Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature

Amer, Samir M.; Ukudeyeva, Aijan; Pine, Harold S.; Campbell, Gerald A.; Clement, Cecilia

doi:10.1155/2018/9814591

Cited by 5 publications

(8 citation statements)

References 24 publications

(25 reference statements)

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“…However, if gone untreated, the tumor can continue to grow to the point where it becomes debilitating or, rarely, life-threatening. 2 Surgical intervention has been incorporated in most treatment plans 3,4 and has previously shown to be effective at restoring arm function when the tumor affects the brachial plexus. 5…”

Section: Introductionmentioning

confidence: 99%

Use of a three-dimensional printed anatomical model for tumor management in a pediatric patient

Salazar

Huff

Cramer

et al. 2020

SAGE Open Medical Case Reports

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The purpose of this study was to investigate the usage of an anatomical model to improve surgical planning of a complex schwannoma resection. As advancements in additive manufacturing continue to prosper, new applications of this valuable technology are being implemented in the medical field. One of the most recent applications has been in the development of patient-specific anatomical models for unique clinical education as well as for preoperative planning. In this case, a multidisciplinary team with expertise in research, three-dimensional printing, and medicine was formed to develop a three-dimensional printed model that could be used to help plan the reduction of a tumor from the cervical spine of a pediatric patient. Image segmentation and stereolithography creation were accomplished using Mimics and 3-matic, respectively. Models were developed on two different printer types to view different aspects of the region of interest. Reports from the operating surgeon indicated that the model was instrumental in the planning procedures of the operation and reducing operation time.

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Section: Introductionmentioning

confidence: 99%

Use of a three-dimensional printed anatomical model for tumor management in a pediatric patient

Salazar

Huff

Cramer

et al. 2020

SAGE Open Medical Case Reports

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“…Two of these cases, one pediatric case from United States and other adult patient from Japan, were associated with neurofibromatosis type 2 (NF2). 14,15 They both were histologically confirmed and treated with surgical excision. Earlier to these reported cases, only three cases of lingual schwannomas in patients with NF2 have been reported, all of which were single, well-circumscribed, nodular lesion on the dorsal surface of the tongue.…”

Section: Discussionmentioning

confidence: 93%

A rare clinical case: schwannoma of tongue

Singh

Radia

Sheikh

et al. 2019

Int J Otorhinolaryngol Head Neck Surg

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Schwannoma are slow growing tumours, which can arise from any peripheral nerve. 10% of schwannomas that occur in the head and neck region mostly originate from the vagus or sympathetic nervous system. Extracranial schwannomas in the head and neck region are rare neoplasm. Intraoral schwannoma are only 1% of the all head and neck tumours. Diagnosis is established by imaging studies such as magnetic resonance imaging or computed tomography, while FNAC is used to rule out other conditions. We report a rare case of lingual schwannomas generally present as a painless lump schwannoma of the tongue in a 27-year-old male complaining of asymptomatic swelling over a posterolateral surface of the tongue, treated by complete surgical excision. The diagnosis was established on the basis of clinical, histopathological, and immunohistochemical examination. We report a rare case of schwannoma over the posterolateral surface of tongue. Prognosis is good for the patient when this condition is correctly diagnosed as the condition rarely recurs after complete resection.

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“…While the description of discrete PNS in NF2 dates back from the first description of the disease, 19 the description of multinodular tumors is rather recent in major nerves 8 and soft tissue locations such as the skin, 25 the stomach, 26 the tongue 27 and the larynx. 28 The exact incidence of multinodular cases among PNS remains unknown in the absence of a systematic screening.…”

Section: Discussionmentioning

confidence: 99%

Surgical Management of Peripheral Nerve Pathology in Patients With Neurofibromatosis Type 2

et al. 2022

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BACKGROUND:Neurofibromatosis type 2 (NF2) is rare genetic disorder mainly characterized by the development of central nervous system lesions, but peripheral nerve pathology may also cause high morbidity including pain, motor, and sensory loss.OBJECTIVE:To describe the tumor burden of patients with peripheral nerve pathology in NF2 including peripheral neuropathies and schwannomas and the results of surgery in the latter group.METHODS:We conducted a retrospective chart review of all patients with NF2 followed up at our NF2 Reference Center to include all patients suffering from peripheral nerve pathology. Tumor detection relied on focal MRIs based on symptoms.RESULTS:Thirty-four patients harboring 105 peripheral nerve schwannomas and 1 perineurioma were included. Schwannomas were mainly located in major nerves (n = 74, 71%) compared with subcutaneous (n = 23, 22%) and intramuscular (n = 8, 7%) cases. Most schwannomas (81/90-90%) were classical discrete tumors while multinodular cases represented only 9 cases (10%). During follow-up, 63 (60%) tumors were operated in 24 patients, including 39 schwannomas of major nerves. A complete resection was achieved in most of the cases (52/63, 83%) with a complete relief of preoperative pain in most patients (57/60, 95%). Persistent motor deficits (5/39, 13%) were mostly encountered in patients operated from multinodular schwannomas (4/5, 80%). Six patients had an associated peripheral neuropathy with 5 cases of pseudo-Charcot-Marie-Tooth–associated amyotrophy.CONCLUSION:Surgery remains a safe and effective method of treating peripheral nerve schwannoma-associated pain in NF2, with the exception of rare multinodular tumors. Special attention should be drawn to patients harboring severely debilitating neuropathies and perineuriomas.

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Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature

Cited by 5 publications

References 24 publications

Use of a three-dimensional printed anatomical model for tumor management in a pediatric patient

Use of a three-dimensional printed anatomical model for tumor management in a pediatric patient

A rare clinical case: schwannoma of tongue

Surgical Management of Peripheral Nerve Pathology in Patients With Neurofibromatosis Type 2

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