Plexiform Angiomyxoid Myofibroblastic Tumor of the Stomach: a Rare Case

Kim, Su Mi; An, Ji Yeong; Choi, Min-Gew; Lee, Jun Ho; Sohn, Tae Sung; Kim, Kyung-Mee; Kim, Sung; Bae, Jae Moon

doi:10.5230/jgc.2017.17.e22

Cited by 11 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The likelihood that PF could directly or indirectly provoke reflux symptoms is doubtful, and the reflux symptoms were more likely to be concurrent with PF because of the high GERD prevalence worldwide. Ten cases were diagnosed incidentally, even with ulcerative PF lesions [25, 33, 59]; the size of incidentally diagnosed tumor ranged from 0.8 to 4.5 cm, and 4 tumors were located at gastric body, 1 was located at gastric fundus, and 5 were located at gastric antrum or pylorus [1, 16, 25, 27, 33, 37, 56, 59, 61]. Two cases with hemorrhagic perforation were reported by Takahashi et al and Tan et al, with maximal tumor diameters of 4 and 3.5 cm, respectively [1, 21].…”

Section: Clinical Presentationmentioning

confidence: 99%

An Update on Clinicopathological and Molecular Features of Plexiform Fibromyxoma

Yen

Chen

2019

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

Plexiform fibromyxoma is a rare and newly described gastric mesenchymal tumor with only 121 reported cases in the literature. Our understanding of plexiform fibromyxoma requires updating since the first case has been reported by Takahashi et al. 12 years ago. The present review summarized reported cases in the literature, and both clinical and pathological aspects of plexiform fibromyxoma were comprehensively discussed. Plexiform fibromyxoma usually causes nonspecific or bleeding signs or symptoms, and therefore clinical recognition of the disease is challenging. Plexiform fibromyxoma is of benign nature without any metastasis or recurrence reported, and more conservative surgical treatment should be considered.

show abstract

Section: Clinical Presentationmentioning

confidence: 99%

An Update on Clinicopathological and Molecular Features of Plexiform Fibromyxoma

Yen

Chen

2019

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

show abstract

“…7Synovial sarcoma: it is a malignant mesenchymal tumor showing epithelioid differentiation to varying degrees, with characteristic chromosomal translocation t(X;18) (p11;q11) and the resulting SS18-SSX gene fusion. Mainly occurring in the limbs of young people, gastric synovial sarcoma is very rare, and 24 cases have been reported in the English literature [17] . A typical synovial sarcoma is composed of cancer-like epithelioid cells and brosarcoma-like spindle cells mixed in different proportions to form a biphasic structure.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Features and Immunophenotype of Primary Gastric Invasive Fibromatosis

Wang¹,

Zhang²,

Jiang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background To investigate the histopathological characteristics, immunophenotype and differential diagnosis of primary gastric invasive fibromatosis.Methods The clinical manifestations, histological morphology and immunophenotype of 4 cases of primary gastric invasive fibromatosis were observed and related literatures were reviewed.Results Among the 4 patients, 2 were males and 2 were females, aged 28 and 47 years, respectively. The lesions were located in the stomach in 2 cases, the gastric antrum in 1 case and cardia in 1 case. Under the microscope, the tumor was located in the submucosa, growing infiltratingly, and infiltrating into the gastric wall muscularis, serous membrane and extraserous fatty tissue. Tumor cells were rich in cytoplasm, with unclear cell boundaries, long rod-shaped nuclei, deep chromatin, no atypia, and rare mitotic figures. The tumor tissue was composed of proliferating spindle-shaped fibroblasts and collagen fibers, and the cell morphology was relatively uniform, arranged in parallel bundles or staggered weaves. Tumor tissue invaded and destroyed smooth muscle, blood vessels, nerve tissue and adipose tissue of the gastric wall. Immunophenotype: positive expression of vimentin, β-catenin, SMA positive expression; CKpan, EMA, S-100 protein, desmin, CD99, Bcl-2, ALK, CD34, CD117, DOG1, hormone receptors were all negative; The cell proliferation index ki-67 positive cells were 3–5%.Conclusion Primary invasive fibromatosis of the stomach is a relatively rare spindle cell tumor, which needs to be differentiated from tumors and pathological lesions such as inflammatory myofibroblastic tumor, plexiform mucinous fibroma, gastrointestinal stromal tumor, etc.

show abstract

“…However, as the number of reported cases has increased, this is no longer thought to be the case. So far, > 60 cases of PAMT or plexiform fibromyxoma have been reported worldwide[5]. The published literature suggests that plexiform fibromyxoma is mainly located in the gastric antrum and prepyloric area, but some reports indicate that the tumor originates from the gastric fundus[8], gastric body[9], the duodenum, and even the cecum[10] and posterior mediastinum may be involved[11].…”

Section: Discussionmentioning

confidence: 99%

“…It was classified as a gastrointestinal mesenchymal tumor in the 2010 World Health Organization Classification of Digestive System Neoplasms[3] and was termed plexiform fibromyxoma. Many scholars, however, still prefer using PAMT rather than plexiform fibromyxoma[4,5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plexiform fibromyxoma of the small bowel: A case report

Zhang

Xiang

et al. 2018

WJCC

View full text Add to dashboard Cite

BACKGROUNDPlexiform fibromyxoma is a rare, special type of mesenchymal tumor. The most common presenting symptoms are anemia, hematemesis, and hematochezia, without sex or age predilection. The reported cases have mainly occurred in the gastric antrum and pylorus region, with some cases in the duodenum.CASE SUMMARYWe report here a case of plexiform fibromyxoma in the upper segment of the jejunum, which was continuously followed up for 3 years after surgical removal. Plexiform fibromyxoma showed multinodular or plexiform growth. The cells in the tumor node were spindle-shaped but few in number and mitotic figures. Small blood vessels and mucous matrix were found among the tumor cells. Immunohistochemistry revealed that the plexiform fibromyxoma cells were positive for smooth muscle actin, focally positive for CD10, and negative for cytokeratin, CD117, DOG-1 (discovered on GIST-1) desmin, S-100, epithelial membrane antigen, and CD34. Ki-67 labeling index was < 5%. Plexiform fibromyxoma showed benign biological behavior. After 3 years of consecutive postoperative follow-up, no obvious signs of metastasis or recurrence were found by imaging examination.CONCLUSIONPlexiform fibromyxoma is a rare type of mesenchymal tumor. The diagnosis mainly depends on pathological examination, and it should be distinguished from other gastrointestinal mesenchymal tumors.

show abstract

Plexiform Angiomyxoid Myofibroblastic Tumor of the Stomach: a Rare Case

Cited by 11 publications

References 10 publications

An Update on Clinicopathological and Molecular Features of Plexiform Fibromyxoma

An Update on Clinicopathological and Molecular Features of Plexiform Fibromyxoma

Histopathological Features and Immunophenotype of Primary Gastric Invasive Fibromatosis

Plexiform fibromyxoma of the small bowel: A case report

Contact Info

Product

Resources

About