

Κοτρώτσος

Fouriki

et al. 2020

IJMS

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“…11,12 The oil phase consisted of 50, 100, and 150 mg of ET, 150 mg of PLGA, and 23.2 mg, 46.4 mg, 58.0 mg of HNA in 1 mL of DCM. ET was purchased from H. Lundbeck (Copenhagen, Denmark).…”

Section: Methodsmentioning

confidence: 99%

PLGA Microsphere Addition to 1‐Hydroxy‐2‐napthoic Acid Enhances the Sustained Release of Escitalopram

Kang

Kim

Kwon

et al. 2019

Bulletin Korean Chem Soc

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Escitalopram (ET), a selective serotonin reuptake inhibitor, has been utilized for the treatment of depression and anxiety. However, ET has serious side effects such as nausea, leading to an increased therapeutic dose, needing multiple administrations. Therefore, to overcome these issues, we developed ET encapsulated poly (d,l-lactic-co-glycolic acid) (PLGA) microspheres (PLGA-MS) as a sustained release carrier to maintain therapeutic efficacy. The mean particle size of the PLGA-MSs was measured by microscopy. Loading efficiency was measured by high performance liquid chromatography (HPLC). Morphologies were determined by microscopy and scanning electron microscopy (SEM). Differential scanning calorimetry (DSC) was used for thermal analysis and glass transition temperature determination. Mean particle size of the ET-loaded PLGA-MSs was 129 AE 14 μm, loading efficiency was 36.8 AE 9.1%, and encapsulation efficiency was up to 70.6 AE 6.8%. Loading efficiency and encapsulation efficiency were increased by the addition of 1-hydroxy-2-naphthoic acid (HNA). ET was released from PLGA-MS for 4 weeks, which was longer than ET release from PLGA-MS without the addition of HNA. Taken together, we demonstrate the optimum condition for sustained release of ET from PLGA-MS with the addition of HNA, and that this approach may be useful for depression therapy.

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“…These inhibitory proteins, i.e., Nogo-A, bind and activate the Nogo-66 receptor that is known to facilitate axonal growth inhibition, leading to profound inhibition of growth cone motilities. To overcome this inhibitory environment, alginate microspheres have been used as drug delivery systems to deliver Nogo receptor-blocking peptides to antagonize the inhibitory effect of Nogo-A on axon growth [81,82]. These microspheres, used either alone or incorporated into tissue engineering scaffolds, can be used to overcome-at least partially-the inhibitory environments in the CNS to improve nerve regeneration.…”

Section: D Biomaterials For Drug Delivery Systemsmentioning

confidence: 99%

Advancements in Canadian Biomaterials Research in Neurotraumatic Diagnosis and Therapies

Chen

Auriat

et al. 2019

Processes

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Development of biomaterials for the diagnosis and treatment of neurotraumatic ailments has been significantly advanced with our deepened knowledge of the pathophysiology of neurotrauma. Canadian research in the fields of biomaterial-based contrast agents, non-invasive axonal tracing, non-invasive scaffold imaging, scaffold patterning, 3D printed scaffolds, and drug delivery are conquering barriers to patient diagnosis and treatment for traumatic injuries to the nervous system. This review highlights some of the highly interdisciplinary Canadian research in biomaterials with a focus on neurotrauma applications.

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PLGA/alginate composite microspheres for hydrophilic protein delivery

Cited by 69 publications

References 33 publications

Fabrication and Characterization of Polyetherimide Electrospun Scaffolds Modified with Graphene Nano-Platelets and Hydroxyapatite Nano-Particles

Fabrication and Characterization of Polyetherimide Electrospun Scaffolds Modified with Graphene Nano-Platelets and Hydroxyapatite Nano-Particles

PLGA Microsphere Addition to 1‐Hydroxy‐2‐napthoic Acid Enhances the Sustained Release of Escitalopram

Advancements in Canadian Biomaterials Research in Neurotraumatic Diagnosis and Therapies

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