Plexiform Angiomyxoid Myofibroblastic Tumor (PAMT) of Stomach with Synchronous Bilateral Cystic Ovarian Neoplasms, a Rare Case Presentation

Dixit, Jagannath; Sharief, Shiraz Ahamed; Goyal, Manish; Khan, Sameeha; Kauser, Lubna

doi:10.1007/s13193-015-0454-4

Cited by 11 publications

(4 citation statements)

References 8 publications

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“…To better understand the clinicopathologic features of PF, we performed a brief review of the literature (Table 1). 1–51 Taking the present study into account, the tumor is located mainly in the gastric antrum and pylorus (76%), but other rare locations, such as the gastric fundus, gastric body, duodenum, jejunum, cecum, gallbladder, posterior mediastinum, and esophagus, have also been reported. 2 , 17 , 29 , 47 The overall median and average ages of patients with PF at diagnosis were 46 years and 43.3 years, respectively (range, 5 to 81 years).…”

Section: Discussionmentioning

confidence: 69%

Plexiform fibromyxoma: a clinicopathological and immunohistochemical analysis of two cases with a literature review

Wang

et al. 2021

J Int Med Res

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Objective This article aimed to study the clinicopathological features, immunophenotypes, and differential diagnoses of plexiform fibromyxoma (PF). Methods We searched clinical and pathology databases of our hospital for patients with histologically confirmed PF from 2007 to 2020 and reviewed the relevant English and Chinese language literature. Results Two cases of PF were identified, a 67-year-old woman and a 23-year-old man. Both patients presented with melena and anemia and underwent partial gastrectomy. Histologically, the tumors exhibited a plexiform growth pattern in the gastric submucosa and the presence of bland-looking spindle cells in the fibromyxoid stroma with the formation of small blood vessels. Immunohistochemically, the two cases were strongly positive for vimentin, smooth muscle actin, and muscle-specific actin and negative for CD117, discovered on gastrointestinal stromal tumors protein 1, CD34, CD10, S100, desmin, H-caldesmon, estrogen receptor, progesterone receptor, β-catenin, and cytokeratin. Conclusions PF is a rare mesenchymal tumor of the stomach that can be distinguished from other gastrointestinal mesenchymal tumors based on its distinctive morphology and immunophenotype.

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Section: Discussionmentioning

confidence: 69%

Plexiform fibromyxoma: a clinicopathological and immunohistochemical analysis of two cases with a literature review

Wang

et al. 2021

J Int Med Res

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“…The term PF was used due to its cellular architecture and fibromyxoid nature, allowing nonprofessionals to recognize that it is a benign disease when encountering this spectrum of lesions. Despite that the WHO classification established the nomenclature, many authors still believe that the term PAMT better describes the histogenesis and histology of such tumors[ 16 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Plexiform angiomyxoid myofibroblastic tumor treated by endoscopic submucosal dissection: A case report and review of the literature

