Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography

Hormel, Tristan T.; Jia, Yali; Jian, Yifan; Hwang, Thomas S.; Bailey, Steven T.; Pennesi, Mark E.; Wilson, David J.; Morrison, John C.; Huang, David

doi:10.1016/j.preteyeres.2020.100878

Cited by 87 publications

(73 citation statements)

References 236 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[ 31 ] OCTA is a promising and emerging technique for imaging the retinal vasculature without dye injection, and it appears as a comprehensive management of retinopathy related to vascular aging. [ 32 ] OCTA visualizes the ocular blood flow in the retinal network and is essential for locating and measuring the sizes of various pathological alternations. Studies have demonstrated that OCTA shows a favorable effect on detecting angiographic features, even before the disease onset, which may be a useful method for vascular aging-related diseases.…”

Section: Structural Assessment Of Vascular Agingmentioning

confidence: 99%

Progress of clinical evaluation for vascular aging in humans

Qiu

Liu

Tao

2021

Journal of Translational Internal Medicine

View full text Add to dashboard Cite

Human society is experiencing a serious aging process. Age-related arteriosclerotic cardiovascular diseases (ASCVD) are the most common cause of deaths around the world and bring a huge burden on the whole society. Vascular aging-related pathological alterations of the vasculature play an important role in the pathogenesis of ASCVD and morbidity and mortality of older adults. In this review, we describe the progress of clinical evaluation of vascular aging in humans, including functional evaluation, structural assessment, and cellular molecular markers. The significance of detection for vascular aging is highlighted, and we call for close attention to the evaluation for a better quality of life in the elderly population.

show abstract

Section: Structural Assessment Of Vascular Agingmentioning

confidence: 99%

Progress of clinical evaluation for vascular aging in humans

Qiu

Liu

Tao

2021

Journal of Translational Internal Medicine

View full text Add to dashboard Cite

show abstract

“…However, this vascular complex has been investigated in glaucomatous eyes with controversial findings, and it seems to be unaffected by glaucoma. 38 , 39 Another limitation is the exclusion of the peripapillary portion of the CC and the deeper layers of the choroid from the investigation. Extending the OCTA segmentation to the outer choroid could have disclosed further interesting insights.…”

Section: Discussionmentioning

confidence: 99%

The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study

Milani

Urbini

Bulone

et al. 2021

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE.To assess quantitatively the choriocapillaris (CC) perfusion area in the macular area of healthy eyes, eyes with primary open-angle glaucoma, and eyes with ocular hypertension using optical coherence tomography angiography (OCTA). METHODS.A consecutive series of healthy individuals and patients with glaucoma and ocular hypertension were recruited prospectively in this single-center, cross-sectional study based in Milan, Italy. OCTA was performed in the morning and evening, along with a complete ophthalmologic examination. Macular superficial capillary plexus vessel density (SCP-VD) and the thicknesses of the retina and ganglion cell complex (GCC), as well as their fluctuations, were investigated. RESULTS.Thirty-nine eyes from 24 individuals with glaucoma (mean age = 58.79 ± 6 years), 43 eyes from 27 individuals with ocular hypertension (59.19 ± 6 years), and 54 eyes from 35 controls (58.27 ± 6 years) were enrolled. The mean CC perfusion area values were not significantly different among the three groups in the morning or evening (P ≥ 0.47). In contrast, SCP-VD, retinal thickness, and GCC thickness were statistically different among the groups (P ≤ 0.016), except for the foveal SCP-VD (P ≥ 0.19) and the evening foveal thickness (P = 0.57). Diurnal changes in the CC perfusion area, SCP-VD, retinal thickness, and GCC thickness were not statistically significant (P ≥ 0.16). Systemic hypertension, sex, age, axial length, and diurnal changes in intraocular pressure were not significantly associated with morning or evening measurements, or with diurnal fluctuations (P ≥ 0.07). CONCLUSIONS.The macular CC flow perfusion area appears unaffected in eyes with primary open-angle glaucoma. No significant diurnal changes were observed in any of the parameters investigated.

show abstract

“…It is associated with intraretinal cystoid edema with or without subretinal RPE fluid [81]. The pathophysiology of type 3 MNV remains unclear, but in recent years, OCTA has increasingly played a greater role in the diagnosis and treatment monitoring of this retinal disease [83].…”

Section: Octa In Type 3 Mnv Secondary To Amdmentioning

confidence: 99%

Optical Coherence Tomography Angiography in Intermediate and Late Age-Related Macular Degeneration: Review of Current Technical Aspects and Applications

et al. 2020

View full text Add to dashboard Cite

Optical coherence tomography angiography (OCTA) is a non-invasive diagnostic instrument that has become indispensable for the management of age-related macular degeneration (AMD). OCTA allows quickly visualizing retinal and choroidal microvasculature, and in the last years, its use has increased in clinical practice as well as for research into the pathophysiology of AMD. This review provides a discussion of new technology and application of OCTA in intermediate and late AMD.

show abstract

Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography

Cited by 87 publications

References 236 publications

Progress of clinical evaluation for vascular aging in humans

Progress of clinical evaluation for vascular aging in humans

The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study

Optical Coherence Tomography Angiography in Intermediate and Late Age-Related Macular Degeneration: Review of Current Technical Aspects and Applications

Contact Info

Product

Resources

About