Chen

Luo

et al. 2021

WJG

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BACKGROUND Plexiform angiomyxoid myofibroblastic tumor (PAMT) is a rare mesenchymal tumor characterized by multiple nodular plexiform growth patterns and an immunophenotype with myofibroblasts. The pathological characteristics, immunohistochemistry, diagnostic criteria, differential diagnosis, and gene-level changes of PAMT have been reported in many studies. At present, the main treatment for PAMT in the reported cases is surgery; only eight cases were treated via endoscopy (excluding 1 thoracoscopic resection), and the lesions were all smaller than 5 cm. There are no reports on the prognosis and follow-up of young patients with lesion sizes reaching 5 cm who undergo endoscopic submucosal dissection (ESD). Herein, we present the first case of a young patient with a lesion size reaching 5 cm who was diagnosed with PAMT via endoscopic submucosal dissection. CASE SUMMARY A 15-year-old young man with upper abdominal pain for 2 years presented to the Gastroenterology Department of our hospital. Painless gastroscopy showed a semicircular bulge approximately 5 cm in size in the lesser curvature near the cardia of the fundus; the surface was eroded, and shallow ulcers had formed. The pathological manifestations of the biopsy were spindle cell proliferative lesions with interstitial mucinous changes, and the surface mucosa showed chronic inflammatory changes with active lesions; immunohistochemistry showed smooth muscle actin (SMA) (+), CD117 (-), CD34 (-), DOG-1 (-), S-100 (-), and Ki67 (LI: < 1%). We performed ESD on the patient. The lesion that we removed was 5 cm × 4 cm × 2 cm in size. Pathologically, the resected tissue displayed typical manifestations, such as fat spindle-shaped fibroblasts and myofibroblast-like cells showing irregular nodular hyperplasia. Immunohistochemistry staining of the tumor cells revealed the following: CD34 (partially +), SMA (weakly +), CD117 (-), DOG-1 (-), S-100 (-), SDHB (+), PCK (-), and Ki67 (labelling index: 2%). There was no recurrence or metastasis during the 3-mo follow-up after the operation, and the treatment effect was good. We also performed a review of the literature on the clinical manifestations, pathological features, immunohistochemistry, and differential diagnosis of PAMT. CONCLUSION At present, the diagnostic criteria for PAMT are relatively clear, but the pathogenesis and genetic changes require further study. PAMT is benign in nature, and these patients are less likely to experience local or metastatic recurrence. The main treatment is still surgery if the lesion is in the stomach. Partial gastrectomy and distal gastrectomy are the most frequently performed surgical treatments for PAMT, followed by local resection, subtotal gastrectomy, and wedge resection. But for comprehensive evaluation of the disease, ESD can be considered a suitable method to avoid excessive treatment.

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“…Plexiform fibromyxomas are recently identified mesenchymal tumors of the GI tract, almost always found in the stomach [17–20] with few reports of its development in other tissues or organs. [21,22] To date, no case of duodenal origin and only 5 cases of duodenal bulb involvement were published.…”

Section: Discussionmentioning

confidence: 99%

Duodenal plexiform fibromyxoma as a cause of obscure upper gastrointestinal bleeding

et al. 2017

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Rationale:We are reporting the first-to our knowledge-case of duodenal Plexiform Fibromyxoma causing obscure upper gastrointestinal bleeding.Patient concerns:Plexiform fibromyxoma triggered recurrent upper gastrointestinal bleeding episodes in a 63-year-old man who remained undiagnosed, despite multiple hospitalizations, extensive diagnostic workups and surgical interventions (including gastrectomies), for almost 17 years.Diagnoses-Interventions:During hospitalization for the last bleeding episode, an upper gastrointestinal endoscopy revealed an intestinal hemorrhagic nodule. The lesion was deemed unresectable by endoscopic means. An abdominal computerized tomography disclosed no further lesions and surgery was decided. The lesion at operation was found near the edge of the duodenal stump and treated with pancreas-preserving duodenectomy (1st and 2nd portion).Outcomes:Postoperative recovery was mainly uneventful and a 20-month follow-up finds the patient in good health with no need for blood transfusions.Plexiform fibromyxomas stand for a rare and widely unknown mesenchymal entity. Despite the fact that they closely resemble other gastrointestinal tumors, they distinctly vary in clinical management as well as the histopathology. Clinical awareness and further research are compulsory to elucidate its clinical course and prognosis.

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Plexiform Angiomyxoid Myofibroblastic Tumor (PAMT) of Stomach with Synchronous Bilateral Cystic Ovarian Neoplasms, a Rare Case Presentation

Cited by 11 publications

References 8 publications

Plexiform fibromyxoma: a clinicopathological and immunohistochemical analysis of two cases with a literature review

Plexiform fibromyxoma: a clinicopathological and immunohistochemical analysis of two cases with a literature review

Plexiform angiomyxoid myofibroblastic tumor treated by endoscopic submucosal dissection: A case report and review of the literature

Duodenal plexiform fibromyxoma as a cause of obscure upper gastrointestinal bleeding

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